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AbstractPurpose -There is growing interest in self-management support for people living with mental health problems. The purpose of this paper is to describe the evaluation of a co-designed and co-delivered self-management programme (SMP) for people living with depression delivered as part of large scale National Health Service quality improvement programme, which was grounded in the principles of co-production. The authors investigated whether participants became more activated, were less psychologically distressed enjoyed better health status, and quality of life, and improved their self-management skills after attending the seven-week SMP. Design/methodology/approach -The authors conducted a longitudinal study of 114 people living with depression who attended the SMP. Participants completed self-reported measures before attending the SMP and at six months follow up. Findings -Patient activation significantly improved six months after the SMP (baseline M ¼ 49.6, SD ¼ 12.3, follow up M ¼ 57.2, SD ¼ 15.0, t(113) ¼ 4.83, po0.001; d ¼ 0.61). Participants' experience of depression symptoms as measured by the Patient Health Questionnaire-9 significantly reduced (baseline M ¼ 15.5, SD ¼ 6.8, follow up M ¼ 10.6, SD ¼ 6.9, t(106) ¼ 7.22, po 0.001, d ¼ −0.72). Participants' anxiety and depression as measured by the Hospital Anxiety Depression Scale also decreased significantly (baseline anxiety: M ¼ 13.1, SD ¼ 4.2, follow up M ¼ 10.2, SD ¼ 4.4, t(79) ¼ 6.29, p o0.001, d ¼ −0.69); (baseline depression: M ¼ 10.3, SD ¼ 4.6, follow up M ¼ 7.7, SD ¼ 4.5, t(79) ¼ 5.32, po 0.001, d ¼ −0.56). The authors also observed significant improvement in participants' health status (baseline M ¼ 0.5, SD ¼ 0.3, follow up M ¼ 0.6, SD ¼ 0.3, t(97) ¼ −3.86, po0.001, d ¼ 0.33), and health-related quality of life (baseline M ¼ 45.4, SD ¼ 20.5, follow up M ¼ 60.8, SD ¼ 22.8, t(91) ¼ −2.71, p ¼ 0.008, d ¼ 0.75). About 35 per cent of participant showed substantial improvements of self-management skills.Originality/value -The co-produced depression SMP is innovative in a UK mental health setting. Improvements ...