A propensity score-matched comparison of the efficacies of OK-432 and talc slurry for pleurodesis for malignant pleural effusion induced by lung adenocarcinoma

Nohara, Kango; Takada, Kazuto; Kojima, Eiji; Ninomiya, Kiyoko; Miyamatsu, Shoko; Shimizu, Takahiro; Sakurai, Tsutomu; Mizuno, Tadahaya; Yamashita, Yuuki

doi:10.1016/j.resinv.2016.04.005

Cited by 9 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our work provides a previously unrealized opportunity in the utilization of GAS in the potential treatment of cancer. Discerning the capacity for GAS to form biofilms within CAF‐ and Saos‐2‐derived ECM, and the role of Scl1 in this process, is important since GAS has been under pre‐clinical (Linnebacher et al , ; Maletzki et al , ) and clinical (Yamaguchi et al , ; Roh and Park, ; Nohara et al , ; Wang et al , ) evaluation as a cancer therapeutic.…”

Section: Discussionmentioning

confidence: 99%

Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy

McNitt

Choi

Allen

et al. 2019

Molecular Microbiology

View full text Add to dashboard Cite

Summary The human‐adapted pathogen group A Streptococcus (GAS) utilizes wounds as portals of entry into host tissue, wherein surface adhesins interact with the extracellular matrix, enabling bacterial colonization. The streptococcal collagen‐like protein 1 (Scl1) is a major adhesin of GAS that selectively binds to two fibronectin type III (FnIII) repeats within cellular fibronectin, specifically the alternatively spliced extra domains A and B, and the FnIII repeats within tenascin‐C. Binding to FnIII repeats was mediated through conserved structural determinants present within the Scl1 globular domain and facilitated GAS adherence and biofilm formation. Isoforms of cellular fibronectin that contain extra domains A and B, as well as tenascin‐C, are present for several days in the wound extracellular matrix. Scl1‐FnIII binding is therefore an example of GAS adaptation to the host's wound environment. Similarly, cellular fibronectin isoforms and tenascin‐C are present in the tumor microenvironment. Consistent with this, FnIII repeats mediate GAS attachment to and enhancement of biofilm formation on matrices deposited by cancer‐associated fibroblasts and osteosarcoma cells. These data collectively support the premise for utilization of the Scl1‐FnIII interaction as a novel method of anti‐neoplastic targeting in the tumor microenvironment.

show abstract

Section: Discussionmentioning

confidence: 99%

Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy

McNitt

Choi

Allen

et al. 2019

Molecular Microbiology

View full text Add to dashboard Cite

show abstract

“…In general, pleurodesis using talc or OK-432 is considered effective in carcinomatous pleurisy when the lung is fully expanded by chest tube drainage [ 5 ]; however, it was not successful for pneumothorax and hemothorax in patient B. The mechanisms of pleural metastasis of SA are mentioned in the literature [ 1 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

Refractory pneumothorax and hemothorax associated with metastatic scalp angiosarcoma

et al. 2020

View full text Add to dashboard Cite

Background Pulmonary metastasis of scalp angiosarcoma (SA) is a rare, but life-threatening disease, challenging to diagnose and manage. We report two cases of pneumothorax and hemothorax with pathologically proven metastasis of SA in the parietal pleura, which was not predictable from images and difficult to manage. Patient A A 73-year-old man with SA underwent chemoradiotherapy and surgical resection for primary skin lesion, was sent to our department to treat right empyema, which was developed during chest tube drainage for pneumothorax. Computed tomography (CT) showed multiple bullous lesions. We performed repetitive video-assisted thoracoscopic surgery (VATS) for the debridement and hemostasis; however, hemothorax was uncontrollable. The repeated cytology of pleural effusion showed no malignancy. We eventually performed fenestration and metastatic SA was pathologically diagnosed by the biopsy of parietal pleura. The patient developed respiratory failure and uncontrolled anemia, which were fatal. Patient B A 71-year-old man with SA previously treated with chemoradiotherapy was referred to our department for left pneumothorax. CT showed multiple bullous lesions at apex without any changes at parietal pleura. VATS was performed and the apex bullous lesion with air leakage was resected. The parietal pleura showed several dark-red spots and the biopsy was undertaken. The pathological diagnosis was a metastasis of SA along with visceral pleura and parietal pleura. The patient then developed right pneumothorax and left hemopneumothorax. Bilateral pleurodesis was ineffective and the patient died due to deteriorating general condition. Conclusions In patients with a history of SA who develop pneumothorax and hemothorax, metastatic SA to visceral and parietal pleura should be always considered. Surgical biopsy, not cytology, is needed for pathological diagnosis. Lesions in the parietal pleura prior to hemothorax were thoracoscopically observed in one case. Surgeons must recognize that conventional surgical intervention or pleurodesis will have unsatisfactory results.

show abstract

“…Meta-analysis of their results shows a mean difference of -835 ml (95% CI -1437 --234, p=0.006, I 2 45.9%, p=0.174) between the volume of effusion drained in the success and the failure groups respectively (figure 3B). Nohara et al [38] performed a multivariate logistic regression analysis of factors associated with pleurodesis success and found an OR of 0.995 (95% CI 0.992-0.998, p <0.001) for volume of drainage in mls.…”

Section: Volume Of Fluid Drained Pre-pleurodesismentioning

confidence: 99%

Predictors of outcome of pleurodesis in patients with malignant pleural effusion: a systematic review and meta-analysis

Hassan

Gadallah

Mercer

et al. 2020

Expert Review of Respiratory Medicine

View full text Add to dashboard Cite

Objectives: Pleurodesis is an important management option to palliate breathlessness in patients with malignant pleural effusion (MPE). This systematic review aimed to examine available literature for studies investigating factors that predict pleurodesis outcome.Methods: the healthcare databases advanced search (HDAS) Medline and Embase in addition to Cochrane Database of Systematic Reviews were searched on for publications reporting on pleurodesis for MPE in English language. All studies types reporting previously unpublished data on predictors of pleurodesis success were included. 34 studies involving 4626 patients were included in the systematic review. The most common pleurodesis agent used was talc which was used in 27 studies. Meta-analyses demonstrated that the strongest predictors of pleurodesis success were higher pleural fluid pH, smaller volume of effusion pre-pleurodesis and full lung re-expansion post effusion drainage. Shorter duration of tube drainage, higher pleural fluid glucose, lower LDH and lower pleural tumour burden all seem to favour pleurodesis success, but with considerable statistical heterogeneity between studies. Available data do not suggest that chest tube size affects pleurodesis outcome. Conclusion:Overall, available results are difficult to interpret due to evidence quality.Prospective studies are needed to further explore these factors.

show abstract

A propensity score-matched comparison of the efficacies of OK-432 and talc slurry for pleurodesis for malignant pleural effusion induced by lung adenocarcinoma

Cited by 9 publications

References 23 publications

Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy

Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy

Refractory pneumothorax and hemothorax associated with metastatic scalp angiosarcoma

Predictors of outcome of pleurodesis in patients with malignant pleural effusion: a systematic review and meta-analysis

Contact Info

Product

Resources

About