A Promising Approach Toward Exploring Nutritional and Functional Qualities of Beko (<i>O</i>
                        <i>roxylum Indicum</i>
 L. Benth. Ex Kurz) Pods For Potential Food Applications

Bhat, Rajeev; Shaharuddin, Nursyarfa Ayuni; Kuang, Yeoh Tow

doi:10.1111/jfpp.12207

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…Oroxylum indicum (L.) Kurz is a species of flowering plant belonging to the Bignoniaceae family. Fruit pods of this plant have been used in many Asian countries as a plantbased food and herbal medicine for thousands of years without any known adverse effects [7][8][9]. Numerous scientific studies showed that O. indicum was not toxic even in experimental animals, even up to high doses [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous scientific studies showed that O. indicum was not toxic even in experimental animals, even up to high doses [10][11][12]. e fruit pods of this plant are rich in nutrients concerning dietary fiber, essential amino acids, minerals, and fatty acids [8]. Every part of this tree is also an essential source of several medicinally essential flavonoids, including baicalein, chrysin, and oroxylin A, which have contributed to many of the biological activities.…”

Section: Introductionmentioning

confidence: 99%

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Intracellular ROS Scavenging and Anti‐Inflammatory Activities of Oroxylum indicum Kurz (L.) Extract in LPS plus IFN‐γ‐Activated RAW264.7 Macrophages

Dunkhunthod

Talabnin

Murphy

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Oroxylum indicum (L.) Kurz has been used as plant-based food and herbal medicine in many Asian countries. The aim of the present study was to examine the antioxidant and anti-inflammatory activities of O. indicum extract (O. indicum) in RAW264.7 cells activated by LPS plus IFN-γ. The phytochemical compounds in O. indicum were identified by GC-MS and LC-MS/MS. Five flavonoids (luteolin, apigenin, baicalein, oroxylin A, and quercetin) and 27 volatile compounds were found in O. indicum. O. indicum presented antioxidant activities, including reducing ability by FRAP assay and free radical scavenging activity by DPPH assay. Moreover, O. indicum also suppressed LPS plus IFN-γ-activated reactive oxygen species generation in RAW264.7 macrophages. It possessed the potent anti-inflammatory action through suppressing nitric oxide (NO) and IL-6 secretion, possibly due to its ability to scavenge intracellular ROS. The synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy results showed the alteration of signal intensity and integrated areas relating to lipid and protein of the activated RAW264.7 macrophages compared to unactivated cells. This is the first report of an application of the SR-FTIR technique to evaluate biomolecular changes in activated RAW264.7 cells. Our results indicate that O. indicum may be used as a potential source of nutraceutical for the development of health food supplement or a novel anti-inflammatory herbal medicine.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intracellular ROS Scavenging and Anti‐Inflammatory Activities of Oroxylum indicum Kurz (L.) Extract in LPS plus IFN‐γ‐Activated RAW264.7 Macrophages

Dunkhunthod

Talabnin

Murphy

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Leaves were claimed for antioxidant activities, antiviral activities, especially chikungunya, and reduction of oxidative stress [13][14][15][16]. Young leaves, fruits, pods, and unripe seeds are edible and contained crude protein, ash, crude fiber, carbohydrates, amines, amides, carboxylic acids, and aromatic compounds [17]. Leaves contained important flavonoids, namely, chrysin, baicalein, baicalein-7-O-glucoside, baicalein-7-O-diglucoside, chrysin-7-O-glucuronide, baicalein-7-O-glucuronide, and a chrysin-diglucoside [18].…”

