A prospective comparison of total protein/creatinine ratio versus 24-hour urine protein in women with suspected preeclampsia

Waugh, Jason; Maybury, Helena; Shennan, Andrew

doi:10.1016/j.ajog.2004.05.040

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Consistent with previous studies, [2][3][4][5][6][7][8][9][10][11] our data demonstrated a strong correlation between the two methods in pregnant women suspected of having pre-eclampsia. It suggests that the random urinary p:c ratio is an accurate test for discriminating between significant and insignificant proteinuria.…”

Section: Discussionsupporting

confidence: 94%

“…Several studies have suggested an acceptable correlation between single-voided p:c ratio and 24-h urine protein in pregnant patients. [2][3][4][5][6][7][8][9][10][11] Nevertheless, the results reported may be limited by examining patients with a different underling disease in one study 11 and not having a large enough sample in another one. 10 Some studies were conducted on hospitalised pregnant patients with suspected pre-eclampsia, whose results may not be applicable for outpatient pregnant women.…”

Section: Introductionmentioning

confidence: 99%

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Random urine protein to creatinine ratio as a diagnostic method of significant proteinuria in pre‐eclampsia

Zadehmodarres¹,

Razzaghi²,

Habibi

et al. 2006

Aust NZ J Obst Gynaeco

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There is a strong correlation between 24-h urine protein excretion and single-voided urine p:c ratio in women suspected of having pre-eclampsia. A single-voided p:c ratio of >or=0.2 mg/mg is highly predictive for significant proteinuria. However, this test was not found to be a reasonable alternative to 24-h urine collection; and it must be followed by 24-h urine collection in a clinically suspect patient with a p:c ratio of <0.2 mg/mg.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Random urine protein to creatinine ratio as a diagnostic method of significant proteinuria in pre‐eclampsia

Zadehmodarres¹,

Razzaghi²,

Habibi

et al. 2006

Aust NZ J Obst Gynaeco

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“…Proteinuria is a criterion for diagnosis in the most widely accepted definitions of pre-eclampsia, but the threshold for significance remains controversial [1,2]. Recent guidelines from the National Institute for Health and Clinical Excellence (NICE) for the management of hypertensive disorders in pregnancy have highlighted that the prognostic value of different quantities of urinary protein is unclear and recommend research to identify diagnostic thresholds of proteinuria which are accurate in predicting clinically important outcomes, thus allowing interventions based on these thresholds to be evaluated in randomised controlled trials [3] .…”

Section: Introductionmentioning

confidence: 99%

Association of Proteinuria Threshold in Pre-Eclampsia with Maternal and Perinatal Outcomes: A Nested Case Control Cohort of High Risk Women

et al. 2013

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ObjectivesTo evaluate occurrence of adverse maternal and perinatal outcomes with different thresholds of proteinuria (300-499mg and ≥500mg/24 hours) in pre-eclamptic women, comparing outcomes against women with chronic and gestational hypertension.DesignSecondary analysis of the Vitamins in Pre-Eclampsia Trial.Setting25 UK hospitals in ten geographical areas.Population946 women with pre-existing risk factors for pre-eclampsia.MethodsWomen with pre-eclampsia and proteinuria 300-499mg/24h (PE300, referent group, n=60) or proteinuria ≥500 mg/24h (PE500, n=161) were compared with two groups of non-proteinuric women with chronic hypertension (CHT, n=615) or gestational hypertension (GH, n=110).Main Outcome MeasuresMaternal: progression to severe hypertension. Perinatal: small for gestational age (SGA) <5th centile, gestation at delivery.ResultsSevere hypertension occurred more frequently in PE500 (35%) and PE300 (27%) than CHT (5.9%; P≤0.01) and GH (10%; p≤0.001). Gestation at delivery was earlier in PE500 (33.2w) than PE300 (37.3w; P≤0.001), and later in CHT (38.3w; P≤0.05) and GH (39.1w; P≤0.001). SGA infants were more frequent in PE300 (32%) than in CHT (13.3%; P≤0.001) and GH (16.5%; P≤0.05). Women in PE500 were more likely to have a caesarean section than PE300 (78% vs. 48%; P≤0.001), and to receive magnesium sulphate (17% vs. 1.7%, P≤0.05).ConclusionWomen with PE300 have complication rates above those of women managed as out-patients (GH and CHT), meriting closer surveillance and confirming 300 mg/d as an appropriate threshold for determining in-patient management. Adverse perinatal outcomes are higher still in women with PE500.

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“…5,6 However, there is no consensus regarding accuracy of protein/creatinine ratio in predictions of 300 mg of protein in 24-hour urine collection during pregnancy. [7][8][9][10][11][12][13][14][15] The standard practice of collecting a 24-hour urine for protein is cumbersome, time consuming, and inconvenient. Although many women with suspected preeclampsia are hospitalized, some women are managed as outpatients and collect a 24-hour urine sample.…”

mentioning

confidence: 99%

Protein/Creatinine Ratio in Preeclampsia

Papanna

Mann

Kouides

et al. 2008

Obstetrics &Amp; Gynecology

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A prospective comparison of total protein/creatinine ratio versus 24-hour urine protein in women with suspected preeclampsia

Cited by 6 publications

References 4 publications

Random urine protein to creatinine ratio as a diagnostic method of significant proteinuria in pre‐eclampsia

Random urine protein to creatinine ratio as a diagnostic method of significant proteinuria in pre‐eclampsia

Association of Proteinuria Threshold in Pre-Eclampsia with Maternal and Perinatal Outcomes: A Nested Case Control Cohort of High Risk Women

Protein/Creatinine Ratio in Preeclampsia

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