A prospective, interventional study comparing the outcomes of macular hole surgery in eyes randomized to C3F8, C2F6, or SF6 gas tamponade

Rishi, Pukhraj; Rishi, Ekta; Bhende, Pramod; Bhende, Muna; Kandle, Kaustubh; Attiku, Yamini; Roy, Krishna Kanta; Shelke, Komal; Madaan, Sushant; Ratra, Dhanashree; Rao, G Sundar; Sen, Parveen; Raman, Rajiv; Rao, Chetan; Susvar, Pradeep; Khetan, Vikas; Suganeswari, G; Verma, Aditya; Muralidharan, Vinata; Saurabh, Kumar; Das, Sudipta Sekhar; Jayaprakash, Vijayvel; Suresh, Shruti; Chendilnathan, Charanya; Das, Kalpita

doi:10.1007/s10792-021-02141-0

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…6 Studies have shown that SF6 results in similar anatomical success rates for idiopathic macular holes compared with C3F8 and C2F6. 6,28 Compared with air, several studies have concluded that there is no significant difference between SF6 and air in the anatomical and functional prognosis of macular holes, at least in small-and medium-sized macular holes. 6,27,29,30 However, the mean face-down time of SF6 is longer than that of air.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Air Versus Perfluoropropane Intraocular Tamponade Combined With Vitrectomy for the Treatment of Macular Hole in High Myopia

Zhang

Yang

Wang

et al. 2023

Retina

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Purpose: To compare the efficacy of air and perfluoropropane (C3F8) with pars plana vitrectomy (PPV) in highly myopic macular holes (HMMHs) and explore the factors related to surgical prognosis.Methods: A retrospective comparison of a consecutive series of HMMHs undergone vitrectomy and internal limiting membrane peeling. According to tamponade type, they were divided into air group and C3F8 group, which were further divided into subgroups based on hole diameter or axial length (AXL). Anatomical and functional outcomes were compared between tamponades. Related factors of initial closure rate and postoperative best-corrected visual acuity (BCVA) were analyzed by logistic regression.Results: The baseline characteristics in air group (n = 63) and C3F8 group (n = 37) were similar except the age of air was older (P = 0.019). The mean follow-up period was 17.16 6 17.97 months. After surgery, the initial closure rate of air group was 85.7% and that of C3F8 group was 83.7% (P = 0.780). And the initial closure rate showed no difference between tamponades in the same subgroup classified by hole diameter or AXL (all P . 0.05). Postoperative BCVA improved significantly in both groups (P , 0.001), but no difference between them (P = 0.793). Logistic regression showed that age, minimum linear diameter, and AXL were risk factors of initial closure rate, and preoperative BCVA was the only factor associated with postoperative BCVA (all P , 0.05).Conclusion: With a long-term follow-up of HMMH, we found air had a similar tamponade effect anatomically and functionally compared with C3F8. Air may also be a good choice for patients with HMMH.

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