A promoter polymorphism of MSTN g.−371T&gt;A and its associations with carcass traits in Korean cattle

Han, Sang‐Hyun; Cho, In-Cheol; Ko, Moon-Suck; Kim, Eun Young; Park, Se-Pill; Lee, Sung-Soo; Oh, Hong Shik

doi:10.1007/s11033-011-1153-z

Cited by 30 publications

(23 citation statements)

References 37 publications

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“…Results of the present studies support those obtained by other authors who demonstrated that the A allele frequency was low in a number of analysed cattle breeds [12].…”

Section: Itemsupporting

confidence: 92%

Polymorphisms of the CAPN1, CAST and MSTN Genes, and Their Association with Histological and Textural Parameters of Beef from Polish Holstein-Friesian Cattle

Węglarz¹,

Balakowska²,

Kułaj³

2019

JAST-A

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The purpose of this study was to analyse polymorphisms of the CAPN1, CAST and MSTN genes and their association with the microstructure of the Musculus longissimus thoracis (MLT) and textural parameters in bulls of the Holstein-Friesian breeds, black-and-white variety. The polymorphisms at the three loci: in position 6536 of the 3'UTR region of the CAPN1 gene, in position 230 of intron 5 in CAST gene, and in position 371 of the promoter region of the MSTN gene were analysed. Given the inconsequential genetic diversity at the analysed CAPN1 and MSTN loci in the animal sample, it was considered unreasonable to perform further statistical analyses aimed at determining associations between polymorphisms in these positions and meat characteristics. Based on an analysis of the CAST gene polymorphism, a significant association with certain histological and textural parameters was identified.

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“…Results of the present studies support those obtained by other authors who demonstrated that the A allele frequency was low in a number of analysed cattle breeds [12].…”

Section: Itemsupporting

confidence: 92%

Polymorphisms of the CAPN1, CAST and MSTN Genes, and Their Association with Histological and Textural Parameters of Beef from Polish Holstein-Friesian Cattle

Węglarz¹,

Balakowska²,

Kułaj³

2019

JAST-A

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“…Polymorphisms in the MSTN gene have been correlated to production traits, making it a candidate target gene to enhance livestock and fowl productivity (Lu et al, 2011;Han et al, 2012 andZhang et al, 2012). However, in many cases, the allele associated with favourable production traits is not always favourable for reproductive traits.…”

Section: Introductionmentioning

confidence: 99%

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

2016

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The Myostatin (MSTN), or Growth and Differentiation Factor 8 (GDF8), gene has been implicated in the double muscling phenomenon, in which a series of mutations render the gene inactive and unable to properly regulate muscle fibre deposition. Single nucleotide polymorphisms (SNPs) in the MSTN gene have been correlated to production traits, making it a candidate target gene to enhance livestock and fowl productivity. This study aimed to assess any association of three SNPs in the rabbit MSTN gene (c.713T>A in exon 2, c.747+34C>T in intron 2, and c.*194A>G in 3'-untranslated region) and their combinations, with carcass, production and reproductive traits. The investigated traits included individual body weight, daily body weight gain, carcass traits and reproductive traits. The 3 SNPs were screened using PCR-restriction fragment length polymorphism (RFLP)-based analysis and the effects of the different SNP genotypes and their combinations were estimated in a rabbit population. Additionally, additive and dominance effects were estimated for significant traits. The results found no significant association between the c.713 T>A SNP and all the examined traits. Allele T at the c.747+34C>T SNP was only significantly associated (P<0.05) with increased body weight at 12 wk of age. However, for the SNP residing in the 3' untranslated region (c.*194A>G), allele G was significantly associated (P<0.05) with increased body weight and high growth rate. Genotype GG at the c.*194A>G SNP also had positive effects on most carcass traits. The estimated additive genetic effect for the c.*194A>G SNP was significant (P<0.05) with most body weight, daily gain and carcass traits. No significant association was obtained between any MSTN SNPs and reproductive traits. In the combinations analysis, regardless of the genotypes of SNPs at c.713T>A and c.747+34C>T, GG at the c.*194A>G SNP correlated with highest values in body weight and daily weight gain. In conclusion, the 'G' allele at the c.*194A>G SNP had positive effects on growth and carcass traits and so could be used as a favourable allele in planning rabbit selection. Further population-wide studies are necessary to test the association of the c.*194A>G SNP with carcass traits. We also recommend evaluation of the potential effects of the c.*194A>G SNP on MSTN gene expression.

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“…Nasr et al, (2016) reported that allele and gene frequencies were homozygot for MSTN gene in Holstein bull (AA). Han et al (2012) investigated that the relationship between MSTN g.-371T>A gene and carcass characteristics in Korean cattle. For this purpose, three different genotypes using DraI restriction enzymes have identified in Holstein, Juju Black Cattle and Hanwoo breeds.…”

Section: Resultsmentioning

confidence: 99%

Molecular Characterization of MSTN Gene in Holstein Friesians and Brown Swiss Cattle Breeds

Fadhil¹,

Zülkadir²

2017

SJAFS

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A promoter polymorphism of MSTN g.−371T>A and its associations with carcass traits in Korean cattle

Cited by 30 publications

References 37 publications

Polymorphisms of the CAPN1, CAST and MSTN Genes, and Their Association with Histological and Textural Parameters of Beef from Polish Holstein-Friesian Cattle

Polymorphisms of the CAPN1, CAST and MSTN Genes, and Their Association with Histological and Textural Parameters of Beef from Polish Holstein-Friesian Cattle

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

Molecular Characterization of MSTN Gene in Holstein Friesians and Brown Swiss Cattle Breeds

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