“…[5] To date the selective C5 À H/C7 À Hb orylation of indoles in the presence of C2 À H/ C3 À Hr equires prefunctionalised indoles (e.g.h alide at C5/ C7) or functionalisation of the more reactive C2ÀH/C3ÀH site prior to C5ÀH/C7ÀHb orylation and then unmasking of the C2 À H/C3 À H. [6] To the best of our knowledge,o ne example of directed iridium-catalysed C À Hb orylation [7] provides the only exception to these requirements (Scheme 1, middle left). [8] This process while notable uses ruthenium and iridium catalysts and substrates containing C6 substituents are not viable (6,7-disubstituted indoles are also bioactive motifs for example,i ndole isosteres of combrestatins). [5, 6c,9] Therefore as imple,p recious metal free route for the C À Hb orylation of indoles that is selective for:( i) C7 (over C2), including for C6 substituted indoles,a nd (ii)C5 (over C3), would be highly notable particularly if using areadily removed directing group.…”