A progressive review of Sandhana kalpana (Biomedical fermentation): An advanced innovative dosage form of Ayurveda

Abstract

Sandhana kalpana (biomedical fermented formulations) are one of the best dosage forms of Ayurveda in practice since thousands of years. In order to prepare these medicaments, certain sets of conditions are prearranged, which lead to fermentation. Thus, products bequeath with self-generated ethyl alcohol, which potentiate these preparations (Asava–Arishta), pharmaceutically and therapeutically. Commonly, medicinal and commercial components of these formulations are prompting many researchers to contribute in manufacturing, quality control, safety, and efficacy of these formulations. To cope up with this, literature related to Asava–Arishta has been surveyed from the Vedic period to recent publications of Government of India, ie, Ayurvedic Formulary of India, and presented briefly here. In this review paper, we have discussed pioneering facts such as nature and amount of carbohydrate, type of containers, optimum temperature, variety and relevance of initiator of fermentation, manufacturing, regulatory rules, and business aspects of Asava-Arishta. After going through this basic information, any academician or researcher may show a way to further strengthen this dosage form.

Ayurvedic Liquid Dosage form Asava and Arista: An Overview

“…Where as in cold decoction, yeast cells were not destroyed and assists the fermentation process. 38,39 In the ancient time, containers for preparation of Asavarista were placed in Dhanya Rashi (Ex-Kanakbindu arista), Bhugarbha (Ex-Kharjurasava), Koshthasara (Ex-Kumaryasava), etc in order avoid minimum temperature variation. Optimum temperature in the range of 20-35°C is suitable for initiation of fermentation.…”

Fermentation in ancient Ayurveda: Its present implications

“…Bouldin et al (1999) observed that Ayurvedic remedies were considered cheap, inherently safe and with few side-effects. Chaudhury et al (2011) reviewed the literature related to asava and arishta from the Vedic period to recent publications of the Government of India, i.e. the Ayurvedic Formulary of India.…”

Untitled

“…The alcohol generated in these formulation act as driver for bio absorption, enhancing bioavailability and to increase shelf life of the formulation. Self-generated alcohol also serves as hydro alcoholicmilieu for continuous extraction and preservation of the extract suspended in formulation 33 .…”