A Probiotic Strain of Bacillus polyfermenticus Reduces DMH Induced Precancerous Lesions in F344 Male Rat

Park, Eunju; Jeon, Gyeong-Im; Park, Jun‐Seok; Paik, Hyun‐Dong

doi:10.1248/bpb.30.569

Cited by 51 publications

(16 citation statements)

References 37 publications

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“…From this report, the authors suggested that the adjuvant administration of probiotics along with chemotherapy can reduce the occurrence of chemotherapy induced diarrhea. Several studies have shown that either live vegetative cells or endospores of some Bacillus isolates can prevent colon carcinogenesis [45] or discharge antimicrobial substances against Gram-positive bacteria, such as Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile [46]. This again suggests that Bacillus spores based probiotics can also be a potential candidate to be used an effective probiotic for the chemotherapy induced diarrhea.…”

Section: Effect Of Probiotics In Certain Git Diseases Chemotherapy Inmentioning

confidence: 99%

Probiotics for Human and Poultry Use in the Control of Gastrointestinal Disease: A Review of Real-World Experiences

Téllez¹,

Rodríguez‐Fragoso²,

Va³

et al. 2013

Altern Integ Med

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Over a century ago Eli Metchnikoff proposed the revolutionary idea to consume viable bacteria to promote health by modulating the intestinal microflora. The idea is more applicable now than ever, since bacterial antimicrobial resistance has become a serious worldwide problem both in medical and agricultural fields. The interest in digestive physiology and the microbiome has generated data whereby well being of all living organisms with a digestive tract can be enhanced and the risk of disease reduced. Given the recent international legislation and domestic consumer pressures to withdraw growth-promoting antibiotics and limit antibiotics available for treatment of bacterial infections, probiotics can offer alternative options. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Current indications are that mechanism of action involves a number of possibilities like rapid activation of innate host immune responses, assisting in the digestion of food materials etc. In this review, we focused on applying probiotic concept to alleviate chronic constipation and idiopathic diarrhea in humans or for specific pathogen reduction and improvement of GIT diseases in poultry.

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Section: Effect Of Probiotics In Certain Git Diseases Chemotherapy Inmentioning

confidence: 99%

Probiotics for Human and Poultry Use in the Control of Gastrointestinal Disease: A Review of Real-World Experiences

Téllez¹,

Rodríguez‐Fragoso²,

Va³

et al. 2013

Altern Integ Med

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“…Consumption of probiotics as a dietary supplement has been reported to show some anticancer capacity (11,39). Most studies, however, have focused on the effects of probiotics to prevent the growth of cancerous cells.…”

Section: Downloaded By [University Of Saskatchewan Library] At 23:50 mentioning

confidence: 99%

ProbioticLactobacillus AcidophilusandL. CaseiMix Sensitize Colorectal Tumoral Cells to 5-Fluorouracil-Induced Apoptosis

Baldwin

Millette

Oth

et al. 2010

Nutrition and Cancer

143

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To assess the potential of Lactobacillus acidophilus and Lactobacillus casei strains to increase the apoptosis of a colorectal cancer cell line in the presence of 5-fluorouracil (5-FU), LS513 colorectal cancer cells were treated for 48 h with increasing concentrations of these lactic acid bacteria (LAB) in the presence of 100 mu g/ml of 5-FU. In the presence of 10(8) CFU/ml of live LAB, the apoptotic efficacy of the 5-FU increased by 40%, and the phenomenon was dose dependent. Moreover, irradiation-inactivated LAB caused the same level of induction, whereas microwave-inactivated LAB reduced the apoptotic capacity of the 5-FU. When cells were treated with a combination of live LAB and 5-FU, a faster activation of caspase-3 protein was observed, and the p21 protein seems to be downregulated. These results suggest that live L. acidophilus and L. casei are able to increase the apoptosis-induction capacity of 5-FU. The mechanisms of action are still not elucidated, and more research is needed to understand them. This is the first set of experiments demonstrating that some strains of LAB can enhance the apoptosis-induction capacity of the 5-FU. Based on these results, it is possible to speculate that LAB or probiotics could be used as an adjuvant treatment during anticancer chemotherapy.

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“…to humans stimulates IgG production and modulates the number of CD4 ϩ , CD8 ϩ , or natural killer cells (35). Anticancer effect of this bacterium was also reported in studies using a dimethylhydrazine-induced colon cancer model in rats (41,47). However, the effect of B.P.…”

mentioning

confidence: 81%

The angiogenic effect of probioticBacillus polyfermenticuson human intestinal microvascular endothelial cells is mediated by IL-8

Choi

Kim

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Angiogenesis is required for wound healing and repair, but dysregulated angiogenesis is involved in gastrointestinal inflammation. Bacillus polyfermenticus (B.P.) is a probiotic bacterium clinically used for a variety of intestinal disorders in East Asia. Here we investigated the effect of B.P. on angiogenesis of human intestinal microvascular endothelial cells (HIMECs) and wound healing in intestinal mucosa. Exposure of HIMECs to the conditioned medium of B.P. cultures (B.P. CM) increased cell migration, permeability, and tube formation. Production of the proangiogenic cytokine IL-8 was increased by B.P. CM, and neutralizing antibodies against IL-8 or IL-8 receptor CXCR2 reduced tube formation as well as actin stress fiber formation. B.P. CM also increased NF-kappaB activation, and inhibitors of NF-kappaB suppressed B.P. CM-induced tube formation and IL-8 production. Furthermore, B.P. facilitated recovery of mice from colitis as shown by increased body weight and reduced rectal bleeding and histological severity. B.P. also increased angiogenesis and mouse IL-8 production in the mucosal layer. Collectively, these results show that B.P. increases angiogenesis of HIMECs in a NF-kappaB/IL-8/CXCR2-dependent manner. Moreover, B.P. promotes angiogenesis in the mucosa during recovery of mice from colitis, suggesting that this probiotic may be clinically used to facilitate intestinal wound healing.

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A Probiotic Strain of Bacillus polyfermenticus Reduces DMH Induced Precancerous Lesions in F344 Male Rat

Cited by 51 publications

References 37 publications

Probiotics for Human and Poultry Use in the Control of Gastrointestinal Disease: A Review of Real-World Experiences

Probiotics for Human and Poultry Use in the Control of Gastrointestinal Disease: A Review of Real-World Experiences

ProbioticLactobacillus AcidophilusandL. CaseiMix Sensitize Colorectal Tumoral Cells to 5-Fluorouracil-Induced Apoptosis

The angiogenic effect of probioticBacillus polyfermenticuson human intestinal microvascular endothelial cells is mediated by IL-8

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