A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer

Forrest, L M; McMillan, Donald C.; McArdle, C. S.; Angerson, Wilson J.; Dagg, Kenneth D; Scott, H R

doi:10.1038/sj.bjc.6602591

Cited by 133 publications

(139 citation statements)

References 14 publications

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“…This work is consistent with previous work in patients with inoperable nonsmall-cell lung cancer (Forrest et al, 2003(Forrest et al, , 2004(Forrest et al, , 2005 and improves on the prediction of survival using an elevated C-reactive protein alone (Albuquerque et al, 1995;Zhang and Adachi, 1999). If these results are confirmed in larger studies, the GPS may be useful in the assessment of advanced breast cancer patients at diagnosis and the stratification of patients entering randomised trials.…”

Section: Discussionsupporting

confidence: 90%

“…Recently, we have shown that, using established cutoffs, a combination of an elevated C-reactive protein and hypoalbuminaemia, the Glasgow Prognostic score (GPS) has prognostic value, independent of stage and performance status, in patients with inoperable non-small-cell lung cancer (Forrest et al, 2003(Forrest et al, , 2004(Forrest et al, , 2005. However, there is no information on the prognostic value of this combination in patients with metastatic breast cancer.…”

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confidence: 99%

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Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer

Murri¹,

Bartlett²,

et al. 2006

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Prediction of outcome in patients with metastatic breast cancer remains problematical. The present study evaluated the value of an inflammation-based score (Glasgow Prognostic Score, GPS) in patients with metastatic breast cancer. The GPS was constructed as follows: patients with both an elevated C-reactive protein (410 mg l À1 ) and hypoalbuminaemia (o35 g l À1 ) were allocated a score of 2. Patients in whom only one or none of these biochemical abnormalities was present were allocated a score of 1 or 0, respectively. In total, 96 patients were studied. During follow-up 51 patients died of their cancer. On multivariate analysis of the GPS and treatment received, only the GPS (HR 2.26, 95% CI 1.45 -3.52, Po0.001) remained significantly associated with cancer-specific survival. The presence of a systemic inflammatory response (the GPS) appears to be a useful indicator of poor outcome independent of treatment in patients with metastatic breast cancer.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer

Murri¹,

Bartlett²,

et al. 2006

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“…Serum albumin was previously demonstrated to predict poor long-term outcome following cancer resection independently of CRP and has subsequently been combined with CRP to produce prognostic inflammatory scores validated in varied maligancies. 23,31,32 The current study confirmed that serum albumin and cellular markers of the SIR may also exhibit independent prognostic significance in malignancy and, along with the CRS, the other independent predictor of outcome, could be combined to produce a novel score with high prognostic value. Of note, these data are all routinely available preoperatively.…”

Section: Discussionsupporting

confidence: 65%

“…2,13,20,23,26,31,39 For simplicity, high numbers of cells indicates cell numbers higher than the cut-off levels and low numbers of cells indicates cell numbers lower than the cut-off levels. Carstairs deprivation scores were analysed following allocation into established UK-based score quintiles.…”

Section: Statisticsmentioning

confidence: 99%

“…Recently, however, it has been postulated that hypoalbuminaemia develops secondary to the SIR. 29,30 Hypoalbuminaemia predicts poor outcome in several cancer types 14,31 and has been combined with CRP to form inflammatory prognostic scores in a number of maligancies. 23,31,32 The prognostic value of serum albumin and its relationship to other systemic inflammatory biomarkers has yet to be examined in the context of resectable CLM.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Neal¹,

Mann²,

Sutton³

et al. 2009

European Journal of Cancer

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Background: There is increasing evidence that the presence of a preoperative systemic inflammatory response (SIR) independently predicts poor long-term outcome in patients with colorectal cancer (CRC).Socioeconomic deprivation was reported to correlate with the presence of the SIR and to itself independently predict poor outcome following primary CRC resection. The aim of this study was to determine the prognostic value of preoperative systemic inflammatory biomarkers and socioeconomic deprivation in patients undergoing resection of colorectal liver metastases (CLM) and to examine correlations between these variables in this context. Results: On multivariable analysis, poor CRS (3-5), high neutrophil count (>6.0 x10 9 /L) and low serum albumin (<40 g/dL) were the only independent predictors of shortened overall survival following metastasectomy, with neutrophil count representing the greatest relative risk of death. These factors were also the only independent predictors of shortened disease-free survival 3 following hepatectomy. Socioeconomic deprivation was associated with neither systemic inflammation nor long-term outcome in this context. Patients and methods: Conclusions:The presence of a preoperative systemic inflammatory response, but not socioeconomic deprivation, independently predicts shortened survival following resection of CLM.4

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Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

Imaoka

Ohira

Sato

et al. 2021

Annals of Gastroent Surgery

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Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Results Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). Conclusions Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score.

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A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer

Cited by 133 publications

References 14 publications

Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer

Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

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