A prospective assessment of bowel habit in irritable bowel syndrome in women: Defining an alternator

Association Between SLC6A4 Serotonin Transporter Gene Lainked Polymorphic Region and ADRA2A −1291C>G and Irritable Bowel Syndrome in Korea

“…Although this entity were not well studied currently, some studies has reported IBS-M is more similar to IBS-C than IBS-D based on similarities in stool frequency, consistency, psychological symptoms and a higher likelihood of transition between these 2 subtypes longitudinally. 32,33 In the present study, it appears that clinical symptoms of IBS-M tend to more resemble IBS-C than IBS-D. Therefore, there might be a considerable movement from IBS-C to IBS-M, but despite several times' review of medical chart including history of medication such as laxative and antidiarrheal or longitudinal symptom change, 35 IBS-M patients in the present study could not be subclassified into either of IBS-D or IBS-C.…”

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

“…In IBS, there are also patients with alteration of bowel function (or mixed, IBS-M) which may be identified by symptoms (24); however, little is known about the pathophysiology of this subgroup. Autonomic dysfunction has been described in IBS patients (25)(26)(27), though the associations with motor and sensory dysfunctions in the same patients are unclear.…”

Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers

“…The division of IBS into different subgroups is based on the fact that these patients behave in dissimilar ways. According to the Rome Ⅱ criteria, building on stool and defecation patterns, IBS can be divided into diarrhoea predominant (D-IBS), constipation predominant (C-IBS) and alternating (A-IBS) subtypes [15,16] . Although, lately questioned, the Rome Ⅱ criteria are widely used in clinical practice [17] .…”