A prospective cohort analysis of residential radon and UV exposures and malignant melanoma mortality in the Swiss population

Boz, Seçkin; Berlin, Claudia; Kwiatkowski, Marek; Bochud, Murielle; Bulliard, Jean‐Luc; Zwahlen, Marcel; Röösli, Martin; Vienneau, Danielle

doi:10.1016/j.envint.2022.107437

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Exposure to radon is a known cause of lung cancer [ 1 , 2 ] and several epidemiological studies implicate radon exposure in breast cancer [ 3 ], malignant melanoma [ 4 ], and pulmonary function in COPD patients [ 5 ]. One recent observational study ( N = 68) demonstrated elevated inflammatory markers (C-reactive protein and interleukin-1 β ) in children and adolescents (ages 6–14 years old) exposed to radon [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Geologic, seasonal, and atmospheric predictors of indoor home radon values

Hahn

Haneberg

Stanifer

et al. 2023

Environ. Res.: Health

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Exposure to tobacco smoke and radon cause lung cancer. Radioactive decay of naturally occurring uranium in bedrock produces radon. Seasonality, bedrock type, age of home, and topography have been associated with indoor radon, but the research is mixed. The study objective was to examine the relationships of geologic (soil radon and bedrock) and seasonal (warm and cold times of the year) factors with indoor home radon values in citizen scientists’ homes over time, controlling for atmospheric conditions, topography, age of home, and home exposure to tobacco smoke. We collected and analyzed indoor radon values, soil radon gas concentrations, and dwelling- and county-level geologic and atmospheric conditions on 66 properties in four rural counties during two seasons: 1) summer 2021 (n = 53); and 2) winter/spring 2022 (n = 52). Citizen scientists measured indoor radon using Airthings radon sensors, and outdoor temperature and rainfall. Geologists obtained soil radon measurements using RAD7 instruments at two locations (near the dwelling and farther away) at each dwelling, testing for associations of indoor radon values with soil values, bedrock type, topography, and atmospheric conditions. Bedrock type, near soil radon levels, home age, and barometric pressure were associated with indoor radon. Dwellings built on carbonate bedrock had indoor radon values that were 2.8 pCi/L (103.6 Bq/m3) higher, on average, compared to homes built on siliclastic rock. Homes with higher near soil radon and those built < 40 ago were more likely to have indoor radon > 4.0 pCi/L (148 Bq/m3). With higher atmospheric barometric pressure during testing, observed indoor radon values were lower. Seasonality and topography were not associated with indoor radon level. Understanding relationships among bedrock type, soil radon, and indoor radon exposure allows the development of practical predictive models that may support pre-construction forecasting of indoor radon potential based on geologic factors.

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Section: Introductionmentioning

confidence: 99%

Geologic, seasonal, and atmospheric predictors of indoor home radon values

Hahn

Haneberg

Stanifer

et al. 2023

Environ. Res.: Health

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“…3 Las partículas alfa emitidas por el radón pueden contribuir al riesgo de cáncer de piel melanoma y no melanoma y asma. 4,5 Igualmente, se ha asociado la exposición al radón residencial con cánceres no pulmonares, como los de piel, sistema nervioso central (SNC), renal y estómago. 6 El radón es un gas radiactivo que se encuentra naturalmente en el suelo y que puede acumularse en los edificios 4 .…”

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“…4,5 Igualmente, se ha asociado la exposición al radón residencial con cánceres no pulmonares, como los de piel, sistema nervioso central (SNC), renal y estómago. 6 El radón es un gas radiactivo que se encuentra naturalmente en el suelo y que puede acumularse en los edificios 4 . Es incoloro, inodoro e insípido 7 que resulta de la cadena de desintegración natural de los isótopos de uranio (uranio-238, uranio-236 y uranio-235) 8,9 , torio 10 y del radio-226 11 en el suelo, la roca, los materiales de construcción, las aguas subterráneas y las zonas mineras, y se puede encontrar en el entorno que nos rodea en concentraciones variables.…”

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La exposición al radón en las viviendas: ¿Un problema de salud pública? La necesidad de la implementación de un programa integral de vigilancia de radón

Ordoñez-Aquino¹,

Gonzales²

2023

spmi

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La Organización Mundial de la Salud (OMS) reconoce al radón como la segunda causa principal de cáncer de pulmón, en la población general, después del producido por el tabaquismo.1 Con un mayor riesgo de cáncer de pulmón para los fumadores debido a los efectos sinérgicos de los productos de descomposición del radón y el tabaquismo.2 También la exposición al radón ha sido asociada a leucemia infantil en pacientes que viven en Europa y áreas con altos niveles de radón (≥100 Bq/m3).3 Las partículas alfa emitidas por el radón pueden contribuir al riesgo de cáncer de piel melanoma y no melanoma y asma.4,5 Igualmente, se ha asociado la exposición al radón residencial con cánceres no pulmonares, como los de piel, sistema nervioso central (SNC), renal y estómago.

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Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census‐based cohort study

Coste,

Kreis,

Backes

et al. 2024

Intl Journal of Cancer

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Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0–15 years from the Swiss National Cohort during 1990–2016 and identified incident cancer cases through probabilistic record linkage with the Swiss Childhood Cancer Registry. We estimated the overall annual mean UV level and the mean level for the month of July during 2004–2018 at children's homes using a climatological model of the midday (11 am–3 pm) UV‐index (UVI) with a spatial resolution of 1.5–2 km. Using risk‐set sampling, we obtained a nested case–control data set matched by birth year and fitted conditional logistic regression models (virtually equivalent to analyzing full cohort data using proportional hazards models) adjusting for sex, neighborhood socio‐economic position, urbanization, air pollution, and background ionizing radiation. Our analyses included 1446 cases of CHM. Estimated adjusted hazard ratios (HR) per unit increase in UVI in July were 0.76 (95% CI 0.59–0.98) for leukemia and 0.74 (0.55–0.98) for ALL. Results for annual exposure were similar but confidence intervals were wider and included one. We found no evidence for an association for lymphoma overall (HR 1.14, 95% CI 0.59–2.19 for annual exposure) or diagnostic subgroups. Our study provides further support for an inverse association between exposure to ambient solar UVR and childhood ALL.

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A prospective cohort analysis of residential radon and UV exposures and malignant melanoma mortality in the Swiss population

Cited by 6 publications

References 33 publications

Geologic, seasonal, and atmospheric predictors of indoor home radon values

Geologic, seasonal, and atmospheric predictors of indoor home radon values

La exposición al radón en las viviendas: ¿Un problema de salud pública? La necesidad de la implementación de un programa integral de vigilancia de radón

Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census‐based cohort study

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