A prospective, double-blind study on the efficacy of the bioline surface-heparinized extracorporeal perfusion circuit

The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation

“…According to the manufacturer, Softline® is a polymer comprised of hydrophilic and hydrophobic areas, which reduce adhesion and activation of cells and activation of the coagulation and complement system. Using Softline®-coating, cell activation in ECC is reduced as shown in studies reporting preservation of platelet and leukocyte counts using Softline® and similar circuit-coatings [24,25]. This is further supported by our results showing no statistically significant increases in the formation of leukocyte-platelet aggregates during ex 6.…”

Cardiopulmonary Bypass

“…They also found lower TNF-α levels. Interestingly, they did not show a difference between the group treated with an entire circuit bonded with heparin and the group in which only the oxygenator and fi lter were treated [187].…”

“…Neither study, however, demonstrated that the suppression of infl ammation improved time to extubation, intensive care unit stay, or time to discharge. Palatianos and colleagues, on the other hand, did demonstrate a decrease in intensive care unit stay in patients treated with a heparin-coated circuit [187]. They also found lower TNF-α levels.…”

ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

“…Most in vitro or animal models demonstrate benefits of heparin coating including reduced soluble thrombin production, platelet binding, and D-dimer production [12,[15][16][17][18][19]20]. With respect to inflammation, most studies demonstrate reduced inflammatory response, particularly in the interleukins, alternative complement pathway and polymorphonuclear cells, compared to controls and other coating systems [12,[20][21][22][23][24][25]26]. Meta-analyses of the benefits of heparin coating have consistently found improvements in transfusion requirements, arrhythmias, ventilator times, and lengths of stay in the hospital or ICUs when using heparin-coated circuits for cardiopulmonary bypass [17,27,28,29].…”