A proposed biparticle fluidized‐bed for lactic acid fermentation and simultaneous adsorption

Abstract

A bioreactor configuration is proposed for simultaneous fermentation and separation of the desired product. The bioreactor consists of a columnar fluidized bed of immobilized microorganisms. Denser adsorbent particles are added to this column. These adsorbent particles fall through the bed, absorb the product, and are removed from the base of the columnar reactor. The system hydrodynamics and the separability of the two types of particles were confirmed for low-density gel beads. The addition of the adsorbent, activated carbon, to a fermentation of Lactobacillus delbreuckii absorbed lactic acid. The addition of adsorbent enhanced the fermentation and controlled the pH.

Economic evaluation of an integrated process for lactic acid production from ultrafiltered whey

“…Some researchers have combined the fermentation operation with a separation step to simultaneously purify the lactic acid obtained. Ye, Jin, and Shimizu (1996) used multistage fermentation; Davidson and Scott (1992) combined fluidized bed fermentation with adsorption; Hane et al (1993) used solvent extraction for purification of the fermentation broths. Each of these research works have only studied single parts of the global process to obtain purified commercial lactic acid.…”

Recovery of lactic acid from simultaneous saccharification and fermentation media using anion exchange resins

“…However, comparatively high amounts of solvents are needed for extraction, and toxic effects are provoked by solvents [6,9]. In the electrodialysis units, cells adhered to membranes during the process, leading to decreased efficiency in the overall recovery system [8].…”

L(+)-Lactic acid recovery from cassava bagasse based fermented medium using anion exchange resins

“…However, comparatively high amounts of solvents are needed for extraction, and toxic effects are provoked by solvents. In the electrodialysis units, cells adhered to membranes during the process, leading to decreased efficiency in the overall recovery system (Nomura et al, 1987;Davison and Scott, 1992;Zihao and Kefeng, 1995;Moldes et al, 2003). Lactic acid from fermentation broth can be recovered using anion polymeric adsorbents, which were strong, moderate, or weak basic anion exchange resins adsorbing lactic acid below and above of its pKa (Moldes et al, 2003;Kulprathipanja and Oroshar, 1991).…”