A prospective comparison study for predicting circumferential resection margin between preoperative MRI and whole mount sections in mid-rectal cancer: Significance of different scan planes

Tumor Volume Changes Assessed by Three-Dimensional Magnetic Resonance Volumetry in Rectal Cancer Patients After Preoperative Chemoradiation: The Impact of the Volume Reduction Ratio on the Prediction of Pathologic Complete Response

“…In this study, clinical T and N staging were done in all patients using the following modalities: digital rectal examination, TRUS, and pelvic MRI, after which the findings were discussed at multidisciplinary team meetings consisting of colorectal surgeons, radiologists, medical oncologists, and radiation oncologists (19)(20)(21). At these meetings, the MRI findings were used mainly as the basis for preoperative clinical staging.…”

Magnetic resonance imaging (MRI) in rectal cancer: a comprehensive review

“…As mentioned above, what constitutes a threatened margin has been the subject of several studies and the lower the threshold, the higher the sensitivity at the cost of specificity. At most centres, a margin of 1 mm is considered the threshold, yet others have chosen other thresholds [39–41]. In order to obtain the best results both the imaging plane and the slice thickness of the imaging on T2-weighted imaging should be optimised in the same way as when involvement of other neighbouring structures is studied.…”

“…In this, the largest published study regarding the accuracy of staging of rectal cancer with the primary objective of assessing the depth of tumour extension in rectal cancer, T4-staging was done accurately in only five out of 14 cases [14]. One of the reasons for staging inaccuracies in everyday practice is probably the lack of imaging in the optimal plane [15–17]. One of the aforementioned studies [15] showed that among patients with a higher inaccuracy of staging, the number of sequences was higher and imaging was more commonly performed with gadolinium contrast enhancement.…”

The prognostic impact of the number of lymph nodes retrieved after neoadjuvant chemoradiotherapy with mesorectal excision for rectal cancer

“…The sections were examined microscopically according to the TNM classification for the largest tumor diameter, depth of tumor invasion and number of retrieved and metastatic nodes. The resection margin status (circumferential, proximal, and distal) was also examined [21].…”