A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns

McKinstry, Robert C.; Miller, Jeffrey H; Snyder, Abraham Z.; Mathur, Amit M.; Schefft, G. L.; Almli, C. Robert; Shimony, Joshua S.; Shiran, Shelly I.; Neil, Jeffrey J.

doi:10.1212/wnl.59.6.824

Cited by 255 publications

(161 citation statements)

References 28 publications

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“…ADC and RA were similar to that of controls, indicating that the measures normalized during the 10 days of normoxia. Normalization of ADC has been noted in both animal models subjected to varying mechanisms of injury (17,18) and human infants (19,20). Although this acute reduction in ADC after injury is related to physiologic (not structural) changes, the subsequent pseudonormalization is likely due to structural changes associated with lower tissue cell density.…”

Section: Discussionmentioning

confidence: 97%

Histopathologic correlation with diffusion tensor imaging after chronic hypoxia in the immature ferret

et al. 2011

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Articles Translational Investigation nature publishing group INTRODUCTION: chronic hypoxia in rodents induces white matter (WM) injury similar to that in human preterm infants. We used diffusion tensor imaging (DTI) and immunohistochemistry to study the impact of hypoxia in the immature ferret at two developmental time points relevant to the preterm and term brain. RESULTS: On ex vivo imaging, the apparent diffusion coefficient (aDc) was decreased throughout the WM after 10 days of hypoxia (hypoxia from postnatal day 10 (P10) to P20 and killed at P20 (early hypoxia P20)), corresponding to increased astrocytosis and decreased myelination. Diffusion values normalized after 10 days of normoxia (hypoxia from P10 to P20 and killed at P30 (early hypoxia P30)), but immunohistochemistry revealed significant astrocytosis and hypomyelination. In contrast, aDc and anisotropy were increased after 10 days of hypoxia at a later developmental time point (hypoxia from P20 to P30 and killed at P30 (late hypoxia P30)), with less astrocytosis and more prominent myelination. DISCUSSION: The patterns of alteration in imaging and histology varied in relation to the developmental time at which hypoxia occurred. Normalization of diffusion measures did not correspond to the normalization of underlying histopathology. METHODS: Ferrets were subjected to 10% hypoxia and divided into three groups: early hypoxia P20, early hypoxia P30, and late hypoxia P30.

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Section: Discussionmentioning

confidence: 97%

Histopathologic correlation with diffusion tensor imaging after chronic hypoxia in the immature ferret

et al. 2011

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“…3 For future infants with VGAM, we intend to perform MRI with diffusion weighted images about 24-48 h after each endovascular procedure. 30 This may provide information as to which procedure was responsible for any resulting cerebral infarction, and may enable alterations to the timing of procedures, the number of feeding arteries to be embolized or to the materials used for embolization (metal coils and/or NBCA-lipiodol glue).…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic disturbances associated with endovascular embolization in newborn infants with vein of Galen malformation

et al. 2006

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Objective: To examine hemodynamic changes following endovascular embolization in newborn infants with vein of Galen malformation and severe cardiac failure in the first week of life.Study design: Over a recent 5-year period, nine such infants were identified. In seven of these infants, changes in arterial blood pressure were analyzed in relation to the timing of embolization procedures.Results: A significant increase in arterial blood pressure was noted after most embolizations. In two infants, this systemic hypertension was severe and treated using intravenous antihypertensive drugs. Both infants subsequently developed complete infarction of both cerebral hemispheres with sparing of the brainstem and cerebellum. Mortality in the nine infants was 33%, and 83% of the survivors were neurologically normal or near normal at follow-up. Conclusion:The systemic hypertension observed following endovascular embolizations may provide a protective mechanism to maintain cerebral blood flow after reperfusion injury. Lowering blood pressure in this situation may therefore be detrimental.

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“…[19][20][21] Results have provided further understanding of pathogenesis and treatment in a range of neurologic disorders by providing visualization of specific white matter fiber tracts (see review by Horsfield and Jones 22 ). [23][24][25][26][27] Although injury to the corticospinal tracts is thought to be the major determinant of motor impairment in children with PVL, recent studies have shown that sensory pathways, including the posterior thalamic radiation, may be affected instead or, concurrently, 28 indicative of the complexity of white matter involvement in PVL.…”

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confidence: 99%

Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts

Nagae¹,

Hoon²,

Stashinko³

et al. 2007

American Journal of Neuroradiology

139

146

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BACKGROUND AND PURPOSE:Conventional MR imaging shows evidence of brain injury and/or maldevelopment in 70%-90% of children with cerebral palsy (CP), though its capability to identify specific white matter tract injury is limited. The great variability of white matter lesions in CP already demonstrated by postmortem studies is thought to be one of the reasons why response to treatment is so variable. Our hypothesis is that diffusion tensor imaging (DTI) is a suitable technique to provide in vivo characterization of specific white matter tract lesions in children with CP associated with periventricular leukomalacia (PVL).

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A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns

Cited by 255 publications

References 28 publications

Histopathologic correlation with diffusion tensor imaging after chronic hypoxia in the immature ferret

Histopathologic correlation with diffusion tensor imaging after chronic hypoxia in the immature ferret

Hemodynamic disturbances associated with endovascular embolization in newborn infants with vein of Galen malformation

Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts

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