A Prognostic Score for Predicting Survival in Patients With Pancreatic Head Adenocarcinoma and Distal Cholangiocarcinoma

Muttillo, Edoardo Maria; Ciardi, Antonio; Saullo, Paolina; Troiano, Raffaele; Masselli, Gabriele; Guida, Marianna; Tortora, Alessandra; Sperduti, Isabella; Marinello, Giulio; Chirletti, Piero; Caronna, Roberto

doi:10.21873/invivo.12285

Cited by 7 publications

(9 citation statements)

References 36 publications

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“…The prognosis of patients with DCCA is significantly better than that of patients with PDCA in our analysis (p < 0.00001), which is in line with the observations reported by others ( 4 – 6 , 9 , 35 ). The most likely explanation for this phenomenon is that patients with PDCA were more frequently diagnosed in an advanced stage with delayed-observed obstructive jaundice.…”

Section: Discussionsupporting

confidence: 93%

“…Initially, 12 studies ( 1 , 4 – 9 , 12 – 16 ) were identified through our search strategy. However, the study by Yeo et al.…”

Section: Resultsmentioning

confidence: 99%

“…was excluded. Consequently, a total of 11 studies ( 1 , 4 – 9 , 12 – 15 ) with 4,698 patients with DCCA and 100,629 patients with PDCA were incorporated into our analysis. Except for the study by Garnier et al.…”

Section: Resultsmentioning

confidence: 99%

“…There are no specific tumor biomarkers to date to distinguish them clearly (4). Moreover, accumulating evidence has suggested that despite their similar origin and surgical techniques, their clinical-pathological features and long-term prognosis were reported to be inconsistent to some extent (4)(5)(6)(7)(8)(9). For example, Andrianello et al revealed that lymphatic invasion and neural invasion were more frequently detected in patients with PDCA, and patients with DCCA had a significantly better prognosis (5).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Wang

et al. 2022

Front. Oncol.

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ObjectiveTo evaluate the consistencies and inconsistencies between distal cholangiocarcinoma (DCCA) and pancreatic ductal adenocarcinoma (PDCA) regarding their biological features and long-term prognosis.MethodsPubMed, the Cochrane Library, and EMBASE were searched to find comparative studies between DCCA and PDCA. RevMan5.3 and Stata 13.0 software were used for the statistical analyses.ResultsEleven studies with 4,698 patients with DCCA and 100,629 patients with PDCA were identified. Pooled results indicated that patients with DCCA had a significantly higher rate of preoperative jaundice (p = 0.0003). Lymphatic metastasis (p < 0.00001), vascular invasion (p < 0.0001), and peri-neural invasion (p = 0.005) were more frequently detected in patients with PDCA. After curative pancreaticoduodenectomy (PD), a significantly higher R0 rate (p < 0.0001) and significantly smaller tumor size (p < 0.00001) were detected in patients with DCCA. Patients with DCCA had a more favorable overall survival (OS) (p < 0.00001) and disease-free survival (DFS) (p = 0.005) than patients with PDCA. However, postoperative morbidities (p = 0.02), especially postoperative pancreatic fistula (POPF) (p < 0.00001), more frequently occurred in DCCA.ConclusionPatients with DCCA had more favorable tumor pathological features and long-term prognosis than patients with PDCA. An early diagnosis more frequently occurred in patients with DCCA. However, postoperative complications, especially POPF, were more frequently observed in patients with DCCA.

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Section: Discussionsupporting

confidence: 93%

“…Initially, 12 studies ( 1 , 4 – 9 , 12 – 16 ) were identified through our search strategy. However, the study by Yeo et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Wang

et al. 2022

Front. Oncol.

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Impact of radiological and pathological splenic vein involvement in patients with resectable pancreatic body or tail cancer

Kuriyama,

Mizuno,

Sakamoto

et al. 2024

Langenbecks Arch Surg

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Several studies have reported a negative impact on survival associated with splenic vessel involvement, especially splenic artery (SpA) involvement, in patients diagnosed with pancreatic body or tail cancer.However, there is limited research on splenic vein (SpV) involvement. Therefore, we aimed to elucidate the signi cance of splenic vessel involvement, especially SpV involvement, in patients with resectable pancreatic body or tail cancer. MethodsBetween January 2007 and December 2021, 116 consecutive patients underwent distal pancreatectomies for pancreatic body or tail cancer. Among them, this study speci cally examined 88 patients with resectable pancreatic body or tail cancer to elucidate prognostic factors using a multivariable Cox proportional analysis. The Kaplan-Meier method evaluated the impact of SpV involvement in terms of both radiological and pathological aspects and the e cacy of neoadjuvant therapy. ResultsHigher pre-operative carcinoembryonic antigen levels, larger tumour size, pathological SpV invasion, and non-completion of adjuvant therapy were identi ed as independent poor prognostic factors for overall survival (OS) and recurrence-free survival (RFS). Additionally, patients with radiological SpV encasement had signi cantly worse prognoses in terms of OS (p = 0.039) and RFS (p < 0.001). The sensitivity and speci city of multidetector-row computed tomography for detecting pathological SpV invasion were 81.0% and 61.2%, respectively. However, the prognostic impact of neoadjuvant therapy could not be determined, regardless of radiological SpV involvement. ConclusionRadiological and pathological SpV involvement is a poor prognostic factor for patients with resectable pancreatic body or tail cancer. New innovative treatments and effective neoadjuvant therapy regimens are required for patients with SpV involvement.

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The Role of Diffusion-Weighted Magnetic Resonance Imaging in Staging after Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Adenocarcinoma

Muttillo

Felli²

2022

Ann Surg Oncol

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A Prognostic Score for Predicting Survival in Patients With Pancreatic Head Adenocarcinoma and Distal Cholangiocarcinoma

Cited by 7 publications

References 36 publications

The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Impact of radiological and pathological splenic vein involvement in patients with resectable pancreatic body or tail cancer

The Role of Diffusion-Weighted Magnetic Resonance Imaging in Staging after Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Adenocarcinoma

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