A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma

Ji, Lina; Zhang, Qianqian; Cao, Yumeng; Liu, Lixin

doi:10.1007/s13577-023-00885-8

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…GPT2 was up-regulated, and EFHC2 was down-regulated in SCLC tissues compared to non-tumoral lung tissues. Glutamic pyruvic transaminase 2 (GPT2), also known as alanine aminotransferase 2 (ALT2) expression, has been shown to be associated with good prognosis in hepatocellular carcinoma [84] and poor prognosis in breast cancer [85]. In this study, GPT2 mRNA expression was associated with a good prognosis.…”

Section: Discussionmentioning

confidence: 69%

A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection

Atay

2023

Cancers

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Small cell lung cancer (SCLC) is a malignancy with a poor prognosis whose treatment has not progressed for decades. The survival benefit of surgery and the selection of surgical candidates are still controversial in SCLC. This study is the first report to identify transcriptomic alterations associated with prognosis and propose a gene expression-based risk signature that can be used to predict overall survival (OS) in SCLC patients who have undergone potentially curative surgery. An integrative transcriptome analysis of three gene expression datasets (GSE30219, GSE43346, and GSE149507) revealed 1734 up-regulated and 2907 down-regulated genes. Cox-Mantel test, Cox regression, and Lasso regression analyses were used to identify genes to be included in the risk signature. EGAD00001001244 and GSE60052-cohorts were used for internal and external validation, respectively. Overall survival was significantly poorer in patients with high-risk scores compared to the low-risk group. The discriminatory performance of the risk signature was superior to other parameters. Multivariate analysis showed that the risk signature has the potential to be an independent predictor of prognosis. The prognostic genes were enriched in pathways including regulation of transcription, cell cycle, cell metabolism, and angiogenesis. Determining the roles of the identified prognostic genes in the pathogenesis of SCLC may contribute to the development of new treatment strategies. The risk signature needs to be validated in a larger cohort of patients to test its usefulness in clinical decision-making.

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Section: Discussionmentioning

confidence: 69%

A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection

Atay

2023

Cancers

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“…In addition, Yang et al found methionine adenosyltransferase 2A (MAT2A), which participates in the methionine cycle, can synergize with ACSL3 to suppress ferroptosis by enhancing the promoter of ACSL3 [71]. Additionally, it has been found that cystathionine β-synthase (CBS), glutamic pyruvic transaminase 2 (GPT2) and suppressor of variegation 3-9 homolog 1 (SUV39H1) are related to amino acid metabolism and ferroptosis [72]. CBS, a rate-limiting enzyme in the transsulfuration pathway, catalyzes the irreversible transformation of homocysteine and serine to cystathionine, which is the precursor of cysteine [73,74].…”

Section: Other Amino Acidsmentioning

confidence: 99%

Metabolism-regulated ferroptosis in cancer progression and therapy

Ye,

Wen,

Qin

et al. 2024

Cell Death Dis

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Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferroptosis is a regulated cell death induced by iron-dependent lipid peroxidation, which is morphologically different from apoptosis, necrosis, necroptosis, pyroptosis, autophagy-dependent cell death and cuprotosis. Cancer metabolism plays opposite roles in ferroptosis. On the one hand, carbohydrate metabolism can produce NADPH to maintain GPX4 and FSP1 function, and amino acid metabolism can provide substrates for synthesizing GPX4; on the other hand, lipid metabolism might synthesize PUFAs to trigger ferroptosis. The mechanisms through which cancer metabolism affects ferroptosis have been investigated extensively for a long time; however, some mechanisms have not yet been elucidated. In this review, we summarize the interaction between cancer metabolism and ferroptosis. Importantly, we were most concerned with how these targets can be utilized in cancer therapy.

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Protective effects of puerarin on liver tissue in Salmonella-infected chicks: a proteomic analysis

Lu,

Guo,

et al. 2024

Poultry Science

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A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma

Cited by 3 publications

References 61 publications

A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection

A 15-Gene-Based Risk Signature for Predicting Overall Survival in SCLC Patients Who Have Undergone Surgical Resection

Metabolism-regulated ferroptosis in cancer progression and therapy

Protective effects of puerarin on liver tissue in Salmonella-infected chicks: a proteomic analysis

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