A primary health care curriculum in action: The lived experience of primary health care nurses in a school of nursing in the Philippines: A phenomenological study

Arthur, David; Drury, John; Sy-Sinda, Maria Teresita; Nakao, Ramonita; Lopez, A; Gloria, Grace; Turtal, Rowena; Luna, Evelyn

doi:10.1016/j.ijnurstu.2005.03.007

Cited by 5 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SB225002 was procured from Tocris Bioscience (Bristol, UK). Drug preparations for sorafenib and SB225002 were performed according to methods described elsewhere [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer

2015

View full text Add to dashboard Cite

Antiangiogenic therapy is important for the treatment of gynecological cancer. However, the therapeutic benefit derived from these treatments is transient, predominantly due to the selective activation of compensatory proangiogenic pathways that lead to rapid development of resistance. We aimed to identify and target potential alternative signaling to anti-vascular endothelial growth factor (VEGF) therapy, with a view toward developing a combination of antiangiogenic agents to provide extended therapeutic benefits. We developed a preclinical in vivo phenotypic resistance model of ovarian cancer resistant to antiangiogenic therapy. We measured dynamic changes in secreted chemokines and angiogenic signaling in tumors and plasma in response to anti-VEGF treatment, as tumors advanced from the initial responsive phase to progressive disease. In tumors that progressed following sorafenib treatment, gene and protein expression levels of proangiogenic CXC chemokines and their receptors were significantly elevated, compared with responsive tumors. The chemokine (C-X-C motif) ligand 8 (CXCL8), also known as interleukin-8 (IL-8) increase was time-dependent and coincided with the dynamics of tumor progression. We used SB225002, a pharmacological inhibitor of chemokine (C-X-C motif) receptor 2 (CXCR2), to disrupt the CXC chemokine-mediated functions of ovarian cancer cells in in vitro assays of cell growth inhibition, spheroid formation, and cell migration. The combination of CXCR2 inhibitor with sorafenib led to a synergistic inhibition of cell growth in vitro, and further stabilized tumor progression following sorafenib in vivo. Our results suggest that CXCR2-mediated chemokines may represent an important compensatory pathway that promotes resistance to antiangiogenic therapy in ovarian cancer. Thus, simultaneous blockage of this proangiogenic cytokine pathway using CXCR2 inhibitors and the VEGF receptor (VEGFR) pathway could improve the outcomes of antiangiogenic therapy.

show abstract

“…SB225002 was procured from Tocris Bioscience (Bristol, UK). Drug preparations for sorafenib and SB225002 were performed according to methods described elsewhere [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer

2015

View full text Add to dashboard Cite

show abstract

“…The description of the phenomenological approach varied from a detailed description of the ontological and epistemological point of departure and how methodological considerations were implemented in the particular study (Friberg, Andersson, & Bengtsson, 2007) to brief or almost no descriptions of these aspects. The authors of 12 of the 37 articles described their research approach as descriptive phenomenology (Arthur et al, 2006;Esbensen, Swane, Hallberg, & Thome, 2008;O'Leary & Thorwick, 2006;Waite, 2006). Sixteen articles had an explicitly stated philosophical grounding-14 with reference to Husserl and/ or Merleau-Ponty, and two with reference to Heidegger.…”

Section: Phenomenological Approach and Methodological Abstractmentioning

confidence: 99%

“…The most frequently listed keywords, and those seen by the authors as central concepts in phenomenological philosophy, were experience or lived experience, bracketing, essence, and phenomenon (Esbensen et al, 2008;Kvåle, 2007;O'Leary & Thorwick, 2006). In eight articles, however, lived experience was the only mentioned keyword with explicit reference to phenomenology (Arthur et al, 2006;Joolaee, Nikbakht-Nasrabadi, Parsa-Yekta, Tschudin, & Mansouri, 2006;Newton, 2007;Prouty, Ward-Smith, & Hutto, 2006).…”

Section: Phenomenological Approach and Methodological Abstractmentioning

confidence: 99%

“…However, most often just the term phenomenon was mentioned, and not the investigated phenomenon (Kvåle, 2007;McKeown, 2007;Morgan, 2006;Ruth-Sahd & Tisdell, 2007). In several studies the term phenomenon was not mentioned at all (Arthur et al, 2006;Bent & Magilvy, 2006;Chou, Chen, Kuo, & Tzeng, 2006;O'Leary & Thorwick, 2006), whereas one author described the term as "the building blocks of human science and the basis for all knowledge" (Newton, 2007, p. 38).…”

Section: Phenomenological Approach and Methodological Abstractmentioning

confidence: 99%

See 1 more Smart Citation

What Makes a Phenomenological Study Phenomenological? An Analysis of Peer-Reviewed Empirical Nursing Studies

2010

View full text Add to dashboard Cite

This article contributes to the debate about phenomenology as a research approach in nursing by providing a systematic review of what nurse researchers hold as phenomenology in published empirical studies. Based on the assumption that presentations of phenomenological approaches in peer-reviewed journals have consequences for the quality of future research, the aim was to analyze articles presenting phenomenological studies and, in light of the findings, raise a discussion about addressing scientific criteria. The analysis revealed considerable variations, ranging from brief to detailed descriptions of the stated phenomenological approach, and from inconsistencies to methodological clarity and rigor. Variations, apparent inconsistencies, and omissions made it unclear what makes a phenomenological study phenomenological. There is a need for clarifying how the principles of the phenomenological philosophy are implemented in a particular study before publishing. This should include an articulation of methodological keywords of the investigated phenomenon, and how an open attitude was adopted.

show abstract

“…Data analysis followed Colaizzi's (1978) approach to analysis. [33][34][35][36][37] The analysis of the transcripts was initiated as soon as the transcript of each interview was completed, toward the aim of incorporating insights from earlier interviews into the ongoing data collection. The principal investigator read all the transcripts at least twice and listened to the interviews twice to gain an understanding of the flow of the interviews and ensure that the depth and meaning of each interview was fully understood.…”

Section: Discussionmentioning

confidence: 99%

“She Is NOT a Genuine Client”: Exploring Health Practitioner’s Mistrust of Rape Survivors in Nairobi, Kenya

Munala

Welle

Hohenshell

et al. 2018

Int Q Community Health Educ

View full text Add to dashboard Cite

Sexual violence is one of the most common forms of violence against women in Kenya. Recognizing this, the Kenyan government introduced health care sector guidelines for survivors of sexual violence. This study explores the care of rape survivors from the perspective of health-care practitioners and identifies a number of recommendations for improving the quality of care. Qualitative interviews were conducted with 28 health practitioners from eight post-rape care facilities located in Nairobi, Kenya. Data were analyzed using the Colaizzi's 1978 analytical model. The study uncovered a troubling tendency of health practitioners questioning the authenticity of a woman's claim, deeming some not to be genuine rape survivors. Doubts about the veracity of the client's story led to additional emotional drain on health practitioners. This judgment negatively impacted the quality of care for rape survivors and in some cases, leading practitioners to deny services and exposing survivors to secondary victimization.

show abstract

A primary health care curriculum in action: The lived experience of primary health care nurses in a school of nursing in the Philippines: A phenomenological study

Cited by 5 publications

References 16 publications

CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer

CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer

What Makes a Phenomenological Study Phenomenological? An Analysis of Peer-Reviewed Empirical Nursing Studies

“She Is NOT a Genuine Client”: Exploring Health Practitioner’s Mistrust of Rape Survivors in Nairobi, Kenya

Contact Info

Product

Resources

About