A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study

Chajès, Véronique; Assi, Nada; Biessy, Carine; Ferrari, Pietro; Rinaldi, Sabina; Slimani, Nadia; Lenoir, Gilbert; Baglietto, Laura; His, Mathilde; Boutron‐Ruault, Marie‐Christine; Trichopoulou, Antonia; Λάγιου, Παγώνα; Katsoulis, Michail; Kaaks, Rudolf; Kühn, Tilman; Panico, Salvatore; Pala, Valeria; Masala, Giovanna; Bueno‐de‐Mesquita, H. Bas; Peeters, Petra H.M.; Gils, Carla van; Hjartåker, Anette; Olsen, Anja; Barnung, Runa Borgund; Barricarte, Aurelio; Redondo-Sánchez, Daniel; Menéndez, Virginia; Amiano, Pilar; Wennberg, Maria; Key, Timothy J.; Khaw, Kay Tee; Merritt, Melissa A.; Riboli, Elio; Gunter, Marc J.; Romieu, Isabelle

doi:10.1093/annonc/mdx482

Cited by 36 publications

(57 citation statements)

References 21 publications

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“…For the purpose of this study, the 395 available blood samples were shipped to the International Agency for Research on Cancer (IARC) and stored at −80 °C until analyzed. As previously described [ 18 ], total lipids were extracted from serum samples, the phospholipid fraction was purified by adsorption chromatography, and Methyl-Prep II was used for the thansmethylation of fatty acids into fatty acid methyl esters. Fatty acid methyl esters were eluted on a gas chromatograph 7890A (Agilent Technologies, Santa Clara, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study

et al. 2018

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There have been increases in the incidence of obesity in Lebanon over the past few decades. Fatty acid intake and metabolism have been postulated to influence obesity, but few epidemiological studies have been conducted. The aim of this study was to investigate the correlation between serum fatty acid levels and indicators of obesity in a cross-sectional study nested within a cohort of 501 Lebanese adults residing in Greater Beirut. A total of 395 available serum samples (129 men, 266 women) were profiled for phospholipid fatty acid composition. Spearman correlation coefficients adjusted for relevant confounders and corrected for multiple testing were calculated between serum fatty acids, desaturation indices, and indicators of adiposity (body mass index (BMI) and waist). BMI was significantly positively correlated with saturated fatty acids in men (r = 0.40, p < 0.0001, q < 0.0001) and women (r = 0.33, p < 0.0001, q < 0.0001). BMI was significantly positively correlated with monounsaturated fatty acid palmitoleic acid in women (r = 0.15, p = 0.01, q = 0.03). This study suggests that high blood levels of some saturated fatty acids and the monounsaturated fatty acid palmitoleic acid, likely derived from both dietary intakes of saturated fatty acids and endogenous lipogenesis, may have been associated with adiposity in the Lebanese population. The causality of these associations needs to be explored in experimental settings.

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Section: Methodsmentioning

confidence: 99%

Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study

et al. 2018

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“…Therefore, the fatty acid profile in biological samples is a more accurate measure that reflects the interaction between dietary intake, de novo lipogenesis and the activity of different enzymes involved in this metabolic process [ 14 ]. Although data from a meta-analysis of prospective studies found no association between serum levels of SFAs, MUFAs and PUFAs and risk of BC [ 15 ], more recent studies have described positive associations with circulating levels of several SFAs [ 16 , 17 ], palmitoleic acid [ 18 ], some trans fatty acids [ 17 , 18 , 19 ] and the ratio of palmitoleic acid to palmitic acid (DI 16 ) [ 18 ], as well as an inverse association with n-3 PUFAs among overweight/obese women [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been described that the expression of fatty acid metabolism proteins differs with respect to intrinsic molecular BC subtype [ 21 ]. To date, very few studies have analyzed the association between circulating fatty acids and BC risk defined by hormonal receptor status [ 16 , 18 ], and, to our knowledge, none of them have studied this relationship taking into account the HER2 status. The objective of the present study was to investigate the association between fatty acids assessed in serum phospholipids and BC risk, as well as to evaluate whether this association differed according to specific pathological BC subtype.…”

Section: Introductionmentioning

confidence: 99%

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

et al. 2020

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This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.

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“…The FA composition of plasma phospholipids reflects medium‐term intake of some FAs, particularly of those not endogenously synthesized . Furthermore, the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs), also known as the desaturation index, measured in blood phospholipids is used as surrogate marker of the activity of hepatic stearoyl‐CoA desaturase‐1 (SCD‐1), a key enzyme in the synthesis of MUFAs from SFAs, which has previously been associated with cancer risk and mortality …”

Section: Introductionmentioning

confidence: 99%

“…21,22 Furthermore, the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs), also known as the desaturation index, measured in blood phospholipids is used as surrogate marker of the activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in the synthesis of MUFAs from SFAs, 23,24 which has previously been associated with cancer risk and mortality. 25,26 We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to estimate the association of specific plasma phospholipid levels of relevant FAs and PC risk. In addition, we used the desaturation index as an indicator of endogenous MUFA synthesis 23,27 to investigate the association between fat metabolism and pancreatic carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Matejcic

Lesueur

Biessy

et al. 2018

Intl Journal of Cancer

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There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (OR [odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41-0.98; p = 0.036), n-3 polyunsaturated α-linolenic acid (OR = 0.60; 95%CI = 0.39-0.92; p = 0.02) and docosapentaenoic acid (OR = 0.52; 95%CI = 0.32-0.85; p = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (OR = 3.00; 95%CI = 1.13-7.99; p = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (OR = 0.37; 95%CI = 0.17-0.81; p = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (OR = 3.40; 95%CI = 1.39-8.34; p = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

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A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study

Cited by 36 publications

References 21 publications

Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study

Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study

Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype

Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

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