A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Viet Nam

Tien, Nguyen Thi Kim; Luxemburger, Christine; Toàn, Nguyễn Trọng; Pollissard-Gadroy, Laurence; Huong, Vû Thi Quê; Be, Pham Van; Rạng, Nguyễn Ngọc; Wartel, Tram-Anh; Lang, Jean

doi:10.1016/j.trstmh.2010.06.003

Cited by 58 publications

(71 citation statements)

References 19 publications

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“…There was a slow increase in seroprevalence rates (slower than in other countries) [28], [30], [35], [36], consistent with the peak age incidence for clinically apparent dengue disease in young adults. These findings indicate a high level of DENV exposure in the community and show a different distribution to that observed in some other countries in the Asia–Pacific region, where seroprevalence is high in children, for example Thailand [40], [41], Vietnam [42], [43], and Indonesia [44]. However, Singapore has an even lower age-stratified seroprevalence in children than Malaysia [45] and has a higher peak age incidence for clinically apparent dengue disease [46].…”

Section: Discussionmentioning

confidence: 69%

Epidemiology of Dengue Disease in Malaysia (2000–2012): A Systematic Literature Review

Mohd-Zaki

Brett²,

Ismail³

et al. 2014

PLoS Negl Trop Dis

116

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A literature survey and analysis was conducted to describe the epidemiology of dengue disease in Malaysia between 2000 and 2012. Published literature was searched for epidemiological studies of dengue disease, using specific search strategies for each electronic database; 237 relevant data sources were identified, 28 of which fulfilled the inclusion criteria. The epidemiology of dengue disease in Malaysia was characterized by a non-linear increase in the number of reported cases from 7,103 in 2000 to 46,171 in 2010, and a shift in the age range predominance from children toward adults. The overall increase in dengue disease was accompanied by a rise in the number, but not the proportion, of severe cases. The dominant circulating dengue virus serotypes changed continually over the decade and differed between states. Several gaps in epidemiological knowledge were identified; in particular, studies of regional differences, age-stratified seroprevalence, and hospital admissions.Protocol registrationPROSPERO #CRD42012002293

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Section: Discussionmentioning

confidence: 69%

Epidemiology of Dengue Disease in Malaysia (2000–2012): A Systematic Literature Review

Mohd-Zaki

Brett²,

Ismail³

et al. 2014

PLoS Negl Trop Dis

116

View full text Add to dashboard Cite

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“…This was proposed to be a result of heterotypic cross-immunity, as described above. A plot of the inapparent rate against previous dengue incidence reported in the longitudinal cohorts with sufficient data (Nicaragua, Peru, Thailand, and Vietnam) (30, 35, 39, 41, 42, 52), all show the same positive relationship between the incidence of infection the previous year and the inapparent rate in the current year (Figure 2). However, the strength of the relationship seems proportional to the seroprevalence.…”

Section: Potential Explanations For Differences In Observed Inapparenmentioning

confidence: 67%

Epidemiological Risk Factors Associated with High Global Frequency of Inapparent Dengue Virus Infections

et al. 2014

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Dengue is a major international public health concern, and the number of outbreaks has escalated greatly. Human migration and international trade and travel are constantly introducing new vectors and pathogens into novel geographic areas. Of particular interest is the extent to which dengue virus (DENV) infections are subclinical or inapparent. Not only may such infections contribute to the global spread of DENV by human migration, but also seroprevalence rates in naïve populations may be initially high despite minimal numbers of detectable clinical cases. As the probability of severe disease is increased in secondary infections, populations may thus be primed, with serious public health consequences following introduction of a new serotype. In addition, pre-existing immunity from inapparent infections may affect vaccine uptake, and the ratio of clinically apparent to inapparent infection could affect the interpretation of vaccine trials. We performed a literature search for inapparent DENV infections and provide an analytical review of their frequency and associated risk factors. Inapparent rates were highly variable, but “inapparent” was the major outcome of infection in all prospective studies. Differences in the epidemiological context and type of surveillance account for much of the variability in inapparent infection rates. However, one particular epidemiological pattern was shared by four longitudinal cohort studies: the rate of inapparent DENV infections was positively correlated with the incidence of disease the previous year, strongly supporting an important role for short-term heterotypic immunity in determining the outcome of infection. Primary and secondary infections were equally likely to be inapparent. Knowledge of the extent to which viruses from inapparent infections are transmissible to mosquitoes is urgently needed. Inapparent infections need to be considered for their impact on disease severity, transmission dynamics, and vaccine efficacy and uptake.

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“…2,3 Globally, an estimated four billion persons are at risk for DENV infection, and there are an estimated 390 million annual DENV infections and 96 million dengue cases. 4 From prospective community and school-based cohort studies, it has been possible to obtain estimates for the incidence of DENV infection and disease for sites in southeast Asia [5][6][7][8][9][10] and Latin America. [11][12][13] Although dengue is emerging in the Indian subcontinent and is considered a major health issue, we do not have estimates of the true burden of DENV infection and disease in this region.…”

Section: Introductionmentioning

confidence: 99%

Burden of Dengue Infection and Disease in a Pediatric Cohort in Urban Sri Lanka

Tissera¹,

Amarasinghe²,

Silva³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Abstract. Dengue is the most significant arthropod-borne viral infection of humans. Persons infected with dengue viruses (DENV) have subclinical or clinically apparent infections ranging from undifferentiated fever to dengue hemorrhagic fever/shock syndrome. Although recent studies estimated that the Indian subcontinent has the greatest burden of DENV infection and disease worldwide, we do not have reliable, population-based estimates of the incidence of infection and disease in this region. The goal of this study was to follow-up a cohort of 800 children living in a heavily urbanized area of Colombo, Sri Lanka to obtain accurate estimates of the incidence of DENV infection and disease. Annual blood samples were obtained from all children to estimate dengue seroprevalence at enrollment and to identify children exposed to new DENV infections during the study year. Blood was also obtained from any child in whom fever developed over the course of the study year to identify clinically apparent DENV infections. At enrollment, dengue seroprevalence was 53.07%, which indicated high transmission in this population. Over the study year, the incidence of DENV infection and disease were 8.39 (95% confidence interval = 6.56-10.53) and 3.38 (95% confidence interval = 2.24-4.88), respectively, per 100 children per year. The ratio of clinically inapparent to apparent infections was 1.48. These results will be useful for obtaining more accurate estimates of the burden of dengue in the region and for making decisions about testing and introduction of vaccines.

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A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Viet Nam

Cited by 58 publications

References 19 publications

Epidemiology of Dengue Disease in Malaysia (2000–2012): A Systematic Literature Review

Epidemiology of Dengue Disease in Malaysia (2000–2012): A Systematic Literature Review

Epidemiological Risk Factors Associated with High Global Frequency of Inapparent Dengue Virus Infections

Burden of Dengue Infection and Disease in a Pediatric Cohort in Urban Sri Lanka

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