A proposal for clinical trials of COVID-19 treatment using homo-harringtonine

Wen, Hai Jun; Liu, Feng-Liang; Huang, Ming; Luo, Rong; He, Wei; Feng, Jing; Chen, Fang Liang; Cai, Qi; Hua, Juan; Yang, Zhongping; Zhou, Xi; Shang, You; Lyu, Xue Mei; Zhang, Ding Yu; Xiao, Fei; Song, Hong; He, Jian; Zheng, Yong; Wu, Chung I.

doi:10.1093/nsr/nwaa257

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…2 shows that the IC50 is generally around 100 nM and the eradication is achieved at < 1uM. We note that these are the same range of values reported in the literature( 13, 33–37 ). In summary, eight different coronaviruses, including SARS-CoV-2, have been shown to be repressible by HHT at a comparable concentration.…”

Section: Introductionsupporting

confidence: 81%

“…(2020)( 41 ) which shows discrepancies with the literature in multiple drugs; see Wen et al . (2021)( 13 ) and Ianevski et al . (2020)( 37 )) As stated above, the specific mechanism of HHT repression of viral protein translation may be the key.…”

Section: Discussionmentioning

confidence: 94%

“…HHT is effective in repressing all 8 coronaviruses tested in vitro( 13, 33–37 ). The drug concentration necessary for viral clearance in vitro is consistently under 1 uM.…”

Section: Discussionmentioning

confidence: 99%

“…In this survey, we classify the studies by the life-cycle stage where the drug imposes its effects. The stages and publications are: attachment and entry( 5–9 ), translation of polyproteins( 10–13 ), proteolytic processing( 14, 15 ), transcription and replication( 16–18 )and multiple stages( 19, 20 ). It is generally accepted that comprehensive clinical benefits have not yet been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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Homo-harringtonine (HHT) – A highly effective drug against coronaviruses and the potential for large-scale clinical applications

Wen

Lin

et al. 2021

Preprint

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In the search for treatment schemes of COVID-19, we start by examining the general weakness of coronaviruses and then identify approved drugs attacking that weakness. The approach, if successful, should identify drugs with a specific mechanism that is at least as effective as the best drugs proposed and are ready for clinical trials. All coronaviruses translate their non-structural proteins (~16) in concatenation, resulting in a very large super-protein. Homo-harringtonine (HHT), which has been approved for the treatment of leukemia, blocks protein elongation very effectively. Hence, HHT can repress the replication of many coronaviruses at the nano-molar concentration. In two mouse models, HHT clears SARS-CoV-2 in 3 days, especially by nasal dripping of 40 ug per day. We also use dogs to confirm the safety of HHT delivered by nebulization. The nebulization scheme could be ready for large-scale applications at the onset of the next epidemics. For the current COVID-19, a clinical trial has been approved by the Ditan hospital of Beijing but could not be implemented for want of patients. The protocol is available to qualified medical facilities.

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Section: Introductionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 94%

“…HHT is effective in repressing all 8 coronaviruses tested in vitro( 13, 33–37 ). The drug concentration necessary for viral clearance in vitro is consistently under 1 uM.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Homo-harringtonine (HHT) – A highly effective drug against coronaviruses and the potential for large-scale clinical applications

Wen

Lin

et al. 2021

Preprint

Self Cite

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show abstract

“…The pandemic coronavirus disease 2019 (COVID-19) is caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By now, the number of scientific reports has been astounding, covering almost all aspects of COVID-19 [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [16] , [14] , [15] . Among the questions, the origin may be the most intriguing and controversial one.…”

Section: Introductionmentioning

confidence: 99%