A prospective clinical and histologic study of axillary osmidrosis treated with the microwave-based device

Abstract

a b s t r a c tBackground: Microwave-based devices target sweat glands through energy delivery at the dermal esubcutaneous interface. These devices have been approved by the Food and Drug Administration as a noninvasive treatment for axillary hyperhidrosis. Treatment for osmidrosis has only been reported in one preliminary study. Objectives: To investigate the efficacy, safety, and histological changes of the microwave-based devices in treating axillary osmidrosis. Methods: We conducted a prospective study in a tertiary referral center in Taiwan. Patients with axillary osmidrosis were recruited and received two consecutive treatment sessions with a 3-month interval. Skin biopsy was obtained to evaluate histological changes. The efficacy was determined by odor reduction using a patient reported 10-point odor scale. Responders were defined as participants with a reduction of at least 3 points of the Odor-10 score at their 90-day follow-up visit. Results: Seven patients were enrolled. Mean reduction of odor was 61.8%. Six patients met the primary endpoint of odor reduction. Skin biopsy specimens reveled 93% reduction of apocrine glands. Histopathological changes include dermal fibrosis, necrosis of sweat glands, and subcutaneous fat necrosis. Transient swelling, bruise, numbness, lumps, and hypotrichosis were possible side effects. No patient reported disabling side effects. Conclusion: Microwave-based devices are noninvasive and a potential alternative therapeutic modality for axillary osmidrosis treatment.

Minimally invasive approaches to axillary osmidrosis treatment: A comparison between superficial liposuction with automatic shaver curettage, subcutaneous laser treatment, and microwave‐based therapy with a modified technique

“…In our study, we found that microwave‐based therapy was effective in treating osmidrosis with minimal downtime, recurrence, and complications. Its efficacy in treating hyperhidrosis has been reported by a randomized controlled trial; studies have also reported its efficacy in treating osmidrosis . The long‐term follow‐up observations in our study indicate that microwave‐based therapy could be a durable and effective therapeutic modality for osmidrosis and is less operator‐dependent.…”

“…This allowed for a higher level of microwave energy (level 5) to be applied, resulting in greater efficacy and preventing nerve injury . Furthermore, unlike conventional techniques reported in the literature, we carefully marked the alignment lines and treatment grids after tumescent anesthesia was infiltrated. If marking is performed before tumescent infiltration, tumescence‐induced skin distention, and line distortion may leave some areas untreated.…”

“…In contrast to previous studies, tumescent anesthesia was administered to our patients initially, followed by a careful marking with an oval template. The template was used to delineate the treatment zones (10 × 30 mm 2 ) with grids and handpiece alignment lines.…”

Removing the apocrine sweat glands with nasal endoscope assisted suction cutter: a new technique in the treatment of axillary odor

“…Malodor brings negative psychological, social and family effects to patients (1)(2). It is often difficult for the conservative treatment to achieve satisfactory effects, while surgical removal of sweat glands has a definite effect (3)(4)(5)(6)(7)(8)(9)(10)(11). At present, sweat gland resection surgery mainly includes removal under direct vision and blind pruning and trimming with small incision.…”

Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

“…However, for patients with blood coagulation disorders or undergoing surgery, dysfunctional coagulation causes bleeding or obstructive clotting 1 . Cryotherapy and radio frequency (RF) ablation are common solutions for therapy or vessel coagulation 2 3 4 5 6 . These treatment modalities induce a larger ablation area, resulting in extra damage to the surrounding tissue and difficulty with the treatment of specific areas or small vessels.…”