A prospective comparison of 18F-fluorodeoxyglucose positron emission tomography-computed tomography, magnetic resonance imaging and whole-body planar radiographs in the assessment of bone disease in newly diagnosed multiple myeloma

18F‐fluoro‐deoxyglucose positron emission tomography in assessment of myeloma‐related bone disease: A systematic review

“…The studies with a methodological quality above average were the studies by Bredella et al, 10 Fonti et al, 14 Hur et al, 16,17 Schirrmeister et al, 23,24 and Zamagni et al 4,21 Comparison of 18 FDG PET or PET-CT and Conventional Imaging at Staging Of the 18 studies conducted, concordance assessment between WBXR and 18 FDG PET scan was possible in 7 (concerning 242 patients). In 6 out of these 7 studies, 18 FDG PET (with or without CT) scan showed more lytic lesions then conventional WBXR with the exception of lytic lesions located in the skull 4,[9][10][11]19,21,23,24 (Table 5). Two studies compared 18 FDG PET-CT scan with WBXR.…”

“…In addition, there were some reports on the prognostic value of 18 F-fluoro-deoxyglucose positron emission tomography ( 18 FDG PET)-computed tomography (CT) in newly diagnosed patients that appeared superior to WBXR. 3,4 Moreover, the predictive value of normalized 18 FDG uptake during therapy was associated with improved survival outcomes. This finding is intriguing because in contrast to CT and magnetic resonance imaging (MRI), 18 FDG PET or PET-CT quantifies metabolic function due to increased glycolysis and thereby active disease.…”

“…Finally, 18 studies involving 798 patients were included in this systematic review (Figure 1). 3,4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] There was no disagreement between the reviewers regarding the inclusion of the articles. The characteristics of the included studies are presented in Table 2.…”

“…Fonti, 2007 All focal areas visible on at least 2 contiguous PET slices showing a maximal SUV of !2.5 and corresponding CT abnormalities not attributable to benign bone pathologies. Zamagni, 2007 All nonphysiologic areas of increases 18 FDG uptake if SUV max based on body weight was >2.5 and a lytic bone lesion was recognized on the corresponding CT images. Salaun, 2008 Not mentioned Bartel, 2009 Hypermetabolic FLs (PET-FL) were defined as being more intense than background marrow uptake and described by location, number, size, and associated standardized uptake values (SUV-FL).…”

Whole body magnetic resonance imaging in newly diagnosed multiple myeloma: early changes in lesional signal fat fraction predict disease response

“…Radiological techniques have long been a part of disease assessments; plain radiographic skeletal survey and magnetic resonance imaging (MRI) of the spine have an established role in the diagnosis, staging and assessment of insufficiency fracture risk of patients (Durie et al , 2006; D'Sa et al , 2007; Hanrahan et al , 2010). The use of cross‐sectional imaging techniques [computed tomography (CT), positron emission tomography (PET)‐CT and MRI] are confirmed to be more sensitive than plain radiography in the detection of bone lesions (Zamagni et al , 2007; Bartel et al , 2009; Regelink et al , 2013; Waheed et al , 2013). Importantly, the detection of more than one focal lesion (FL) on cross‐sectional imaging is now considered to fulfill the criteria for symptomatic disease deserving of treatment (Rajkumar et al , 2014).…”