A prognostic model for advanced stage nonsmall cell lung cancer

Abstract

Background Radiographic shadows of coal workers' pneumoconiosis (CWP) are commonly described as predominantly in the upper lung zones. Methods We evaluated the lung distribution of small opacities on surveillance chest radiographs (CXRs) taken between 1981 and 2010 among 2,467 underground US coal miners. All had evidence of pneumoconiosis (category ≥1/0), based on the contemporary International Labour Office Classification of Radiographs of Pneumoconioses. Results Small opacity involvement was approximately equal over all lung zones, with 30.7% of the total involvement reported in the upper zones, 37.1% in the middle zones, and 32.1% in the lower zones. Primarily rounded opacities were seen in 62.1% of miners and primarily irregular opacities were seen in 37.9%. Miners with primarily rounded opacities had a distribution with moderate upper zone predominance (upper = 36.8%, middle = 36.5%, and lower = 27.2%). In contrast, miners with primarily irregular opacities showed a lower zone preponderance (upper = 20.5%, middle = 38.4%, and lower = 41.1%). Conclusion The distribution of small pneumoconiotic opacities on surveillance CXRs of working US coal miners is not consistent with the conventional expectations of upper lung zone predominance. Am. J. Ind. Med. 55:793–798, 2012. © 2012 Wiley Periodicals, Inc.

Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer

“…In the current study, the one-year survival rate was 52.3% (i.e., >50%). This finding shows that one-year survival rate in the present study was in line with the literature [41, 42]. …”

“…Although radiotherapy and multiagent chemotherapy are used in the treatment of patients with ES-NSCLC, the prognosis remains poor, with a median survival of 6 to 12 months and 1-year survival rates between 20% and 50% [41, 42]. In the current study, the one-year survival rate was 52.3% (i.e., >50%).…”

Smoking and Prognostic Factors in an Observational Setting in Patients with Advanced Non-Small Cell Lung Carcinoma

“…In this study, disease stage was also identified as an independent prognostic factor, with improved survival noted in those patients with Grade IIIB NSCLC when compared with Grade IV disease. Similar findings have been shown in other studies 19,24. T-stage was also shown to be an independent prognostic factor in our study, with improved survival observed in patients with T1 stage compared with T2-TX.…”

Peripheral blood lymphocyte/monocyte ratio at the time of first relapse predicts outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma

“…Myeloid-lineage cells, including monocytes and their progeny, promote tumorigenesis and angiogenesis [35], and contribute to the suppression of host antitumor immunity so that not surprisingly then, development of peripheral blood neutrophilia or monocytosis are adverse prognostic factors in multiple solid tumors [36-38]. A new nomenclature defines human monocyte subsets into three, classical (CD14++CD16-), intermediate (CD14++CD16+) and nonclassical (CD14 + CD16++) [39].…”