A probabilistic map of negative motor areas of the upper limb and face: a brain stimulation study

Rech, Fabien; Herbet, Guillaume; Gaudeau, Yann; Mézières, Sophie Wantz; Moureau, Jean-Marie; Moritz‐Gasser, Sylvie; Duffau, Hugues

doi:10.1093/brain/awz021

Cited by 77 publications

(70 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, the significant association between BP and ECS‐based NPMA was much higher in NPMA‐related gyri than NPMA‐unrelated gyri. Furthermore, the locations of NPMA‐related gyri were consistent with previous studies . These results indicated that non–task‐specific BPs need to be located in NPMA‐related gyri to represent the crucial role of the NPMA.…”

Section: Discussionsupporting

confidence: 90%

A score to map the lateral nonprimary motor area: Multispectrum intrinsic brain activity versus cortical stimulation

et al. 2019

View full text Add to dashboard Cite

Objective: Multispectrum electrocorticographic components are critical for mapping the nonprimary motor area (NPMA). The objective of this study was to derive and validate a reliable scoring system for electrocorticography-based NPMA mapping (NPMA score) to replace electrical cortical stimulation (ECS) during brain surgery. Methods: We analyzed 14 consecutive epilepsy patients with subdural electrodes implanted in the frontal lobe at Kyoto University Hospital. The NPMA score was retrospectively derived from multivariate analysis in the derivation group (patients = 7, electrodes = 713, during 2010-2013) and validated in the validation group (patients = 7, electrodes = 772, during 2014-2017). We assessed the accuracy and reliability of the score relative to ECS in determining the NPMA and predicting postoperative functional outcomes. Results: Multivariate analysis in the derivation group led to an 8-point score for predicting ECS-based NPMA (1 point for anatomical localization of the electrode and 1 or 2 points for movement-related electrocorticographic components regardless of somatotopy in very slow cortical potential shifts [<0.5 Hz], 40-80-Hz band power increase, and 8-24-Hz band power decrease), which was validated in the validation group. The area under the receiver operating characteristic curve (AUC) was 0.89 in the derivation group. Good prediction (specificity = 94%, sensitivity = 100%)and discrimination (AUC = 0.87) were reproduced in the validation group. Overall, higher NPMA scores identified 2 patients with postoperative deficits after frontal lobe resection. Significance: The NPMA score is reliable for NPMA mapping, potentially replacing ECS. It is a potential prognostic marker for postoperative functional deficits. K E Y W O R D Selectrical cortical stimulation, event-related synchronization, movement-related cortical potential, premotor area, supplementary motor area

show abstract

Section: Discussionsupporting

confidence: 90%

A score to map the lateral nonprimary motor area: Multispectrum intrinsic brain activity versus cortical stimulation

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In this connectome-based surgical resection, the needs of the patient and his/her family should be accurately defined before surgery, based on his/her lifestyle (job, leisure, or hobbies) and environment, in order to select the optimal tasks enabling a reliable intraoperative DEM and cognitive monitoring in awake patients [ 22 , 23 ]. Tasks should be adapted to the proximity of the cortical epicenters (e.g., complex bimanual movement close to the perirolandic cortex if the patient wants to preserve a high degree of dexterity [ 24 ]; or semantics near the dorsolateral prefrontal cortex to preserve higher-order cognitive functions [ 25 ]) and to the proximity of the WM tracts underpinning the functional systems [ 13 , 26 ]. For example, verbal and non-verbal semantic processes must be mapped regardless of the tumor location, since the inferior fronto-occipital fasciculus should represent the deep functional limit of the resection in all cases, due to its critical role in noetic consciousness and metacognition (knowing of knowing) [ 27 , 28 ].…”

Section: The Concept Of Neuroplasticity In a Meta-networking Framementioning

confidence: 99%

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Duffau

2020

Cancers

Self Cite

View full text Add to dashboard Cite

Intraoperative direct electrostimulation mapping (DEM) is currently the gold-standard for glioma surgery, since functional-based resection allows an optimization of the onco-functional balance (increased resection with preserved quality of life). Besides intrasurgical awake mapping of conation, cognition, and behavior, preoperative mapping by means of functional neuroimaging (FNI) and transcranial magnetic stimulation (TMS) has increasingly been utilized for surgical selection and planning. However, because these techniques suffer from several limitations, particularly for direct functional mapping of subcortical white matter pathways, DEM remains crucial to map neural connectivity. On the other hand, non-invasive FNI and TMS can be repeated before and after surgical resection(s), enabling longitudinal investigation of brain reorganization, especially in slow-growing tumors like low-grade gliomas. Indeed, these neoplasms generate neuroplastic phenomena in patients with usually no or only slight neurological deficits at diagnosis, despite gliomas involving the so-called “eloquent” structures. Here, data gained from perioperative FNI/TMS mapping methods are reviewed, in order to decipher mechanisms underpinning functional cerebral reshaping induced by the tumor and its possible relapse, (re)operation(s), and postoperative rehabilitation. Heterogeneous spatiotemporal patterns of rearrangement across patients and in a single patient over time have been evidenced, with structural changes as well as modifications of intra-hemispheric (in the ipsi-lesional and/or contra-lesional hemisphere) and inter-hemispheric functional connectivity. Such various fingerprints of neural reconfiguration were correlated to different levels of cognitive compensation. Serial multimodal studies exploring neuroplasticity might lead to new management strategies based upon multistage therapeutic approaches adapted to the individual profile of functional reallocation.

show abstract

“…The motor effect of both PMC and S1 stimulations resemble the negative motor responses, described by Luders et al 19 as the cessation/arrest or decrease of the ongoing voluntary movement. It has been shown that negative motor responses can occur for both upper limb and speech-related movements 20 and that negative motor responses within BA6 can arrest both movements simultaneously 21 . Although the latter case was also observed in the present study (4 out of 17 trials), in most PMC stimulations (as well as in S1 stimulations), DES selectively blocked hand movements without affecting speech-related movements during the on-line motor monitoring task.…”

Section: Discussionmentioning

confidence: 99%

“…However, caution is needed in directly comparing previous studies with the present one, due to anatomical differences in stimulation sites over PMC 20,31 . In the present study, effective sites are located mainly in an area compatible with the potential homolog of the rostral sector of the non-human primate ventral PMC (F5) 34,35 .…”

Section: Cs Precsmentioning

confidence: 94%

Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions

et al. 2020

View full text Add to dashboard Cite

A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored their real-time performance, while different brain areas were transiently impaired by direct electrical stimulation (DES). In a second experiment, awake patients retrospectively reported their motor performance after DES. Based on anatomo-clinical evidence from motor awareness disorders following brain damage, the premotor cortex (PMC) was selected as a target area and the primary somatosensory cortex (S1) as a control area. In both experiments, DES on both PMC and S1 interrupted movement execution, but only DES on PMC dramatically altered the patients' motor awareness, making them unconscious of the motor arrest. These findings endorse PMC as a crucial hub in the anatomo-functional network of human motor awareness.

show abstract

A probabilistic map of negative motor areas of the upper limb and face: a brain stimulation study

Cited by 77 publications

References 46 publications

A score to map the lateral nonprimary motor area: Multispectrum intrinsic brain activity versus cortical stimulation

A score to map the lateral nonprimary motor area: Multispectrum intrinsic brain activity versus cortical stimulation

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions

Contact Info

Product

Resources

About