A Prospective, Comparative Study of the Immune Response to Inactivated Influenza Vaccine in Pediatric Liver Transplant Recipients and Their Healthy Siblings

Madan, Rebecca Pellett; Tan, Maria; Fernández-Sesma, Ana; Moran, Thomas M.; Emre, Sükrü; Campbell, Andrew; Herold, Betsy C.

doi:10.1086/527391

Cited by 64 publications

(54 citation statements)

References 34 publications

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“…However, characteristics of the cellular immune response to influenza vaccine in immunocompromised patients, such in SOT recipients [4,23,37,38] are not widely reported. Because of lower CD4+ T-cell counts, we expected lower influenza specific T-cell mediated responses in patients receiving ATG, but this was not observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Humoral, T-cell and B-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-T cell therapies

Héquet

Pascual

Lartey

et al. 2016

Vaccine

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Section: Discussionmentioning

confidence: 99%

Humoral, T-cell and B-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-T cell therapies

Héquet

Pascual

Lartey

et al. 2016

Vaccine

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“…Another study compared the immune response to influenza vaccine in pediatric liver transplant recipients and their healthy siblings. 24 Thirty transplant recipients achieved similar seroprotection and seroconversion compared with their 13 healthy siblings. Although not significant, as in our study, there was a trend toward lower seroconversion rates among transplant recipients.…”

Section: Geometric Mean Ratio (Gmr)mentioning

confidence: 92%

Immune response to influenza vaccination in children treated with methotrexate or/and tumor necrosis factor-α inhibitors

et al. 2011

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“…Similar to studies in immune competent individuals, responses to influenza A strains in pediatric transplant recipients are generally superior to responses to influenza B strains. Madan and colleagues looked at both cellular and humoral responses in a cohort of long-term pediatric liver transplant recipients (mean 52.3 months after transplant) and showed similar seroprotection and seroconversion, but decreased interferon gamma production compared to healthy sibling controls (64).…”

Section: Pediatric Issuesmentioning

confidence: 99%

Influenza Vaccination in the Organ Transplant Recipient: Review and Summary Recommendations

Kumar

Blumberg

Danziger‐Isakov

et al. 2011

American Journal of Transplantation

155

164

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Influenza virus causes a spectrum of illness in transplant recipients with a high rate of lower respiratory disease. Seasonal influenza vaccination is an important public health measure recommended for transplant recipients and their close contacts. Vaccine has been shown to be safe and generally well tolerated in both adult and pediatric transplant recipients. However, responses to vaccine are variable and are dependent on various factors including time from transplantation and specific immunosuppressive medication. Seasonal influenza vaccine has demonstrated safety and no conclusive evidence exists for a link between vaccination and allograft dysfunction. Annually updated trivalent inactivated influenza vaccines have been available and routinely used for several decades, although newer influenza vaccination formulations including high-dose vaccine, adjuvanted vaccine, quadrivalent inactivated vaccine and vaccine by intradermal delivery system are now available or will be available in the near future. Safety and immunogenicity data of these new formulations in transplant recipients requires investigation. In this document, we review the current state of knowledge on influenza vaccines in transplant recipients and make recommendations on the use of vaccine in both adult and pediatric organ transplant recipients.

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A Prospective, Comparative Study of the Immune Response to Inactivated Influenza Vaccine in Pediatric Liver Transplant Recipients and Their Healthy Siblings

Cited by 64 publications

References 34 publications

Humoral, T-cell and B-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-T cell therapies

Humoral, T-cell and B-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-T cell therapies

Immune response to influenza vaccination in children treated with methotrexate or/and tumor necrosis factor-α inhibitors

Influenza Vaccination in the Organ Transplant Recipient: Review and Summary Recommendations

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