A prospective evaluation of posterior capsule opacification in eyes with diabetes mellitus: a case–control study

Abstract

Aim To compare the development of posterior capsule opacification (PCO) between eyes with and without diabetes mellitus after single-piece hydrophobic acrylic intraocular lens implantation 4 years postoperatively. Methods In this prospective, observational case-control study carried out at Iladevi Cataract and IOL Research Centre, Ahmedabad, India, 75 consecutive eyes with diabetes mellitus (cases) were compared with 75 age-matched eyes with age-related cataract (controls). A detailed, preoperative and posterior segment evaluation was carried out in eyes with diabetes mellitus to detect the presence or absence of diabetic retinopathy (DR). The Mann-Whitney U-test was applied to compare the differences in the development of PCO between the two groups. Results There was no difference in median PCO between cases and controls at 1 month (2.0 vs 1.50, Po0.068), but cases had a higher median PCO at 12 months (2.95 vs 1.30, Po0.001). At 4 years, there was no significant difference in median PCO between cases and controls (3.75 vs 2.25, P ¼ 0.273). The duration of diabetes increased the incidence of PCO at 4 years (P ¼ 0.02). Severity of DR had no influence on the progress of PCO at 4 years (P ¼ 0.69). Conclusion Diabetes mellitus did not increase the incidence of PCO at 4 years. The duration of diabetes increased the risk of PCO. The severity of retinopathy did not influence the development of PCO.

Anterior capsule opacification after femtosecond laser–assisted cataract surgery: Clinical classification versus Scheimpflug device densitometry values

“…Few studies have used them to analyze ACO. 9 However, despite the development of new-image analysis methods, clinical analysis remains the most widely used method of quantifying ACO. Scheimpflug imaging, such as with the Pentacam HR system (Oculus Optikger€ ate GmbH), is simple to perform and fast and has an easier learning curve than slitlamp-based photographic ACO grading systems.…”

“…Studies have sought to determine how to prevent and treat ACO and PCO, and several risk factors that predispose to the development of ACO and PCO have been identified. [1][2][3] Because of the clinical importance of both types of capsule opacification, objective quantification of ACO 3,4 and PCO [5][6][7][8][9] is of utmost importance in assessing the efficacy of different methods of evaluation. After reviewing the literature we concluded that at present, clinical quantification 2,9 is the most common method used to measure ACO after cataract surgery.…”

“…Many slitlamp-based photographic grading systems were developed to quantify PCO and are widely used in trials; these include the EPCO, POCO, POCOman, AQUA, and OSCA methods. 6,7,9 In most cases, these systems are used to measure the opacity of the capsule area within the capsulorhexis. In 2002, Sacu et al 4 used analysis of images obtained by the slitlamp for ACO quantification and found variability in the photographs and problems with the image-analysis method.…”

A Clinical Study of Complications of Cataract Surgery Sics vs. Ecce

“…This gap provides a channel for the lens epithelial cells to migrate onto the posterior capsule, causing extensive PCO. 2 The incidence of aphakic/pseudophakic glaucoma is 19%, which is varied depending on the time at which the pressure is recorded after the surgery and mode of recording.…”

Visual outcome after phacoemulsification with lens implant in diabetic and non-diabetic patients; A comparative study

“…With the new phenomenon of diabetes epidemic, more and more cataracts are presenting with diabetes and so more and more surgery is needed 3. Cataract surgery in diabetics is indicated not only to improve visual acuity, but also to allow assessment and treatment of retinopathy 4. Cataract surgeries are often carried out earlier amongst diabetics in developed countries to allow diagnosis and treatment of retinopathy and maculopathy 5.…”