A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

Ishii, Kazusa; Birmann, Brenda M.; Zhang, Xuehong; Giovannucci, Edward; Bertrand, Kimberly A.

doi:10.3109/10428194.2015.1091928

Cited by 5 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We will compare the incidences and risk of outcomes in donors according to the frequency of donations and compare to the non‐donor population. There are limited number of studies examining the long‐term impact of whole blood donation on risk of cancers , cardiovascular diseases and plasma donation on risk of adverse bone health and the results reported from these studies are inconsistent. Thus, the EDV:Link study is in a strong position to contribute to long‐term donor health research by using comprehensive risk factor information in participants at baseline and follow‐up through the 45 and Up Study questionnaires and by following the cohort for health outcomes using data linkages with other healthcare data sets.…”

Section: Discussionmentioning

confidence: 99%

Demographic and health profile of older Australian blood donors: results from the Extended Donor Vigilance data linkage study (EDV:Link)

Gemelli

Thijsen

Karki

et al. 2018

ISBT Science Series

View full text Add to dashboard Cite

Background and Objectives Within Australia, there is a desire to increase blood donation frequency to meet the increasing demand for plasma and certain blood types. However, little is known about any long-term health consequences for donors. To address this gap, a data linkage study has been conducted, linking routine blood collection data to existing health outcome related data sources to create the Extended Donor Vigilance (EDV:Link) cohort. This paper describes the demographics and health characteristics of this cohort.Materials and Methods Australian Red Cross Blood Service data were linked to the Sax Institute's 45 and Up Study, to asses self-reported health risk behaviours, and the New South Wales Admitted Patients Database Collection (hospital records), to examine the hospitalization pattern. Participants were classified and described as current donors, lapsed donors and non-donors. ResultsOf the 266 885 participants in the 45 and Up Study, 25 231 (9Á5%) were identified as current donors and 12 452 (4Á7%) as lapsed donors. Compared to non-donors, current donors were younger, more highly educated, more likely to be in paid employment, more likely to be a non-smoker, consumed more alcohol and were more physically active. Compared to lapsed donors, current donors were younger, had fewer comorbidities and better self-reported health, consumed more alcohol and were more physically active.Conclusion Through the linkage of various health administrative data sets, the EDV:Link cohort provides rich information to answer important research questions relating to the sustainability of the Australian blood supply and long-term health outcomes of blood donors.

show abstract

Section: Discussionmentioning

confidence: 99%

Demographic and health profile of older Australian blood donors: results from the Extended Donor Vigilance data linkage study (EDV:Link)

Gemelli

Thijsen

Karki

et al. 2018

ISBT Science Series

View full text Add to dashboard Cite

show abstract

“…In general, the observed association between blood donation and long‐term health outcomes across the studies were inconsistent. Several studies showed blood donation has a protective effect on CVD, cancer, and death, 5–7,10,11,13,19,21,23,29 while other studies showed blood donation had no association with CVD, cancer, and death 9,12,15,17,18,21,24,25,31 . Some studies also found that apheresis donation was associated with reduction in bone mineral density (BMD) and increased risk of fracture, 16,28 while other studies found no association between blood donation and BMD markers 22,26,27,30 .…”

Section: Resultsmentioning

confidence: 99%

“…Several studies showed blood donation has a protective effect on CVD, cancer, and death, [5][6][7]10,11,13,19,21,23,29 while other studies showed blood donation had no association with CVD, cancer, and death. 9,12,15,17,18,21,24,25,31 Some studies also found that apheresis donation was associated with reduction in bone mineral density (BMD) and increased risk of fracture, 16,28 while other studies found no association between blood donation and BMD markers. 22,26,27,30 One of the studies reported that apheresis donors had an increased risk of bacterial infection.…”

Section: Main Outcomes Reported and Confounding Factors Consideredmentioning

confidence: 99%

A methods review of the “healthy donor effect” in studies of long‐term health outcomes in blood donors

2022

View full text Add to dashboard Cite

“…A large, randomized, controlled study of phlebotomy to maintain low‐normal iron levels in patients with symptomatic peripheral arterial disease did not find decreased mortality, myocardial infarction, or stroke . Blood donation has not been observed to provide a protective effect for cancer diagnosis . While increased ferritin levels are associated with diabetes and metabolic syndrome, pathophysiology and causation remain unclear.…”

Section: Potential Health Benefits Of Donating Bloodmentioning

confidence: 99%

Donor iron depletion: beneficial or burdensome?

Vassallo

2019

Transfusion

View full text Add to dashboard Cite

Most purported benefits of blood donation have not been proven. While studies suggest individuals with type II diabetes have transiently improved postdonation glycemic control, the mechanism is unknown.• Blood donors with nonanemic or mildly anemic iron deficiency can develop pica and undergo unnecessary diagnostic procedures. Lower infant birth weight has been documented in female blood donors. In other healthy populations, reversible fatigue and exercise capacity impairment occur with mild iron deficiency. The effects of donor iron depletion on cognition and neurocognitive outcomes after pregnancy continue to be studied.• Blood collectors are beginning to implement enhanced educational and interventional measures to prevent iron depletion in at-risk donors. D ata are slowly accumulating regarding the health benefits of blood donation and the potentially deleterious effects of donation-related iron deficiency with low-normal or mildly anemic hemoglobin (Hb) levels. Controversy exists regarding the need to intervene beyond simple donor education to reduce the burden of donation-related iron deficiency. POTENTIAL HEALTH BENEFITS OF DONATING BLOODEarly studies suggesting cardiovascular benefits of donation by depleting lipid-oxidizing iron were not sufficiently controlled for the healthy donor effect. As a group, blood donors have lower morbidity and mortality than the general population, potentially confounding research studies. Large cohort studies and a quasi-randomized study of disqualified donors failed to demonstrate any reduction in coronary disease or myocardial infarction. 1-3 A large, randomized, controlled study of phlebotomy to maintain low-normal iron levels in patients with symptomatic peripheral arterial disease did not find decreased mortality, myocardial infarction, or stroke. 4 Blood donation has not been observed to provide a protective effect for cancer diagnosis. 5-7 While increased ferritin levels are associated with diabetes and metabolic syndrome, pathophysiology and causation remain unclear. A number of small studies have suggested a glucose control benefit for phlebotomy, but at least one study of blood donors saw no improvement with high-versus low-frequency donation, a design eliminating the healthy donor effect but capable of missing a threshold benefit. 8,9 POTENTIAL DELETERIOUS EFFECTS OF IRON DEPLETIONThe multiple deleterious effects of severe iron deficiency anemia are undisputed. The effects of iron depletion to levels just below those required to sustain normal erythropoiesis, however, are not as clear. A recent AABB risk-based decision-making analysis estimated that up to 23% of presenting or successful donors have or develop donation-related iron deficiency anemia, while a similar number may have reduced but nonanemic Hb values. 10 The number of US at-risk donors is thus quite high. Donors lose approximately 250 mg of iron with whole blood donation and approximately 50 mg after giving apheresis platelets/plasma. Frequent donors can deplete their iron stores after only two or thr...

show abstract

A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

Cited by 5 publications

References 31 publications

Demographic and health profile of older Australian blood donors: results from the Extended Donor Vigilance data linkage study (EDV:Link)

Demographic and health profile of older Australian blood donors: results from the Extended Donor Vigilance data linkage study (EDV:Link)

A methods review of the “healthy donor effect” in studies of long‐term health outcomes in blood donors

Donor iron depletion: beneficial or burdensome?

Contact Info

Product

Resources

About