2007
DOI: 10.1073/pnas.0601378104
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A proposal for robust temperature compensation of circadian rhythms

Abstract: The internal circadian rhythms of cells and organisms coordinate their physiological properties to the prevailing 24-h cycle of light and dark on earth. The mechanisms generating circadian rhythms have four defining characteristics: they oscillate endogenously with period close to 24 h, entrain to external signals, suffer phase shifts by aberrant pulses of light or temperature, and compensate for changes in temperature over a range of 10°C or more. Most theoretical descriptions of circadian rhythms propose tha… Show more

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Cited by 60 publications
(62 citation statements)
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“…In this case, while the temperature compensation effect may be a direct consequence of a requirement to uncouple short-term temperature fluctuations from cycle frequency, it may also be an indirect consequence of a more general requirement for the timing to be resistant to fluctuations in the kinetics of its underlying reactions due to, for example, small differences in gene expression levels. Thus, as with circadian rhythms, the temperature compensation in this age-state transition may be an indication of a robust timing mechanism that is not entirely dependent on a precise balance of underlying reaction rates (Hong et al 2007).…”
Section: Discussionmentioning
confidence: 98%
“…In this case, while the temperature compensation effect may be a direct consequence of a requirement to uncouple short-term temperature fluctuations from cycle frequency, it may also be an indirect consequence of a more general requirement for the timing to be resistant to fluctuations in the kinetics of its underlying reactions due to, for example, small differences in gene expression levels. Thus, as with circadian rhythms, the temperature compensation in this age-state transition may be an indication of a robust timing mechanism that is not entirely dependent on a precise balance of underlying reaction rates (Hong et al 2007).…”
Section: Discussionmentioning
confidence: 98%
“…Such solutions could be emulated to create synthetic gene circuits that are robust to a wide range of environmental perturbations. For instance, new insights into temperature compensation might be gained from circadian oscillators themselves (27,(43)(44)(45)(46)(47).…”
Section: Discussionmentioning
confidence: 99%
“…However, several hypotheses have emerged based on theoretical and experimental evidence (26,27). Hastings and Sweeney presented the simplest theoretical model for temperature compensation wherein opposing biochemical reactions form a feedback loop that maintains the pace of the clock (24).…”
mentioning
confidence: 99%
“…Although molecular and theoretical explanations for many aspects of circadian oscillators have been developed over the past decade [6], there have been few attempts to describe temperature compensation on a mathematical kinetic basis [26]. For an overview on other or related attempts to explain temperature compensation the reader is referred to the following papers [12,13,[15][16][17][18]27,28]. However, a discussion of these various approaches on how to "balance P" is beyond the scope of this paper.…”
Section: Discussionmentioning
confidence: 99%