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Begum

Islam

Begum

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The stem bark of Oroxylum indicum (O. indicum) was aimed at testing for anti-inflammatory, antiulcerative, antihyperglycemic, and antidyslipidemic activities. Liver enzyme concentration (SGPT, SGOT) had also been assessed. After being extracted in organic solvent, 3 distinct doses, 100, 200, and 400 mg/kg b.w. (p.o.), were used. For edema formation 0.1 ml carrageenan at a dose of 1% w/v was injected into paw of left hind. It showed a fall of edemas 37.50%, 48.34%, and 55.83% while used doses were 100, 200, and 400 mg/kg b.w. (p.o.) individually. The EtOH extract of O. indicum (50%) and its fractions PET, CLF, EtOAc, and nBUT were studied against ethanol-induced gastric mucosal damage. Only PET and n-BuOH exhibited the highest percentage of protection and were 96% and 99%, respectively, persuaded by ethanol. In OGTT glibenclamide revealed reduction of glucose level to 7.55 ± 0.22 mmol/L from 10.57 ± 0.32 mmol/L after 30 minutes. Antihyperglycemic activities were assessed for 8- and 12-week duration in diabetic rats. Glibenclamide reduced glucose level from 33.50±0.31 to 7.90±0.19 mmol/L in 12 weeks. In 12 and 8 weeks, combination therapy lowered blood glucose level to a normal extent by 79% and 61% individually. In antidyslipidemic activities after 12-week treatment, it revealed simvastatin; MEOI (400 mg/kg b.w.) and combination of both reduced TC level by 44%, 28%, and 48% consequently followed by TG and LDL. In 8-week treatment, HDL levels were increased by 34%, 13%, and 36%, and in 12 weeks increased by 36%, 8%, and 38% consequently. Liver enzyme concentration after 12 weeks of treatment with glibenclamide, 400 mg/kg b.w. (p.o.) of MEOI and combination of both, exhibited the fact that concentration of SGPT showed downturn by 43.23%, 8.01%, and 54.86% and SGOT by 42.40%, 5.31%, and 44.85%. This study remarked that O. indicum has anti-inflammatory, antiulcer, antidiabetic, and antidyslipidemic potentials but has no ameliorative effect on liver enzyme.

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“…Fourier Transform Infrared Spectroscopy is one of the extensively used approaches as it is highly sensitive, reliable, nondestructive, and rapid detection technique which is beneficial to determine the functional groups of chemical compounds. FTIR has the ability to detect various wavelengths that is used to identify the presence of carboxylic acid, amines, amides, amino acids, aromatic compounds and others in the plant sample (Bhat et al, 2015).…”

Section: Literature Reviewmentioning

confidence: 99%

Identification of Chemical Constituents of Oroxylum Indicum (Bonglai) Hydrosol (Remaining Water After Oil Distillation) Extracted By Hydrodistillation Method

Azhar

Aziz

Hairunnaja

et al. 2022

EASTJ

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Oroxylum Indicum (Indian Trumpet Flower) or called Bonglai in Malay is a medicinal plant widely used, especially in the Indian medicine system. Oroxylum Indicum can be extracted by the hydrodistillation method to obtain the essential oil and hydrosol. Nevertheless, the chemical constituents of the hydrosol of the leaves are yet to be determined as hydrosol is always discarded, leading to the wastage of products. Thus, this study investigated the chemical constituents of Oroxylum Indicum leaves hydrosol extracted by hydrodistillation by varying temperatures and determined the functional groups of the active constituents in the leaves for the benefit and usage in pharmaceutical industries. Hydro distillation is carried out at different temperatures to study the effect of temperatures on the active compounds in the hydrosol. The hydrosol sample of the leaves will be extracted by hydrodistillation method at temperatures of 50℃, 70℃ and 80℃ and separated via rotary evaporator, and later analyzed by GC-MS and FTIR analysis. This study will help us to identify the value and amount yield of the chemical constituents of Oroxylum Indicum leaves hydrosol which will be able to determine whether it will have significant values equal to the essential oil. From FTIR analysis, the functional groups for all samples are the same which are O-H stretch, H- bonded, N-H stretch and C=C stretch. The chemical constituents of Oroxylum Indicum hydrosol were determined by GC-MS analysis. The major components of hydrosol produced at 50℃ are squalene (10.44%), 2ethylehexyl palmitate (8.56%), palmitic acid (7.50%), and di-n-2-propyl pentyl phthalate (1.69%), and at 70℃ is acetic acid (5.88%) only, while at 80℃ are only traces components respectively. This is due to most compounds contained may be decomposed during the preparation of samples prior to both analyses also the efficiency of the system and procedure during the extraction.

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A Promising Approach Toward Exploring Nutritional and Functional Qualities of Beko (O roxylum Indicum L. Benth. Ex Kurz) Pods For Potential Food Applications

Cited by 7 publications

References 38 publications

Intracellular ROS Scavenging and Anti‐Inflammatory Activities of Oroxylum indicum Kurz (L.) Extract in LPS plus IFN‐γ‐Activated RAW264.7 Macrophages

Intracellular ROS Scavenging and Anti‐Inflammatory Activities of Oroxylum indicum Kurz (L.) Extract in LPS plus IFN‐γ‐Activated RAW264.7 Macrophages

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Identification of Chemical Constituents of Oroxylum Indicum (Bonglai) Hydrosol (Remaining Water After Oil Distillation) Extracted By Hydrodistillation Method

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