A Profile of Adverse Drug Reactions of Atazanavir- and Lopinavir-Based Antiretroviral Regimens in Namibia

Adenuga, Babafunso Aderemi; Rennie, Timothy

doi:10.1007/s40264-019-00832-3

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Training also appeared to be an important factor that may be related to ADR reporting practices . In a recent audit carried out between August 2017 and August 2018, using the Individual Case Safety Report (ICSR) submitted by healthcare workers to TIPC, it was found that, although patients may be experiencing ADRs due to atazanavir‐ and lopinavir‐containing regimens, cases were under‐reported, though; the under‐reporting may not be limited to these regimens.…”

Section: Discussionmentioning

confidence: 99%

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Optimizing spontaneous adverse drug reaction reporting in public healthcare setting in Namibia

Adenuga

Kibuule

Rennie

2019

Basic Clin Pharma Tox

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Despite the universal scale‐up of pharmacovigilance systems globally, adverse drug reaction (ADR) reporting remains suboptimal among resource‐limited countries. Few studies in sub‐Saharan Africa evaluate the effectiveness of adverse drug reaction (ADR) reporting programmes. A cross‐sectional survey using a self‐administered questionnaire to assess ADR reporting knowledge, attitude and practices among healthcare workers in Namibia's public sector was conducted between September and December 2018. The primary outcome were practices, knowledge and attitude of the respondents towards ADR reporting. Quantitative and qualitative data were analysed using descriptive statistics and thematic analysis, respectively. Of the 197 healthcare workers surveyed, 43.1% were nurses, 63.4% of the respondents knew about the ADR reporting system in Namibia, 76.7% knew the pharmacovigilance/ADR reporting centre in Namibia, while 37.3% had reported an ADR before. Nurses were less likely to be knowledgeable and report ADRs. The independent predictor of ADR reporting was the nursing cadre; adjusted odds ratio (aOR) = 0.17 (95% CI: 0.07, 0.401, P < .01). Pre‐ and in‐service trainings including introduction of electronic reporting platforms were some of the identified ways of optimizing the pharmacovigilance and ADR reporting systems by the respondents. As pharmacovigilance in Namibia relies on spontaneous reporting of ADRs, there is a need for advocacy and workforce strengthening for ADR reporting in the public health sector.

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Section: Discussionmentioning

confidence: 99%

“…found that, although patients may be experiencing ADRs due to atazanavir-and lopinavir-containing regimens, cases were under-reported, 14 though; the under-reporting may not be limited to these regimens. Respondents themselves suggested that training and education around pharmacovigilance could empower current systems of reporting.…”

Section: Community Engagementmentioning

confidence: 99%

Optimizing spontaneous adverse drug reaction reporting in public healthcare setting in Namibia

Adenuga

Kibuule

Rennie

2019

Basic Clin Pharma Tox

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“…Incentives such Continuing Professional Development (CPD) points, can serve as an encouragement for some healthcare workers. This was highlighted by respondents in study carried out by Adenuga et al [14].…”

Section: Introducing Pharmacovigilance Into the Curriculum Of Healthc...mentioning

confidence: 91%

“…Healthcare workers in both public and private healthcare facilities in Namibia are believed to under-report ADRs; this might be partly due to a poor acceptance and implementation of pharmacovigilance systems at health facility level [13,14]. In most LMICs such as Ethiopia, among the factors that promote underreporting of ADRs, are lack of awareness of ADRs Monitoring Centres (AMC) and pharmacovigilance program in the settings, complacency, lack of training to identify ADRs etc.…”

Section: Making a Case For Improved Pharmacovigilancementioning

confidence: 99%

Embracing the Changing Needs for Pharmacovigilance in Africa

Adenuga¹

2023

Pharmacovigilance - Volume 2

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Growing burden of communicable and non-communicable diseases in sub-Saharan Africa has necessitated the need for increased medicine use among the African population. Owing to the limited manufacturing capacity of medicines in the sub-continent, it became imperative for governments and Central Medical Stores to source medicines from countries such as India, Bangladesh and China. Such procurements were due to the affordability of generic products manufactured by manufacturers in these countries compared to innovator s, which might come at exorbitant prices and costs that might be prohibitive for most developing countries such as the ones in sub-Saharan Africa. Ascertaining the quality and efficacy of these products are always reliant on the judgment of national regulatory authorities (NRA), which might be ill equipped in most instances; human capacity both in knowledge and number are some of the banes of such NRAs. Aforesaid, pharmacovigilance does not take the front seat in most discussions rather the burden of diseases, thus the emphasis on medicines availability. Different researchers have highlighted the link between medicines/drugs availability and the need for pharmacovigilance among healthcare workers, policy makers and patients. Such approach will tend to limit the procurement of medicines that are substandard, falsified or fake, with the aim of protecting public health.

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Effective integration of pharmacovigilance systems at public health facilities in resource-limited settings: A qualitative study

Adenuga

Kibuule

Bamitale

et al. 2020

Research in Social and Administrative Pharmacy

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A Profile of Adverse Drug Reactions of Atazanavir- and Lopinavir-Based Antiretroviral Regimens in Namibia

Cited by 3 publications

References 4 publications

Optimizing spontaneous adverse drug reaction reporting in public healthcare setting in Namibia

Optimizing spontaneous adverse drug reaction reporting in public healthcare setting in Namibia

Embracing the Changing Needs for Pharmacovigilance in Africa

Effective integration of pharmacovigilance systems at public health facilities in resource-limited settings: A qualitative study

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