A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic
            <i>Serratia marcescens</i>

Shi, Ping; Praphakar, Rajendran Amarnath; Deepa, S.; Kannan, Suganya; Gupta, Prashant; Ullah, Riaz; Bari, Ahmed; Murugan, Marudhamuthu; Rajan, Mariappan

doi:10.1080/10717544.2020.1809557

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…AuNPs were prepared by the citric acid reduction method [28] , [29] , [30] , [31] . In short, 5 ml fresh trisodium citrate solution (1%, w/v) was added to 95 ml boiled auric acid solution (0.01%, w/v).…”

Section: Methodsmentioning

confidence: 99%

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Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

Duan

et al. 2021

Asian Journal of Pharmaceutical Sciences

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There is growing empirical evidence that certain types of chemotherapy and phototherapy trigger immunogenic cell death and enhance the therapeutic anticancer efficacy of genetic immunotherapy. However, the main challenge is spatiotemporally co-delivering different drugs to maximize the therapeutic index of the combination therapy. In this study, a drug delivery system (HTCP-Au/shPD-L1/DOX) was designed with a polysaccharide-wrapped shell and a condensed DNA core. To construct the HTCP-Au vector, dodecyl side chains with a polyethylenimine (PEI) head were grafted onto hyaluronic acid, and AuNPs were grafted via Au-S bonds. During drug loading, PEI arrested shRNA plasmid DNA targeting programmed cell death ligand 1 (shPD-L1) via electrostatic interactions. It also formed a PEI-DNA core that was automatically enclosed when aliphatic hydrocarbons pulled the hyaluronic acid backbone. A hydrophobic interlayer consisting of dodecyl bridge chains between the PEI-DNA core and the hyaluronic acid shell was required to accommodate hydrophobic doxorubicin. In vitro and in vivo assays demonstrated that this core-shell drug delivery system could efficiently load and transport three different drugs and effectively target tumors. Moreover, it could activate the immune system, thereby providing promising therapeutic efficacy against tumor growth and metastasis.

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Section: Methodsmentioning

confidence: 99%

“…As previously reported [31] , [32] , [33] , HTCP (0.5000 g) was dissolved in 90 mL ultrapure water, and 90 ml AuNP solution was added dropwise under nitrogen protection. The mixture was stirred in the dark for 24 h and then centrifuged at 1.2 × 10 4 r/min for 20 min.…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

Duan

et al. 2021

Asian Journal of Pharmaceutical Sciences

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“…Serratia marcescens is also a pathogen for urinary tract infections and nosocomial infections. A polymer‐based system (AuNPs/RF/INH/CS‐g‐PMDA‐CYS system) to deliver drugs against nosocomial S. marcescens reduced bacterial drug resistance by inhibiting swarming motility and prodigiosin pigment production, and improved the survival of Caenorhabditis elegans by inhibiting biofilm and virulence 186 …”

Section: Applications Of Nanomaterials In Different Infectious Diseasesmentioning

confidence: 99%

“…Chitosan-g-PMDA-CYS conjugated to AuNPs Controlled drug release, reduced drug resistance [186] Diagnosis / E. coli PAC-polyaniline NCs Sensitive, reproducible, stable and specific detection [187] / P. aeruginosa ZnO-Cys Detect P. aeruginosa by AHLs, have high sensitivity [188] / / AuNPs Rapid and accurate identification [189] Gastrointestinal infections…”

Section: E Colimentioning

confidence: 99%

“…A polymer-based system (AuNPs/RF/INH/ CS-g-PMDA-CYS system) to deliver drugs against nosocomial S. marcescens reduced bacterial drug resistance by inhibiting swarming motility and prodigiosin pigment production, and improved the survival of Caenorhabditis elegans by inhibiting biofilm and virulence. 186 Diagnosis of urethral pathogens, such as urine culture, is time-consuming and laborious, while alternative strategies, such as PCR and ELISA, need professional persons and instruments. As a result, researchers made nanobiosensors that specifically detect E. coli through the agglutination reaction of cranberry proanthocyanidins 206 and tailored E. coli receptors.…”

Section: Urinary Tract Infectionsmentioning

confidence: 99%

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Applications of nanomaterials as treatments and diagnostic biosensors in microbial infections

Zou,

Tao,

et al. 2023

MedComm – Biomaterials and Applications

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Microbial infection is a major medical problem that seriously threatens public health. The abuse of antibiotics that help evolve the emergence of new drug‐resistance mechanisms has led to the wide‐spread and fast expansion of drug‐resistant bacteria, ultimately evolving into superbugs. This significantly impairs the timely and effective treatment of infections, thus threatening global human well‐being. Not all are pessimistic. Nanomaterials have emerged as an innovative choice. Due to their unique physical and chemical properties, superior bactericidal effects, and high biocompatibility, nanomaterials may help eradicate drug‐resistant bacteria to achieve complete remission of infectious diseases. As biological materials, nanomaterials can also improve the efficacy of existing drugs and treatments and even facilitate diagnostic efficiency. In this review, we aim to comprehensively summarize the antibacterial properties of different kinds of nanomaterials and their applications in other spheres related to treating infectious diseases (targeted therapy, phototherapy, vaccine development, and microbial diagnosis). We highlight the latest advances of nanomaterials in treating infectious diseases in different body systems. Finally, we conclude by discussing the weaknesses of currently available materials and unresolved scientific problems, which may provide insights into the development of approved agents that adequately overcome the notorious drug resistance and thereby provide unprecedented discoveries to improve treatments of the most severe bacterial infections.

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Gold nanoparticles for treatment of infectious diseases

Vieira,

Tessaro,

Conte-Junior

2024

Gold Nanoparticles for Drug Delivery

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A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic Serratia marcescens

Abstract: Rajan (2020) A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for inhibition of multidrug-resistant uropathogenic

Cited by 10 publications

References 34 publications

Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

Applications of nanomaterials as treatments and diagnostic biosensors in microbial infections

Gold nanoparticles for treatment of infectious diseases

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