A process synthesis-intensification method for generation of novel and intensified solutions

Synergistic Fermenter-Electrolytic Cell Integration and Phenomena-Based Process Intensification for Competitive Bio-Succinic Acid Production

“…In the present study, the batch fermentation that resulted as the best processing pathway for glycerol from the work of Dickson et al [9] (mathematical process synthesis) was substituted by a continuous fermentation integrated with an electrolytic cell (heuristic process intensification). Then, the phenomena-based process intensification framework developed by Lutze et al [22], Babi et al [23], and Garg et al [24] were applied (hybrid process intensification) to the integrated process. As a preliminary stage, the process flowsheet resulting from the integration of the electrolytic cell into the optimal pathway identified by Dickson et al [9,25] was modified to eliminate redundant equipment, such as the centrifuge and ion-exchange columns, whose tasks were accomplished by the electrolytic cell.…”

“…Then, the phenomena-based process intensification framework developed by Lutze et al [22], Babi et al [23], and Garg et al [24] were applied (hybrid process intensification) to the integrated process. As a preliminary stage, the process flowsheet resulting from the integration of the electrolytic cell into the optimal pathway identified by Dickson et al [9,25] was modified to eliminate redundant equipment, such as the centrifuge and ion-exchange columns, whose tasks were accomplished by the electrolytic cell. Subsequently, the adjusted flowsheet was subjected to a systematic phenomena-based process intensification based on the theoretical work of Garg et al [24] to generate more sustainable and innovative flowsheet alternatives for bio-succinic acid production from glycerol and carbon dioxide.…”

A Systematic Methodology for the Synthesis of Advanced Reactive Distillation Technologies

“…Synthesis methods that result in a conceptual flowsheet, following a process systems engineering approach, are also lacking . Methods for evaluating the feasibility of RD in a given context are limited to standalone units − or reactive separation systems, including conventional and intensified units. , However, synthesis and design of processes that apply ARDT have hardly been explored. In this work, the research question relates to whether a structured flowchart can be developed to identify which, if any, ARDT are best suited to exploit a given chemical reaction to produce a desired product.…”

Advancements in Optimization and Control Techniques for Intensifying Processes

“…Then, the most promising phenomena-based structures are transformed into unit operations [5,21]. Recent advancements using the PBBs methodology include the synthesis and intensification of the production of dimethyl carbonate with CO 2 utilization with consideration of operational feasibility, economics, life cycle assessment factors, and sustainability criteria [22], the dehydration of ethanol through a membrane-assisted distillation process (taking into account an economic criterion) [23], the transesterification of propylene carbonate with methanol to generate dimethyl carbonate and 1,2-propanediol (considering an economic criterion) [24], the intensification of the aldolization of an ethylene glycol and 1,2-butanediol mixture with acetaldehyde to produce 2-methyl-1,3-dioxolane and 4-ethyl-2-methyl-1,3-dioxolane [25], the esterification of isoamyl alcohol with acetic acid for the production of isoamyl acetate and the aldolization of ethylene glycol and 1,2-butanediol with acetaldehyde for the production of 2-methyl-1,3-dioxolane and 4-ethyl-2-methyl-1,3-dioxolane (taking into consideration an inherent safety assessment in addition to economic and sustainability criteria) [26], the production of ethylene glycol through the hydrolysis of ethylene oxide using an ε-constraint-based multiobjective optimization framework [27], the production of dimethyl ether from methanol (considering energy, CO 2 emissions, and sustainability indicators) [28], and the production of ethyl lactate from ethanol and lactic acid (considering economic, environmental, sustainability, and inherent safety criteria) [29]. In addition, Garg et al [30] presented the key concepts and step-by-step workflow of the phenomena-based intensification method for hybrid separation schemes along with a summary of published case studies with novel solutions for chemical and biochemical processes.…”