A proof-of-concept randomized phase 2 non-inferiority trial on simple versus modified radical hysterectomy in IA2-IB1 cervical cancer ≤2cm (LESSER)

Carneiro, Vandré Cabral Gomes; Batista, Thales Paulo; Andrade, Manoel Rodrigues; Barros, Aldo Vieira; Bezerra, Artur Lício Rocha; Camara, L de Olanda Lima Dornelas; Ramalho, Nathalia Moreira; Lucena, M Angelica; Fontao, Diogenes; Tancredi, Rodrigo; Júnior, Tyrone César Silva; Baiocchi, Glauco

doi:10.1016/s0090-8258(21)00714-9

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Rationale For Conservative Surgery1

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2023

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“…Preliminary data presented as an oral abstract at SGO 2021 showed similar quality of life measures and post-operative complications but greater length of surgery in the radical hysterectomy arm. Survival outcomes have not yet been reported [46]. The SHAPE trial (NCT01658930) and GOG 278 (NCT01649089) are both still active trials that have not yet reported outcomes.…”

Section: Rationale For Conservative Surgerymentioning

confidence: 99%

A Case for the Conservative Management of Stage IA Cervical Cancer

Blackman,

Creasman

2023

Cancers

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Cervical cancer remains a significant public health concern within the United States and across the world. Cervical cancer is most frequently diagnosed in women between the ages of 35 and 44 and therefore affects a younger patient population than many other cancers. The management of early-stage disease has frequently utilized radical hysterectomy with the associated increased surgical morbidity, without clear evidence of any benefits. In stage IA disease, there are retrospective pathologic data supporting the safety of conservative surgery and lymphadenectomy over radical hysterectomy. There are also emerging prospective studies supporting conservative management. This editorial presents the evidence for conservative management of stage IA cervical cancer by reviewing the existing retrospective studies as well as the ongoing prospective studies.

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Section: Rationale For Conservative Surgerymentioning

confidence: 99%