A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments

Kendrick, Keith M.; Daumann, Jörg; Wagner, Daniel R.; Koester, Philip; Tittgemeyer, Marc; Luo, Qiang; Becker, Benjamin

doi:10.1101/2020.10.29.361378

Cited by 1 publication

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References 50 publications

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“…However, we cannot be sure if the difference in memory outcomes is due to a possible recovery effect or that King et al [22] did not control for use of other stimulant-type drugs (e.g., amphetamine or MDMA). Especially the second aspect is important, since use of other stimulant-type drugs has also been shown to be related to impairments in verbal memory [48].…”

Section: Discussionmentioning

confidence: 99%

Verbal learning impairment in adolescents with methamphetamine use disorder: a cross-sectional study

et al. 2021

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Background Methamphetamine (MA) use has been shown to be associated with deficits in impulsivity, verbal learning, and working memory. Additionally, methamphetamine use disorder (MUD) is related to various brain changes, especially in adolescent users who might be more vulnerable to detrimental effects on brain development. However, little is known about the relationship between adolescent MA use and cognitive impairment. This cross-sectional study aims to explore how the presence of a MUD in adolescents is related to impairments of verbal memory, inhibition, and alertness. Methods N = 18 psychiatric outpatients with MUD were matched in terms of depressivity, age, and gender to n = 18 adolescents with other substance use disorders (SUDs), as well as n = 18 controls without SUDs. We compared these three groups on the Verbal Learning and Memory Task (VLMT), and the alertness and go/noGo subtests of the Test of Attentional Performance (TAP). Additionally, Spearman’s rank order correlation coefficients were calculated to investigate whether cognitive functioning was directly associated with frequency of past year MA use. Results The three groups differed significantly in their verbal learning performance (H (2) = 11.7, p = .003, ηp2 = .19), but not in short-term memory, inhibition, cued recall, or alertness. Post hoc tests revealed significant differences in verbal learning between the MA using group and the control group without a SUD (U = 56.5, p = .001, ηp2 = .31). Frequency of past year MA use correlated negatively with short-term memory (ρ = −.25, p < .01) and verbal learning (ρ = −.41, p < .01). No other cognitive variables correlated significantly with MA use frequency. Significant p-values were considered significant after Bonferroni correction. Conclusions Adolescent MUD outpatients with regular MA use show specific impairment in verbal learning performance, but not in other basal cognitive functions when compared to adolescents without a MUD. Verbal learning and short-term memory performance is negatively associated with the frequency of MA use. Future research should apply longitudinal designs to investigate long-term effects of methamphetamine and reversibility of these effects on cognitive functioning.

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Section: Discussionmentioning

confidence: 99%