A prospective controlled study comparing brush and bile exfoliative cytology for diagnosing bile duct strictures.

Abstract

(16), bile duct cancer (nine), ampullary cancer (three) and metastases in (one)) and three were because of benign disease (sclerosing cholangitis, Mirizzi syndrome, and villous adenoma one each). The three patients with benign strictures all underwent surgery and had histological confirmation of benign disease. Of the 29 patients with malignancy histological confirmation was obtained in 16 patients. This was obtained from biopsies at operation, under ultrasound or computed tomography guidance, endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography in eight patients, from resected surgical specimens in six patients and at necropsy in two. In 13 patients the diagnosis was based on the appearance of a malignant stricture at cholangiography along with an ultrasound and/or computed tomography scan evidence of a mass and disease progression leading to death (Table I).All patients had brush and bile cytology performed during the same diagnostic procedure. The samples were collected by the gastroHepatobiliary and Liver

Endoscopic transpapillary bile duct biopsy with the combination of intraductal ultrasonography in the diagnosis of biliary strictures

“…[1][2][3][4][5][6][7][8][9][10][11][12] Transpapillary bile duct biopsy during endoscopic retrograde cholangiopancreatography (ERCP) is a simple, safe, and effective way to biopsy these strictures. [1][2][3][4][5][6][7] However, when biopsy fails to demonstrate malignancy, there are no clear guidelines for further management of these patients.…”

Wisteria floribunda agglutinin-positive mucin 1 is a sensitive biliary marker for human cholangiocarcinoma

“…[4][5][6] Regarding the diagnosis of CC, biliary cytology and brush cytology are performed routinely, although the sensitivity of exfoliative biliary cytology is generally low (40%-69%). [10][11][12] Thus, a novel biological diagnostic marker for CC is needed to provide a fully workable method to identify the lesion at as early a stage as possible.…”

Biliary Tract Brush Cytology

“…5,10,16,19,22 Most of the reported series have utilized a combination of these procedures and methods for cytologic evaluation. 6,11 Even in studies involving primarily the biliary tree by brushings, the specimens studied were cytocentrifuge preparations from brushes rather than direct smears. 4,18 In our study, all 175 cases were direct smears from the endoscopic brush.…”