A Prospective Evaluation of the Pulsatile Assist Device

Zumbro, George L.; Shearer, George; Fishback, Malcolm E.; Galloway, Ronald F.

doi:10.1016/s0003-4975(10)63119-0

Cited by 23 publications

(26 citation statements)

References 6 publications

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“…Zumbro et al demonstrated that plasma hemoglobin level (a marker of blood trauma) was significantly higher in the pulsatile group compared to the group receiving NP perfusion (80 mg/dL ± 40 vs. 56 mg/dL ± 29, respectively, p < 0.01) 57 . There was no significant difference in platelet levels between the pulsatile and NP groups (159,170/mm 2 vs. 164,841/mm 2 , respectively) 57 . Other included studies did not show side effects of the PP.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies addressing the side effects of PP were excluded because they included different target population (heterogeneous surgical procedures and emergency operations) 58,59 . Zumbro et al demonstrated that plasma hemoglobin level (a marker of blood trauma) was significantly higher in the pulsatile group compared to the group receiving NP perfusion (80 mg/dL ± 40 vs. 56 mg/dL ± 29, respectively, p < 0.01) 57 . There was no significant difference in platelet levels between the pulsatile and NP groups (159,170/mm 2 vs. 164,841/mm 2 , respectively) 57 .…”

Section: Resultsmentioning

confidence: 99%

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Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Alghamdi

Latter

2006

J Cardiac Surgery

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Alghamdi

Latter

2006

J Cardiac Surgery

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“…The complex device structure and the destruction of blood cells caused by high pressure in the circulation circuit especially in front of the membrane oxygenator have posed serious problems. 6,17,18 The recently developed Korean Twin Pulse Life Support (T-PLS) device has successfully demonstrated pulsatility applying Ü ndar et al's 19 concept using energy equivalent pressure (EEP), surplus hemodynamic energy (SHE) waveform and formula. 16,20,21 The T-PLS has an added separate pulsatile blood pump in the back of the membrane oxygenator enabling effective supply of pulsatile blood flow with low inner circuit pressure and less blood cell damage compared with nonpulsatile centrifugal pumps.…”

Section: Discussionmentioning

confidence: 99%

Pulsatile Versus Nonpulsatile Flow to Maintain the Equivalent Coronary Blood Flow in the Fibrillating Heart

et al. 2007

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How much flow is required by a nonpulsatile pump to match the coronary blood flow equivalent to that of pulsatile pump? A cardiopulmonary bypass circuit from the right atrium to the ascending aorta was constructed in a ventricular fibrillation model using 13 Yorkshire swine. The animals were randomly divided into two groups: CONTROL (pulsatile T-PLS, n = 7) or EXPERIMENTAL (nonpulsatile Biopump, n = 6). The hemodynamic data at mid-LAD level was measured with a flow meter at baseline and every 20 minutes after pump flow initiation. The pump flow was started from 2 L/min in both groups (67 +/- 8 in CONTROL and 70 +/- 9 ml/kg/min in EXPERIMENTAL; p = NS), and the pump flow of the EXPERIMENTAL group was increased to match the coronary flow of the CONTROL group. To maintain mean velocity and flow in the LAD, the EXPERIMENTAL group required significantly higher pump flow at 20, 40, and 60 minutes (84 +/- 17 vs. 67 +/- 8, 87 +/- 24 vs. 67 +/- 8, 85 +/- 18 vs. 67 +/- 8 ml/kg/min, respectively, p < 0.05). The LAD diameter was substantially smaller in the CONTROL group and the resistance index was significantly lower in the CONTROL group at 80 minutes and 120 minutes after bypass (0.56 +/- 0.26 vs. 0.87 +/- 0.20 and 0.61 +/- 0.23 vs. 0.90 +/- 0.06; p < 0.05). In conclusion, we found that the nonpulsatile pump may require 25%-28% higher pump flow than the pulsatile pump to maintain equivalent coronary blood flow.

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“…Several research groups, however, have suggested that a pulsatile pump incurs more blood trauma than a nonpulsatile pump because the higher pressure in a membrane oxygenator during the CPB procedure causes higher concentrations of free hemoglobin (fHb) and higher viscoelasticity (7–9). Orime et al.…”

mentioning

confidence: 99%

Experimental Investigation of Pulsatility Effect on the Deformability and Hemolysis of Blood Cells

Kang¹,

Kim²,

Son³

et al. 2010

Artificial Organs

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In this study, we investigated the differences between pulsatile cardiopulmonary bypass (CPB) procedure and nonpulsatile CPB procedure in terms of their effects on hemolysis and deformability of red blood cells (RBCs) under various shear stress conditions. In order to research the effects on hemolysis and deformability, four parameters--free hemoglobin (fHb) concentration, normalized index of hemolysis (NIH), deformability index (DI) of RBCs, and elongation index of RBCs--have been deeply investigated. For these investigations, two randomly assigned adult mongrel dog groups-nonpulsatile group (NP, n = 6) and pulsatile group (P, n = 6)--were examined. According to our results, both types of perfusion did not show any statistical differences in terms of the concentrations of fHb as well as NIH. In addition, there were no significant differences in RBC deformability between perfusion types within an operation time of 3 h. Therefore, our studies suggest that pulsatile perfusion has no significant difference from nonpulsatile perfusion in terms of hemolysis and deformability of RBCs.

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A Prospective Evaluation of the Pulsatile Assist Device

Cited by 23 publications

References 6 publications

Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Pulsatile Versus Nonpulsatile Flow to Maintain the Equivalent Coronary Blood Flow in the Fibrillating Heart

Experimental Investigation of Pulsatility Effect on the Deformability and Hemolysis of Blood Cells

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