A programmable calculator program for rapid logarithmic extrapolation, and calculation of mean transit time from an indicator-dilution curve

Lin, Yue-Hsin

doi:10.1016/0010-468x(79)90026-6

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Extrapolation of the downslope of the dye dilution curves and calculations of mean transit time, cardiac output and central blood volume were performed with the aid of a program for a hand-held computer, published by Lin [9].…”

Section: Calculationsmentioning

confidence: 99%

Pulmonary Kinetics of Fentanyl and Alfentanil in Surgical Patients

Taeger

Weninger

Schmelzer

et al. 1988

British Journal of Anaesthesia

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Lipid-soluble basic drugs may be sequestered as the drug-loaded blood passes through the pulmonary capillaries [1], and the amount of drug remaining in the blood for distribution to the organism may be substantially reduced by this mechanism. The temporary sequestration of a significant proportion of an i.v. dose of a drug by the lung may influence the intensity and duration of its pharmacological effect [2]. Hess, Herz and Friedel [3] reported that rabbit lung had a high affinity for fentanyl: approximately 24 % of the dose administered was sequestered as the drug passed through the lung for the first time ("first pass"). Several reports demonstrated a high fentanyl binding capacity of the human lung [4-7]. This paper describes quantitatively the pulmonary kinetics of fentanyl and alfentanil in patients suffering from coronary artery disease. PATIENTS AND METHODS After approval was granted by the local ethics committee for an investigation into the pulmonary kinetics of fentanyl and alfentanil in surgical patients, informed consent was obtained from 11 patients (10 male) scheduled to undergo elective coronary artery bypass surgery. Patients ranged in age from 36 to 67 yr and in body weight from 71 to 81 kg. They were divided into two groups: fentanyl (five patients; Nos 1-5. No. 5 was the

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Section: Calculationsmentioning

confidence: 99%

Pulmonary Kinetics of Fentanyl and Alfentanil in Surgical Patients

Taeger

Weninger

Schmelzer

et al. 1988

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Finally, the program CRDOUT analyzes the dye-dilution curve in a manner similar to previously described methods (Lin, 1979;Cole and Crawford, 1980). After computing the estimated downslope to eliminate the effect of recirculation, the area under the curve and resultant cardiac output is computed.…”

Section: Development Of the Mathematical Modelmentioning

confidence: 99%