A primary SERS-active interconnected Si-nanocore network for biomolecule detection with plasmonic nanosatellites as a secondary boosting mechanism

Powell, Jeffery Alexander; Venkatakrishnan, Krishnan; Tan, Bo

doi:10.1039/c7ra01970j

Cited by 4 publications

(3 citation statements)

References 57 publications

(45 reference statements)

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“…The test is performed by collecting the saliva sample to place 10 µL of the sample mixed with buffer onto the nanostructured sensor for label-free SERS detection. The nanostructured sensor was fabricated using the physical synthesis process of multiphoton ionization using an ultrashort pulsed laser [ 21 ]. The physical characterization of nanostructured sensors showed that the sensors are <10 nm, which has substantially improved the sensor’s SERS sensitivity [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The ions in the plasma plume primarily comprise Si ions (evaporated from the Si) and Oxygen ions from the surrounding atmospheric air. The interaction of ionic species in the plume leads to nanoparticle cluster formation, which condenses on the surface of the silicon substrate [ 21 ]. These nanoparticle clusters are arranged three-dimensionally on the surface of Silicon.…”

Section: Methodsmentioning

confidence: 99%

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Label-Free Saliva Test for Rapid Detection of Coronavirus Using Nanosensor-Enabled SERS

et al. 2023

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The recent COVID-19 pandemic has highlighted the inadequacies of existing diagnostic techniques and the need for rapid and accurate diagnostic systems. Although molecular tests such as RT-PCR are the gold standard, they cannot be employed as point-of-care testing systems. Hence, a rapid, noninvasive diagnostic technique such as Surface-enhanced Raman scattering (SERS) is a promising analytical technique for rapid molecular or viral diagnosis. Here, we have designed a SERS- based test to rapidly diagnose SARS-CoV-2 from saliva. Physical methods synthesized the nanostructured sensor. It significantly increased the detection specificity and sensitivity by ~ten copies/mL of viral RNA (~femtomolar concentration of nucleic acids). Our technique combines the multiplexing capability of SERS with the sensitivity of novel nanostructures to detect whole virus particles and infection-associated antibodies. We have demonstrated the feasibility of the test with saliva samples from individuals who tested positive for SARS-CoV-2 with a specificity of 95%. The SERS—based test provides a promising breakthrough in detecting potential mutations that may come up with time while also preparing the world to deal with other pandemics in the future with rapid response and very accurate results.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Label-Free Saliva Test for Rapid Detection of Coronavirus Using Nanosensor-Enabled SERS

et al. 2023

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“…With the fast development of nanotechnique, although the shape of the nanostructure is abundant (nanoplates, nanorods, nanoflowers, nanosatellites, etc.) and can be precisely controlled [25][26][27][28], nanosphere is the most easily synthesized and also the most stabilized structure. Seen from the point of ease and convenience, silver nanosphere structure (figure 1a) synthesized by citrate-reduced method was chosen as the SERS substrate here [23,29].…”

Section: Resultsmentioning

confidence: 99%

Rapid and sensitive detection of uranyl ion with citrate-stabilized silver nanoparticles by the surface-enhanced Raman scattering technique

et al. 2018

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Uranium contamination poses a huge threat to human health due to its widespread use in the nuclear industry and weapons. We proposed a simple and convenient wet-state SERS method for uranyl detection based on the citrate-stabilized silver nanoparticles. The effect of citrate on the detection performance was also discussed. By using the citrate as an internal reference to normalize the peak of uranyl, a quantitative analysis was achieved and a good linear relationship of uranyl concentration from 0.2 to 5 µM with the limit of detection of 60 nM was obtained. With its simplicity, convenience and cost-effectiveness, this method has great potential for the detection of other molecules also.

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Nano structured sensing surface: Significance in sensor fabrication

Paladiya

Kiani

2018

Sensors and Actuators B: Chemical

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A primary SERS-active interconnected Si-nanocore network for biomolecule detection with plasmonic nanosatellites as a secondary boosting mechanism

Abstract: We report in this study, the development of a polymorphic biosensitive Si nanocore superstructure as a SERS biosensing platform.

Cited by 4 publications

References 57 publications

Label-Free Saliva Test for Rapid Detection of Coronavirus Using Nanosensor-Enabled SERS

Label-Free Saliva Test for Rapid Detection of Coronavirus Using Nanosensor-Enabled SERS

Rapid and sensitive detection of uranyl ion with citrate-stabilized silver nanoparticles by the surface-enhanced Raman scattering technique

Nano structured sensing surface: Significance in sensor fabrication

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