A propensity-matched comparison of survival after lung resection in patients with a high versus low body mass index

Abstract

Unlike in breast cancer, a high BMI in lung cancer patients after resection has protective effects. This may be due to the better nutritional status of the patient, a less aggressive cancer type that has not resulted in weight loss at the time of presentation or it may be due to certain hormones released from the adipose tissue. BMI can be a predictor of outcome after lung resection in cancer patients.

The Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non–Small Cell Lung Cancer

“…Similar to our study, authors observed significantly improved OS in patients with BMI ≥30, as compared to patients with BMI<30. 5 …”

“…4 One other study of 337 patients focused on long-term outcomes based on BMI in surgically resected lung cancer and found high BMI to have a protective effect. 5 Recently, a meta-analysis of 25 surgical observational studies concluded that “obesity paradox” has a potential to exist in lung cancer surgery; this statement was based on the results, which demonstrated that obesity had favorable effect on both in-hospital outcomes as well as long-term survival of surgical patients with lung cancer…”

Wedge resection verses lobectomy for stage 1 non-small-cell lung cancer

“…Subanalysis by age, BMI, and utilization of PET scanning is shown in Figure 1(b)-(G). [6][7][8] Cox regression analysis confirmed that age (p < 0.0001), BMI (p ¼ 0.0016), female sex (p < 0.0001), being a current smoker (p ¼ 0.0019), tumor diameter (p ¼ 0.01), and preoperative forced expiratory volume in 1 s (p < 0.0001) were significant factors determining long-term survival ( Table 2). Resection margin length, histology subtype (adenocarcinoma or squamous cell), PET scanning, being a non-smoker, and wedge or lobectomy resections were excluded by the stepwise regression model.…”

Pneumonectomy: risk factor or innocent bystander?

“…11 Squamous and adenocarcinoma have different distributions with regard to site of occurrence in the bronchial tree. 12 This will affect the stage and procedure performed. After multivariate analysis, histological type did affect long-term survival, but pneumonectomy was still not a significant factor determining long-term survival.…”