A probiotic combination attenuates experimental colitis through inhibition of innate cytokine production

Kim, M.S.; Byun, Jun Soo; Yoon, Yeo-Sang; Yum, Do-Young; Chung, Myung Jun; Lee, J.C.

doi:10.3920/bm2016.0031

Cited by 20 publications

(11 citation statements)

References 54 publications

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“…Lactobacillus acidophilus and Bifidobacterium were the main probiotic in intestine, which play crucial roles in the maintenance of gastrointestinal micro-ecological balance 39 . APP/PS1 mice showed less quantities of these two beneficial microbes compared to C57BL/6 mice, while JATH treatment elevated their amount (Fig.…”

Section: Resultsmentioning

confidence: 99%

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

Wang

Jiang

Ouyang

et al. 2019

Sci Rep

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Alzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those major pathological symptoms. Jatrorrhizine (JAT), a main component of a traditional Chinese herbal, coptidis rhizome, has been shown to have neuroprotective effects and we previously showed that it is also able to clear oxygen free radicals and reduce inflammatory responses. In this study, we demonstrated that JAT administration could alleviate the learning and memory deficits in AD. Furthermore, we also found that JAT treatment reduced the levels of Aβ plaques in the cortex and hippocampus of APP/PS1 double-transgenic mice. Other studies suggest that there are gut microbiome alterations in AD. In order to explore the underlying mechanisms between gut microbiota and AD, DNA sequencing for 16s rDNA V3-V4 was performed in fecal samples from APP/PS1 transgenic mice and C57BL/6 wild-type (WT) mice. Our results indicated that APP/PS1 mice showed less Operational Taxonomic Units (OTUs) abundance in gut microbiota than WT mice and with different composition. Furthermore, JAT treatment enriched OTUs abundance and alpha diversity in APP/PS1 mice compared to WT mice. High dose of JAT treatment altered the abundance of some specific gut microbiota such as the most predominant phylum Firmicutes and Bacteroidetes in APP/PS1 mice. In conclusion, APP/PS1 mice display gut dysbiosis, and JAT treatment not only improved the memory deficits, but also regulated the abundance of the microbiota. This may provide a therapeutic way to balance the gut dysbiosis in AD patients.

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Section: Resultsmentioning

confidence: 99%

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

Wang

Jiang

Ouyang

et al. 2019

Sci Rep

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“…Lactobacillus casei and Bifidobacterium lactis ameliorated injury to the intestinal mucosa and liver in a 2,4,6-trinitrobenzene sulfonic acid-induced colitis model [ 38 ]. Also, treatment with a probiotic combination that included lactobacilli, bifidobacteria, and streptococci reduced the levels of proinflammatory cytokines in colitis [ 39 ]. In this study, we evaluated the efficacy of a combination of 12 probiotics (lactobacilli, bifidobacteria, and streptococci) with prebiotics, rosavin, and zinc for the treatment of IBD.…”

Section: Discussionmentioning

confidence: 99%

A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model

et al. 2018

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BackgroundAn altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated the therapeutic effect of 12 probiotics in combination with prebiotics, rosavin, and zinc in the dextran sodium sulfate (DSS)-induced colitis mouse model.MethodsThe probiotic complex or the combination drug was administered orally to mice with DSS-induced colitis, and the body weight, disease activity index, colon length, and histopathological parameters were evaluated. Also, the combination drug was applied to HT-29 epithelial cells, and the expression of monocyte chemoattractant protein 1 (MCP-1) was evaluated by real-time polymerase chain reaction.ResultsAdministration of the combination drug attenuated the severity of DSS-induced colitis. Moreover, the combination drug significantly reduced the levels of the proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, IL-1β, and IL-17, and significantly increased the levels of Foxp3 and IL-10 in colon sections. Additionally, treatment with the combination drug reduced MCP-1 expression in HT-29 cells. Treatment with the combination drug decreased the levels of α-smooth muscle actin and type I collagen compared with vehicle treatment in mice with DSS-induced colitis.ConclusionThese results suggest that the combination of a probiotic complex with rosavin, zinc, and prebiotics exerts a therapeutic effect on IBD by modulating production of pro- and anti-inflammatory cytokines and the development of fibrosis.

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“…Recently, a large number of antibiotic-resistant bacteria have been found in dairy products, for example, Salmonella enterica in dry milk nutrition, Staphylococcus aureus in raw and pasteurized milk and in ice cream and vancomycin-resistant Enterococcus faecium in cheeses [15,31]. There is information in the literature that some bacteriocins produced by lactic acid bacteria can inhibit foodborne multidrug-resistant pathogens, which favorably distinguishes them from other registered bacteriocins with a rather narrow inhibitory spectrum [24,26].…”

Section: Bacteriocins Of Lactobacillus Isolated From Foodmentioning

confidence: 99%

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2021

Biopolym. Cell

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The review presents the characteristics of bacteria of the Lactobacillus family and their abi lity to synthesize various bacteriocins. The classification of bacteriocins of lactobacilli is given, which includes three classes: class I -lantibiotics (peptides with a molecular weight of less than 5 kDa, which contain lanthionine), class II -unmodified bacteriocins, also called nonlantibiotics (heat-resistant peptides , which do not contain lanthionine and have a molecular weight less than 10 kDa), and class III -a poorly studied group of thermolabile proteins with a molecular weight of more than 30 kDa. Lactobacilli are shown to synthesize a wide spectrum of bacteriocins, which demonstrate a variety of actions and are able to inhibit the growth of numerous species of opportunistic gram-positive microflora. The article also provides the examples of bacteriocins produced by Lactobacillus isolated from food products (fermented meat, fish, kombucha, goat milk, koumiss, etc.) and various human biotopes (microbiota of breast milk, intestinal tract and vaginal secretions). Additionally, the review shows the prospects of wide application of bacteriocins synthesized by Lactobacillus in the food and pharmaceutical industries.

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A probiotic combination attenuates experimental colitis through inhibition of innate cytokine production

Cited by 20 publications

References 54 publications

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model

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