A progressive-duration schedule of reinforcement

Gulotta, Kara B.; Byrne, Tom

doi:10.1016/j.beproc.2015.10.022

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…Regarding this issue, what is the maximum duration the group No-Timeout (which increments the criterion in steps) can achieve? Gulotta and Byrne (2015) showed…”

Section: Discussionmentioning

confidence: 99%

Rats can learn a temporal task in a single session

Reyes

Miranda

Tunes

et al. 2019

Preprint

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Fixed interval, peak interval, and temporal bisection procedures have been used to assess cognitive functions and address questions such as how animals perceive, represent, and reproduce time intervals. They have also been extensively used to test the effects of drugs on behavior, and to describe the neural correlates of interval timing.However, those procedures usually require several weeks of training for behavior to stabilize. Here, we compared three types of training protocols and reported a procedure in which performance by the end of the very first session nearly matches the performance of long-term training. We also discuss this fast-learning protocol in terms of an information-theory approach. This one-day training protocol can be used to investigate temporal learning and may be especially useful to electrophysiological and neuropharmacological studies.

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“…Regarding this issue, what is the maximum duration the group No-Timeout (which increments the criterion in steps) can achieve? Gulotta and Byrne (2015) showed…”

Section: Discussionmentioning

confidence: 99%

Rats can learn a temporal task in a single session

Reyes

Miranda

Tunes

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…Regarding this issue, what is the maximum duration the group No-Timeout (which increments the criterion in steps) can achieve? Gulotta and Byrne (2015) showed that animals were able to keep a lever pressed for about 20 s. And, as argued above, such long responses would not occur in a Fixed protocol. Consequently, there is probably an intermediate protocol, perhaps a combination of the No-Timeout and Fixed, that would generate faster learning of longer responses.…”

mentioning

confidence: 82%

Rats can learn a temporal task in a single session

Reyes

Miranda

Tunes

et al. 2020

Behavioural Processes

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“…After evaluating post-IA operant self-administration, we tested rats on a progressive ratio schedule of reinforcement to investigate motivation to obtain alcohol (301,322). We found that rats were slightly more motivated to work for and consume mildly more alcohol after exposure to the IA procedure as reflected by the breakpoint and intake value which was significantly higher compared to the controls.…”

Section: Intermittent Access To Alcohol Resulted In Escalated Alcoholmentioning

confidence: 96%

Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

Aziz¹

2017

Linköping University Medical Dissertations

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Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. There are only a few currently available treatments with narrow efficacy and variable patient response. Thus it is important to find new, more effective medications to increase the number of patients who can benefit from pharmacological treatment of AUD.The research presented in this thesis work focuses on the critical involvement of central neuropeptides in alcohol-related behaviors. The overall aim was to evaluate the nociceptin/orphanin FQ (NOP) receptor, the neuropeptide Y (NPY) Y2 receptor and the melanin-concentrating hormone (MCH) receptor 1 as novel and potential pharmacological treatment targets for AUD by testing the NOP receptor agonist SR-8993, the NPY-Y2 receptor antagonist CYM-9840 and the MCH1 receptor antagonist GW803430 in established animal models.In the first study (Paper I), the novel and selective NOP agonist SR-8993 was assessed in rat models of motivation to obtain alcohol and relapse to alcohol-seeking behavior using the operant self-administration (SA) paradigm. Firstly, treatment with SR-8993 (1 mg/kg) showed a mildly anxiolytic effect and reversed acute alcohol withdrawal-induced "hangover" anxiety in the elevated plus-maze (EPM). Next, it potently attenuated alcohol SA and motivation to obtain alcohol in the progressive ratio responding (PRR) and reduced both alcohol cue-induced and yohimbine stressinduced reinstatement of alcohol seeking, without affecting the pharmacology and metabolism of alcohol nor other control behaviors. To extend these findings, SR-8993 was evaluated in escalated alcohol-intake in rats. Treatment with SR-8993 significantly suppressed alcohol-intake and preference in rats that were trained to consume high amounts of alcohol in the two-bottle free choice intermittent access (IA) paradigm. SR-8993 also blocked operant SA of alcohol in rats that showed robust escalation in operant alcohol SA following chronic IA exposure to alcohol.In the second study (Paper II), SR-8993 was further evaluated in a model for escalated alcohol-intake induced by long-term IA exposure to alcohol. The effect of previous experience on operant alcohol SA on two-bottle free choice preference drinking was evaluated and sensitivity to treatment with SR-8993 was tested in rats selected for escalated and non-escalated alcohol seeking behavior. We found that rats exposed to the combined SA-IA paradigm showed greater sensitivity to SR-8993 treatment. In addition, acute escalation of alcohol SA after a three-week period of abstinence was completely abolished by pretreatment with SR-8993.In the third study (Paper III), the effects of the novel, small molecule NPY-Y2 antagonist CYM-9840 were tested in operant alcohol SA, PRR which is a model for...

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A progressive-duration schedule of reinforcement

Cited by 12 publications

References 21 publications

Rats can learn a temporal task in a single session

Rats can learn a temporal task in a single session

Rats can learn a temporal task in a single session

Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

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