A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing

Abstract

Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature–activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.

Wireless‐Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing

“…This flexible dressing achieves effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively; moreover, the wound healing rate increased more than 50% compared with the blank control group. [ 42 ] Moreover, the effects of AC and DC on wound recovery are often related to the specific cells and animal tissues. [ 41 , 42 , 43 , 44 , 54 ] In this study, the use of DC was optimized according to the results of cell and rabbit model experiments.…”

“…[ 42 ] Moreover, the effects of AC and DC on wound recovery are often related to the specific cells and animal tissues. [ 41 , 42 , 43 , 44 , 54 ] In this study, the use of DC was optimized according to the results of cell and rabbit model experiments. Furthermore, the electrical stimulation signal for wound recovery can be regulated according to different cells or tissues.…”

Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues

“…Second, nanoridges that are aligned perpendicular to the guidance cue can provide strong local steering without significantly diminishing the effectiveness of the unidirectional guidance cue. Therefore, our work has implications for real wound sites, which include not only EFs, but also multiple chemotactic signals that act on cellular scales ( Liu et al, 2021 ; Moarefian et al, 2021 ; Yao et al, 2022 ). Our results indicate that when nanotopography is the only local guidance cue, cells can respond to this texture while still moving toward the site of a wound.…”

Smart Polycationic Hydrogel Dressing for Dynamic Wound Healing

“…The process of wound healing is divided into hemostatic phase, inflammatory phase, proliferative phase, and remodeling phase. [6,60,61] Among them, the inflammation of the wound would be accompanied by a fever and the temperature of the inflamed wound is about 38-40 °C. [62] According to the linear responsive relationship between the relative resistance and temperature of the hydrogel in the range of 34-42 °C, the hydrogel can be applied in the dynamic monitoring of the wound healing.…”