A Proposal of The New Mechanism on Remnant Lipoprotein Formation and Clearance after Food Intake

Abstract

To understand the mechanism of plasma TG increase after food intake, the characteristics of remnant lipoproteins in postprandial plasma and the role of lipoprotein lipase (LPL) were investigated. The accumulation of TG in remnant lipoproteins (RLP-TG) is caused by the unchanged levels of LPL activity for hydrolysis of chylomicrons and VLDL when overloaded at endothelium after food intake. This review proposed a new hypothesis on the metabolism of plasma TG-rich lipoprotein based on the no-change of LPL activity at endothelium after food intake and the discovery of RLP-LPL complex in postprandial plasma.