A prospective comparative analysis of the accuracy of HistoScanning and multiparametric magnetic resonance imaging in the localization of prostate cancer among men undergoing radical prostatectomy

Orczyk, Clément; Rosenkrantz, Andrew B.; Deng, Fang; Melamed, Jonathan; Babb, James S.; Wysock, James S.; Kheterpal, Emil; Huang, William C.; Stifelman, Michael; Lepor, Herbert; Taneja, Samir S.

doi:10.1016/j.urolonc.2015.07.004

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…The difference, however, is that one is a positive correlation, while the other is a negative correlation. Some studies have shown that the Cho+Cr/Cit ratio in prostate cancer tissue detected by MRI was positively correlated with Gleason score [28,29]. This indicates that following Gleason score elevation, Cho peak enlarged, while Cit peak decreased in prostate cancer area, which further supported our conclusions.…”

Section: Discussionsupporting

confidence: 89%

The Role of Tumor Oxygenation Tested by Magnetic Resonance Imaging (MRI) in Prostate Cancer Grading

et al. 2019

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Background Prostate cancer is a common malignant tumor in males. Prostate cancer grading is an important basis for evaluation of invasion. The purpose of this article was to use dynamic enhanced scan magnetic resonance imaging (MRI) to quantitatively investigate the relationship between tumor oxygenation value and prostate cancer pathological Gleason score. Material/Methods A total of 312 prostate cancer patients diagnosed by needle biopsy who received MRI dynamic enhanced scan were enrolled in this study. Multiparameter oxygen concentration image based on MRI was applied to test pO2 in tumors. Multiple spin resonance image relaxation time edit sequence and weak field diffusion model were used to estimate oxygen saturation level and pO2. hematoxylin and eosin staining and Gleason score were used to determine biological behavior and prognosis. Results According to the Gleason score system, there were 28 cases with a score of 10, 112 cases with a score of 9, 56 cases with a score of 8, and 116 cases with a score lower than 7. The enrolled patients were divided into groups: 116 cases into the middle-to-well differentiation group (Gleason score ≤7) and 196 cases into the poorly differentiation group (Gleason score at 8 to 10). Prostate cancer tumor oxygenation value was positively correlated with Gleason score (r=0.349, P <0.05) or PSA (r=0.432, P <0.05). Tumor oxygenation value in Gleason ≤7 group was obviously different from that in the group with Gleason score between 9 and 10 ( P <0.05). Conclusions Tumor oxygenation value in prostate cancer was positively correlated with Gleason score. Tumor oxygenation value might be useful in clinics to evaluate prostate cancer grading and prognosis.

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Section: Discussionsupporting

confidence: 89%

The Role of Tumor Oxygenation Tested by Magnetic Resonance Imaging (MRI) in Prostate Cancer Grading

et al. 2019

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“…Finally, given that mpMRI outperforms HS for disease evaluation, the role of HS in disease detection and biopsy guidance remains dubious. [9,27,50]…”

Section: Discussionmentioning

confidence: 99%

“…Orcyzk et al compared HS disease detection in 31 men undergoing RP with preoperative multiparametric MRI (mpMRI). [27] In 31 men, 84 tumors were identified on RP. Histoscanning™ detected 36 of these, demonstrating CDR of 42.9%.…”

Section: Detection Of Prostate Cancermentioning

confidence: 99%

HistoScanningTM to Detect and Characterize Prostate Cancer—a Review of Existing Literature

Wysock

Orczyk

et al. 2017

Curr Urol Rep

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Eighteen original, English language articles were found to adequately study the use of HistoScanning™ for prostate cancer diagnosis in the clinical setting. The articles were found by conducting a bibliographic search of PubMed in April 2017 in addition to utilizing references. The studies are divided into four groups based on study design. Study methods and quantitative data are summarized for each of the relevant articles. The results are synthesized to evaluate the utility of HistoScanning™ for the purpose of diagnosing PCa. Despite the promise of early pilot studies, there is a lack of consistent results across a number of further investigations of HistoScanning™. This becomes increasingly evident as study size increases. As various other modern diagnostic modalities continue to develop, the future of HistoScanning™, both alone and in conjunction with these technologies, remains unclear.

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Imaging of the prostate

Watson

Mertan

Borofsky

et al. 2018

Evidence‐Based Urology

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A prospective comparative analysis of the accuracy of HistoScanning and multiparametric magnetic resonance imaging in the localization of prostate cancer among men undergoing radical prostatectomy

Cited by 8 publications

References 26 publications

The Role of Tumor Oxygenation Tested by Magnetic Resonance Imaging (MRI) in Prostate Cancer Grading

The Role of Tumor Oxygenation Tested by Magnetic Resonance Imaging (MRI) in Prostate Cancer Grading

HistoScanningTM to Detect and Characterize Prostate Cancer—a Review of Existing Literature

Imaging of the prostate

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