A profile for molecular biology databases and information resources

Kamel, Nabil

doi:10.1093/bioinformatics/8.4.311

Cited by 6 publications

(4 citation statements)

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“…Genome Sequences Molecular sciences are heavily dependent on the use of computers for accumulation, processing, analysis, storage, and dissemination of experimental data, and the role of transnational nucleic acid and protein sequence databases in these processes is crucial (reviewed in reference 275). Due to the increasing use of general sequence databases and the requirement for specialist functions, a number of specialist databases which cross-reference with major sequence databases have been formed (195). Even if an enterovirus molecular typing system were to use methods other than complete nucleotide sequencing of PCR products, it is likely that nucleotide sequencing of representative samples would still be required for ongoing quality assurance, discrepancy analysis, and resolution of untypeable samples.…”

Section: Formation Of a Database Of Enterovirusmentioning

confidence: 99%

Molecular Typing of Enteroviruses: Current Status and Future Requirements

et al. 1998

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Human enteroviruses have traditionally been typed according to neutralization serotype. This procedure is limited by the difficulty in culturing some enteroviruses, the availability of antisera for serotyping, and the cost and technical complexity of serotyping procedures. Furthermore, the impact of information derived from enterovirus serotyping is generally perceived to be low. Enteroviruses are now increasingly being detected by PCR rather than by culture. Classical typing methods will therefore no longer be possible in most instances. An alternative means of enterovirus typing, employing PCR in conjunction with molecular genetic techniques such as nucleotide sequencing or nucleic acid hybridization, would complement molecular diagnosis, may overcome some of the problems associated with serotyping, and would provide additional information regarding the epidemiology and biological properties of enteroviruses. We argue the case for developing a molecular typing system, discuss the genetic basis of such a system, review the literature describing attempts to identify or classify enteroviruses by molecular methods, and suggest ways in which the goal of molecular typing may be realized.

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Section: Formation Of a Database Of Enterovirusmentioning

confidence: 99%

Molecular Typing of Enteroviruses: Current Status and Future Requirements

et al. 1998

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“…One study [7] reveals that out of 92 database implementations of 73 different databases, 68 different DBMSs were used. Of those, 25 were inhouse products, 18 were commercially available relational systems (mainly Sybase, Oracle, and dbase), and the remaining ones consisted of a heterogeneous mix of commercial systems of different models.…”

Section: Background On Molecular Biology Databasesmentioning

confidence: 99%

“…The diversity among them becomes even harder to resolve. In addition, since those databases are autonomously developed, newer DBSs tend to use more recently available data models, DBMSs, etc., increasing the diversity among them even further [7].…”

Section: Related Workmentioning

confidence: 99%

“…Research performed by thousands of researchers around the world generates a steady stream of data on a daily basis. Much of the produced data is then stored and organized into hundreds of individual databases which are [7] distributed throughout the world. These databases, as a whole, have now become a powerful tool and a necessity for biologists in their research work.…”

Section: Introductionmentioning

confidence: 99%

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An approach for building an integrated environment for molecular biology databases

Kamel

Song

Kamel

1993

Distrib Parallel Databases

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Abstract. The requirements of a traditional integration of databases include hiding the heterogeneity among its member databases, preserving their autonomy, supporting controlled data sharing, and providing a user-friendly interface, with a performance comparable to that of a homogeneous distributed database system. In this paper, we describe a variation of the loosely coupled federated database approach that satisfies these requirements and is specifically oriented toward the special characteristics and needs of molecular biology databases. The approach differs from the traditional federated database approach in that it also integrates software tools together with the databases. In addition, the system gives the graphical user interface a more central role in the integration. Thus, the system has all the advantages provided by a visual user environment and is thus more user-friendly than traditional linguistic approaches. The paper also includes a description of XBio, a system which constructs such an integration. The design of XBio ensures robustness and can be customized to the needs of different classes of users.

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Programs, databases, and expert systems for human geneticists — a survey

et al. 1996

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We present an overview of the variety of databases and programs that offer substantial aid to medical and molecular geneticists. Databases and expert systems for genetic diseases and birth defects, programs for segregation and linkage analysis, certain DNA and protein sequence databases, and information resources in general for molecular biology are addressed. These systems cannot be used effectively without the newly developed techniques of information exchange based on international computer networks. A short introduction is given to the Internet and to European institutions and organizations that offer help with the acquisition and use of bioinformatic resources.

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A profile for molecular biology databases and information resources

Cited by 6 publications

References 0 publications

Molecular Typing of Enteroviruses: Current Status and Future Requirements

Molecular Typing of Enteroviruses: Current Status and Future Requirements

An approach for building an integrated environment for molecular biology databases

Programs, databases, and expert systems for human geneticists — a survey

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