A promoted copper-catalysed Azide-alkyne cycloaddition (CuAAC) for broad spectrum peptide-engineered implants

Hu, Guoqing; Chen, Junjian; Fan, Yan; Zhou, Haiyan; Guo, Kunzhong; Fang, Zhou; Xie, Liangxu; Wang, Lin; Wang, Yingjun

doi:10.1016/j.cej.2021.130918

Cited by 10 publications

(5 citation statements)

References 44 publications

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“…In Fig. 1a and b, since it was first proposed to use copper( i ) as a transition metal catalyst for 1,3-dipolar cycloaddition between terminal alkynes and azides to synthesize [1,2,3]-triazole in mild environments, 12,42 CuAAC served as an ideal complement to the click reaction family and facilitated the development of TMC-based bioorthogonal chemistry in biomedical applications such as in situ synthesis of drugs, 29 disease therapy, 43 bioengineering, 44 etc . A universal feature of these various applications relying on the CuAAC reaction is that the investigators usually employ different approaches to avoid the most worrying drawbacks of the CuAAC reaction, that is, the instability and toxicity of Cu( i ) catalysts in vivo .…”

Section: A Brief Historical Overview Of Tmcs For Bioorthogonal Chemistrymentioning

confidence: 99%

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Bioorthogonal nanozymes: an emerging strategy for disease therapy

Zhang,

Fan

2023

Nanoscale

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Section: A Brief Historical Overview Of Tmcs For Bioorthogonal Chemistrymentioning

confidence: 99%

“…Moreover, the fabricated peptide-engineered implants not only demonstrated superior advantages in inhibiting five types of clinical bacteria in vitro , but also promoted angiogenesis and osteogenesis in vivo , rendering CuAAC reactions more clinically valuable. 44…”

Section: A Brief Historical Overview Of Tmcs For Bioorthogonal Chemistrymentioning

confidence: 99%

Bioorthogonal nanozymes: an emerging strategy for disease therapy

Zhang,

Fan

2023

Nanoscale

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“…Further, although it is very effective to apply click reactions to design new biological macromolecules, [5,21,22] separations of generally toxic residual copper after the reaction is often challenging. [23] Thus, the trace of copper ions that remain after the click reaction can introduce cytotoxicity to the cells, hindering the practical usage of click reaction in tissue engineering or medicinal applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Catalytic Studies of Thermoresponsive Copper (I) Complex towards Click Reactions

et al. 2023

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Click reaction or copper‐assisted azide–alkyne cycloaddition (CuAAC) reaction can conveniently synthesize desired organic molecules or functionalize biological macromolecules. In many cases, trace amounts of residual copper from the reaction mixture are not trivial to remove when the exhaustive purification step is avoided to fulfill the essential criteria of a click reaction. It is often detrimental, particularly for biochemical applications or when it involves biological macromolecules. Herein, we have reported the synthesis of a new type of copper (I) complex as a smart catalyst for click reaction, which can be separated from the reaction mixture very easily by the slight elevation of temperature, thanks to its thermoresponsive behavior. The click reactions using a thermoresponsive catalyst were first studied in an aqueous medium using various organic molecules containing alkyne and azide functional groups. Later, the strategy was extended to biological macromolecules like collagen.

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“…Metal nanoclusters (MNCs) consisting of a few to tens of metal atoms possess remarkably and inherently physical, electrical, and optical properties. , Particularly, CuNCs are superior for the easy, eco-friendly, and cost-effective synthesis when compared to other luminescent metals, such as AuNCs and AgNCs. Thus, they have been extensively applied in the field of sensing, imaging, catalyzing, and electronic devices. − Unfortunately, the development of CuNCs is usually constrained by the unsatisfactory stability and low fluorescence as a result of their high surface energy and easy oxidation of Cu . Extensive efforts have been devoted to improve the fluorescence properties of CuNCs, including fabrication of alloy NCs, aggregation-induced emission (AIE), , confinement effect, − etc.…”

Section: Introductionmentioning

confidence: 99%

Anchoring Cu Nanoclusters on Melamine–Formaldehyde Microspheres: A New Strategy for Triggering Aggregation-Induced Emission toward Specific Enzyme-Free Methyl Parathion Sensing

Huang

et al. 2022

J. Agric. Food Chem.

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Methyl parathion (MP) residues have aroused extensive attention on account of their significant threat to the environment and food safety. Currently reported fluorescent methods used for MP sensing largely depend upon an enzyme. Designing a facile and specific enzyme-free MP fluorescent sensor is in great demand, which remains a challenge. Here, negatively charged Cu nanoclusters (CuNCs) anchored on positively charged melamine–formaldehyde (MF) microspheres (MF@CuNCs) through an electrostatic interaction were prepared. MF microspheres triggered aggregation-induced emission (AIE) of CuNCs and successfully circumvented the shortcomings of poor stability and low luminescence of CuNCs. The fluorescence intensity of MF@CuNCs can be quenched by p-nitrophenol produced by MP under alkaline conditions. Accordingly, a specific enzyme-free MP sensing method was constructed with MF@CuNCs. In combination with a smartphone, visually quantitative analysis of MP in a fast and portable way was also achieved. For the first time, AIE of CuNCs used for enzyme-free MP sensing was successfully explored in this work, and it is believed that this method will open a new pathway for AIE of CuNCs to be applied in various applications.

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A promoted copper-catalysed Azide-alkyne cycloaddition (CuAAC) for broad spectrum peptide-engineered implants

Cited by 10 publications

References 44 publications

Bioorthogonal nanozymes: an emerging strategy for disease therapy

Bioorthogonal nanozymes: an emerging strategy for disease therapy

Synthesis and Catalytic Studies of Thermoresponsive Copper (I) Complex towards Click Reactions

Anchoring Cu Nanoclusters on Melamine–Formaldehyde Microspheres: A New Strategy for Triggering Aggregation-Induced Emission toward Specific Enzyme-Free Methyl Parathion Sensing

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