A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

Kim, Min Woo; Kwon, Seung‐Hae; Choi, Jung Hoon; Lee, Ruda

doi:10.3390/ijms19123859

Cited by 47 publications

(26 citation statements)

References 152 publications

(150 reference statements)

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“…Light-responsive biological (bioinspired) drug carriers can be considered as one of the most attractive delivery systems, replicating features that are similar to the biological objects [212]. The main advantages of bioinspired carriers are their ability to interact with specific sites of the body, their cell/tissue entering mechanisms, capability to avoid the immune responses, and prolonged circulation times in biological fluids [212,213]. Light-responsive bioinspired carriers include the use of (4.…”

Section: Composite Light-sensitive Bioinspired Delivery Platformsmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

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Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

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Section: Composite Light-sensitive Bioinspired Delivery Platformsmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

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“…According to Kurien et al (2007), the solubility of curcumin in water could be maximized by dissolving first in methanol and then diluting with water or even using heat. Furthermore, the use of the cell membrane can improve the bioavailability of curcumin using lipid-based nanoparticles that capture hydrophobic drugs, and also allow intravenous injection (Kim et al, 2018). We also showed that curcumin has additional therapeutic benefits by using R/P-cGNS for cancer therapies including photothermal effects, controlled drug release at elevated temperature, and the targeting of cancer cells through PLTs.…”

Section: Discussionmentioning

confidence: 77%

Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions

Kim

Lee

Niidome

et al. 2020

Front. Bioeng. Biotechnol.

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The cell membrane-coating strategy has opened new opportunities for the development of biomimetic and multifunctional drug delivery platforms. Recently, a variety of gold nanoparticles, which can combine with blood cell membranes, have been shown to provide an effective approach for cancer therapy. Meanwhile, this class of hybrid nanostructures can deceive the immunological system to exhibit synergistic therapeutic effects. Here, we synthesized red blood cell (RBC) and platelet membrane-coated gold nanostars containing curcumin (R/P-cGNS) and evaluated whether R/P-cGNS had improved anticancer efficacy. We also validated a controlled release profile under near-infrared irradiation for the ability to target melanoma cells and to have an immunomodulatory effect on macrophages. RBC membrane coating provided selfantigens; therefore, it could evade clearance by macrophages, while platelet membrane coating provided targetability to cancer cells. Additionally, the nutraceutical curcumin provided anticancer and anti-inflammatory effects. In conclusion, the results presented in this study demonstrated that R/P-cGNS can deliver drugs to the target region and enhance anticancer effects while avoiding macrophage phagocytosis. We believe that R/P-cGNS can be a new design of the cell-based hybrid system for effective cancer therapy.

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“…Therefore, the specific emphasis should be given to the toxicity of the blank nanoparticles (non-drug loaded particles) 44. Generally, lipid nanoparticles are considered biocompatible,46 and our in-vitro cytotoxicity study of blank NLC demonstrated that no significant toxicity. However, since there are a variety of cells affected by nanoparticle exposure in the different route of administration, cytotoxicity assays using single-cell studies is not sufficient 47.…”

Section: Discussionmentioning

confidence: 91%

<p>Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer</p>

Kebebe¹,

Wu²,

Zhang³

et al. 2019

IJN

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Background and purpose: Gambogic acid (GA) is a natural compound that exhibited a promising multi-target antitumor activity against several types of cancer. However, the clinical application of this drug is limited due to its poor solubility and low tumor cell-specific delivery. In this study, the monomeric and dimeric Cyclo (Arg-Gly-Asp) c(RGD) tumor targeting peptides (c(RGDfK) and E-[c(RGDfK) 2 ]) were used to modify GA loaded nanostructured lipid carriers (NLC) to reduce the limitations associated with GA and improve its antitumor activity. Methods: GA-NLC was prepared by emulsification and solvent evaporation methods and the surface of the NLC was conjugated with the c(RGD) peptides via an amide bond. The formulations were characterized for particle size, morphology and zeta potential, encapsulation efficiency and drug loading. The in-vitro cytotoxicity and cell uptake studies were conducted using 4T1 cell. Furthermore, the in-vivo antitumor activity and bio-distribution study were performed on female BALB/c nude mice. Results: The c(RGD) peptides modified GA-NLC was successfully prepared with the particles size about 20 nm. The HPLC analysis, FT-IR and 1 H-NMR spectra confirmed the successful conjugation of the peptides with the NLC. The in-vitro cytotoxicity study on 4T1 cells revealed that c(RGD) peptides modified GA-NLCs showed significantly higher cytotoxicity at 0.25 and 0.5 µg/mL as compared to unmodified GA-NLC. Furthermore, the cell uptake study demonstrated that better accumulation of E-[c(RGDfK) 2 ] peptides modified NLC in 4T1 cell after 12 h incubation. Moreover, the in-vivo study showed that c(RGD)s functionalized GA-NLC exhibited better accumulation in tumor tissue and tumor growth inhibition. In contrast to the monomeric c(RGD) peptide, the dimeric c(RGD) peptide (E-[c(RGDfK) 2 ]) conjugated GA-NLC showed the improved antitumor activity and tumor targeting ability of GA-NLC. Conclusion: These data provide further support for the potential clinical applications of E-[c(RGDfK) 2 ]-GA-NLC in breast cancer therapy.

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A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

Cited by 47 publications

References 152 publications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions

<p>Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer</p>

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