A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting

Luo, Yingping; Huang, Liwei; Yang, Ye; Zhuang, Xianfei; Hu, Siyao; Ju, Huangxian; Yu, Boyang; Tian, Jiangwei

doi:10.7150/thno.18187

Cited by 16 publications

(28 citation statements)

References 37 publications

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“…These results were ascribed to the pH-triggered charge-switching of the PVD-NPs. PEG functionalized and negatively charged nanoparticles can minimize nonspecific serum protein absorption and prolong circulation time, 34,35 which is consistent with the results of the stability assay (Figure 2E and F). In addition, positively charged NPs can promote cell uptake and subsequent drug accumulation at tumor sites.…”

Section: Surface Charge Conversion Capacity Of Pvd-npssupporting

confidence: 86%

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

Chen

Song

et al. 2020

IJN

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Poor cell uptake and incomplete intracellular drug release are the two major challenges for polymeric prodrug-based drug delivery systems (PPDDSs) in cancer treatment. Methods: Herein, a PPDDS with pH-induced surface charge-reversal and reactive oxygen species (ROS) amplification for ROS-triggered self-accelerating drug release was developed, which was formed by encapsulating a ROS generation agent (vitamin K3 (VK3)) in pH/ROS dual-sensitive polymetric prodrug (PEG-b-P(LL-g-TK-PTX)-(LL-g-DMA)) based micelle nanoparticles (denoted as PVD-NPs). Results: The surface charge of the PVD-NPs can change from negative to positive for enhanced cell uptake in response to tumor extracellular acidity pH. After internalization by cancer cells, PVD-NPs demonstrate dual drug release in response to intracellular ROS-rich conditions. In addition, the released VK3 can produce ROS under the catalysis by NAD(P)H: quinone oxidoreductase-1, which facilitates tumor-specific ROS amplification and drug release selectively in cancer cells to enhance chemotherapy. Conclusion: Both in vitro and in vivo experiments demonstrated that the PVD-NPs showed significant antitumor activity in human prostate cancer.

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Section: Surface Charge Conversion Capacity Of Pvd-npssupporting

confidence: 86%

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

Chen

Song

et al. 2020

IJN

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“…However, concerns about their uncertain architecture stability, complex pharmacokinetics, and potential increased toxicology remain a formidable challenge for their clinical application [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Therefore, it is essential to achieve single theranostic nanoparticles with intrinsic imaging and therapeutic capabilities [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency

2018

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Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo2C QDs) with a diameter of approximately 6 nm and a topographic height of about 1.5 nm were synthesized using a facile sonication-assisted liquid-phase exfoliation approach. The prepared Mo2C QDs exhibited a strong near-infrared (NIR) absorbance with a high molar extinction coefficient of 4.424 Lg−1cm−1 at 808 nm, a high photothermal conversion efficiency of 42.9%, and showed excellent performance on photoacoustic imaging. The Mo2C QDs had high stability and highly biocompatibility, with low cytotoxicity. Under NIR irradiation, a remarkable in vitro and in vivo therapeutic effect was obtained. Such a stable and biocompatible all-in-one theranostic nanoagent generated by facile synthesis that combines promising imaging guidance and effective tumor ablation properties may hold great potential for theranostic nanomedicine.

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“…However, because of high cytotoxicity and non-specificity to tumors, many chemotherapy drugs bring severe side effects, which exert pronounced suffering to patients and make them unfit for long-term therapy 3 - 5 . Currently, among the various approaches to improve the effectiveness of chemotherapy drugs, controlled drug delivery systems that can convey chemotherapeutic drugs safely and efficaciously have attracted great attention 6 - 12 . A desirable controlled release system should: 1) be easy to prepare with high purity; 2) accumulate more in cancer than normal cells; 3) exhibit minimal cytotoxicity to normal cells; 4) have favorable controlled release to prolong the acting time and avoid multiple dosing; 5) enable direct and real-time monitoring of the drug release dynamics with high accuracy in a noninvasive manner 13 - 15 .…”

Section: Introductionmentioning

confidence: 99%

Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues

et al. 2018

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Controlled release systems with capabilities for direct and real-time monitoring of the release and dynamics of drugs in living systems are of great value for cancer chemotherapy. Herein, we describe a novel dual turn-on fluorescence signal-based controlled release system (CDox), in which the chemotherapy drug doxorubicin (Dox) and the fluorescent dye (CH) are conjugated by a hydrazone moiety, a pH-responsive cleavable linker. CDox itself shows nearly no fluorescence as the fluorescence of CH and Dox is essentially quenched by the C=N isomerization and N-N free rotation. However, when activated under acidic conditions, CDox could be hydrolyzed to afford Dox and CH, resulting in dual turn-on signals with emission peaks at 595 nm and 488 nm, respectively. Notably, CDox exhibits a desirable controlled release feature as the hydrolysis rate is limited by the steric hindrance effect from both the Dox and CH moieties. Cytotoxicity assays indicate that CDox shows much lower cytotoxicity relative to Dox, and displays higher cell inhibition rate to cancer than normal cells. With the aid of the dual turn-on fluorescence at different wavelengths, the drug release dynamics of CDox in living HepG2 and 4T-1 cells was monitored in double channels in a real-time fashion. Importantly, two-photon fluorescence imaging of CDox in living tumor tissues was also successfully performed by high-definition 3D imaging. We expect that the unique controlled release system illustrated herein could provide a powerful means to investigate modes of action of drugs, which is critical for development of much more robust and effective chemotherapy drugs.

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A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting

Cited by 16 publications

References 37 publications

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>

A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency

Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues

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