A Printed Organic Circuit System for Wearable Amperometric Electrochemical Sensors

Shiwaku, Rei; Matsui, Hiroyuki; Nagamine, Kuniaki; Uematsu, Masashi; Mano, Taisei; Maruyama, Yuki; Nomura, Ayako; Tsuchiya, Kensuke; Hayasaka, Kazuma; Takeda, Yasunori; Fukuda, Takashi; Kumaki, Daisuke; Tokito, Shizuo

doi:10.1038/s41598-018-24744-x

Cited by 51 publications

(54 citation statements)

References 27 publications

(31 reference statements)

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“…The other solution involves devices that do not require silicon or any kind of discrete components at all [65]. This second approach may have been completely unfeasible only a few years ago, but progress in printed electronics may soon enough make it possible [66][67][68].…”

Section: Design and Fabrication Of Wearable Devicesmentioning

confidence: 99%

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

et al. 2019

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Smart wearables, among immediate future IoT devices, are creating a huge and fast growing market that will encompass all of the next decade by merging the user with the Cloud in a easy and natural way. Biological fluids, such as sweat, tears, saliva and urine offer the possibility to access molecular-level dynamics of the body in a non-invasive way and in real time, disclosing a wide range of applications: from sports tracking to military enhancement, from healthcare to safety at work, from body hacking to augmented social interactions. The term Internet of Wearables (IoW) is coined here to describe IoT devices composed by flexible smart transducers conformed around the human body and able to communicate wirelessly. In addition the biochemical transducer, an IoW-ready sensor must include a paired electronic interface, which should implement specific stimulation/acquisition cycles while being extremely compact and drain power in the microwatts range. Development of an effective readout interface is a key element for the success of an IoW device and application. This review focuses on the latest efforts in the field of Complementary Metal–Oxide–Semiconductor (CMOS) interfaces for electrochemical sensors, and analyses them under the light of the challenges of the IoW: cost, portability, integrability and connectivity.

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Section: Design and Fabrication Of Wearable Devicesmentioning

confidence: 99%

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

et al. 2019

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“…An OFET device, shown in Figure 1A, was fabricated as described in previous papers [23]. A silver electrode, acting as a gate electrode, was attached by printing with an inkjet printer (Dimatix DMP2381, Fujifilm Co., Tokyo, Japan) to a glass plate coated with cross-linked PVP for surface treatment, followed by heating at 120 • C to sinter the silver nanoparticles.…”

Section: Fabrication Of An Ofet Devicementioning

confidence: 99%

“…In order to perform the measurement with an actual sample at home, it is necessary to improve the signal/noise ratio by one digit or more. We should consider combinations with noise reduction circuits [23] and/or efforts to increase the number of scans to obtain ∆V g values, in order to reduce the influence of random fluctuation.…”

Section: Relationship Between Saccharide Concentration and Curve Shiftmentioning

confidence: 99%

Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor

et al. 2018

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Sensor devices that can be fabricated on a flexible plastic film produced at a low cost using inkjet-printing technology are suitable for point-of-care applications. An organic field-effect transistor (OFET)-based biosensor can function as a potentiometric electrochemical sensor. To investigate the usefulness of an OFET-based biosensor, we demonstrated the detection of 1,5-anhydroglucitol (1,5-AG) and glucose, which are monosaccharides used as biomarkers of diabetes. An OFET-based biosensor combined with a Prussian blue (PB) electrode, modified with glucose oxidase (GOx) or pyranose oxidase (POx), was utilized for the detection of the monosaccharides. When the GOx- or POx-PB electrode was immersed in glucose solution at the determined concentration, shifts in the low-voltage direction of transfer characteristic curves of the OFET were observed to be dependent on the glucose concentrations in the range of 0–10 mM. For 1,5-AG, the curve shifts were observed only with the POx-PB electrode. Detection of glucose and 1,5-AG was achieved in a substrate-specific manner of the enzymes on the printed OFET-biosensor. Although further improvements are required in the detection concentration range, the plastic-filmOFET-biosensors will enable the measurement of not only diabetes biomarkers but also various other biomarkers.

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“…(20,21) The printing technology has emerged as a low-cost, environment-friendly mass manufacturing technology for the fabrication of next-generation printed wearable flexible devices based on thin-film transistors. (22)(23)(24)(25)(26)(27) In the present study, we developed a unique organic inverter-circuit-based enzyme biosensor with tunable limit detection. The biosensing cell was composed of a carbon-based extendedgate electrode that is modified by an enzyme and the reference electrode was connected to the input line of the inverter circuit, and the output line of the circuit was connected to a simple electrophoretic display that shows a distinct color change.…”

Section: Introductionmentioning

confidence: 99%

An L-lactate Biosensor Based on Printed Organic Inverter Circuitry and with a Tunable Detection Limit

Nagamine¹,

Mano²,

Shiwaku³

et al. 2019

Sensors and Materials

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In this study, we showed proof-of-principle experiments to demonstrate a printed organic inverter-circuit-based enzyme sensor with an extended-gate electrode with a lactate oxidase (LOx) and Prussian Blue carbon-graphite ink active area for the first time to inform users of an L-lactate overlimit concentration via a simple integrated electrophoretic display. The twostage organic inverter circuit exhibited an abrupt shift in output voltage depending on the potentiometric sensor signal imposed on the constant input voltage of the inverter circuit, resulting in a distinct color change of the display connected to the output line of the inverter circuit. The L-lactate concentration limit was tuned by changing the input voltage of the inverter circuit. This new type of wearable biosensor, notifying the user of an overlimit condition, can arbitrarily be tuned by professionals such as medical doctors or sports trainers and would be helpful for users who do not have sufficient knowledge about the detected biomarkers.

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A Printed Organic Circuit System for Wearable Amperometric Electrochemical Sensors

Cited by 51 publications

References 27 publications

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

CMOS Interfaces for Internet-of-Wearables Electrochemical Sensors: Trends and Challenges

Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor

An L-lactate Biosensor Based on Printed Organic Inverter Circuitry and with a Tunable Detection Limit

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